HARMINE HYDROCHLORIDE
- CAS No.
- 343-27-1
- Chemical Name:
- HARMINE HYDROCHLORIDE
- Synonyms
- 5S)-4;4-[[(4R;HarMine.HC;HARMINE HCL;BANISTERIN HCL;HARMINE HYDROCHLORID;harminemonohydrochlo;HARMINE HYDROCHLORIDE;CATHARANTHIN TARTRATE;HarmineHydrochloride>
- CBNumber:
- CB4780696
- Molecular Formula:
- C13H13ClN2O
- Molecular Weight:
- 248.71
- MDL Number:
- MFCD00012641
- MOL File:
- 343-27-1.mol
- MSDS File:
- SDS
| Melting point | 265-270°C |
|---|---|
| storage temp. | 2-8°C |
| solubility | Soluble in Water (up to 25 mg/ml). |
| form | powder |
| color | off-white to pale green |
| Merck | 14,4616 |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in distilled water may be stored at -20° for up to 3 months. |
| LogP | 3.173 (est) |
| CAS DataBase Reference | 343-27-1(CAS DataBase Reference) |
| FDA UNII | T89I34ODAA |
| EPA Substance Registry System | Harmine hydrochloride (343-27-1) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302+H312+H332-H351 | |||||||||
| Precautionary statements | P201-P280-P301+P312-P302+P352+P312-P304+P340+P312-P308+P313 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 20/21/22-40 | |||||||||
| Safety Statements | 22-36 | |||||||||
| RIDADR | 1544 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | MG9450000 | |||||||||
| HazardClass | 6.1(b) | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29339900 | |||||||||
| NFPA 704 |
|
HARMINE HYDROCHLORIDE price More Price(23)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SMB00461 | Harmine hydrochloride ≥98% (HPLC) | 343-27-1 | 100mg | $85.7 | 2024-03-01 | Buy |
| TCI Chemical | H0002 | Harmine Hydrochloride >98.0%(HPLC)(T) | 343-27-1 | 100mg | $18 | 2024-03-01 | Buy |
| TCI Chemical | H0002 | Harmine Hydrochloride >98.0%(HPLC)(T) | 343-27-1 | 1g | $104 | 2024-03-01 | Buy |
| Chem-Impex | 21756 | Harmine hydrochloride ≥ 98% (HPLC) | 343-27-1 | 5G | $120 | 2021-12-16 | Buy |
| ChemScene | CS-0009747 | Harmine hydrochloride | 343-27-1 | 20mg | $180 | 2021-12-16 | Buy |
HARMINE HYDROCHLORIDE Chemical Properties,Uses,Production
Description
Harmine (343-27-1) is a selective competitive and reversible inhibitor of MAO-A (IC50?= 8 μM).1?Harmine is a potent and specific inhibitor of both the kinase activity and autophosphorylation of tyrosine during translation DYRK1A (IC50‘s: DYRKA1A = 33 nM; DYRKA1B = 166 nM; DYRK2 = 1.9 μM; DYRK4 = 80 μM).2,3?Inhibits self-renewal and promotes differentiation of glioblastoma stem-like cells (GSLC’s) possibly via inhibition of Akt phosphorylation.4?Harmine has also been shown to possess antimicrobial, antifungal, antiplasmodial, antitumor, antioxidant, antimutagenic and antigenotoxic properties.5?Inhibits osteoclast differentiation and bone resorption via downregulation of c-Fos and NFATc1 induced by RANKL.6
Chemical Properties
yellow to slightly green crystalline powder
Uses
Harmine Monohydrochloride is an anti-viral agents for the treatment of EV71 infection. It inhibits enterovirus 71 replication by targeting NF-κB pathway.
Purification Methods
The hydrate crystallises as fluorescent crystals from water. The anhydrous salt has m 319o. [Beilstein 23/12 V 237.]
References
1) Wouters (1998)?Structural Aspects of Monoamine Oxidase and its Reversible Inhibition?Current Medicinal Chemistry,?5?137 2) Seifert?et al. (2008)?DYRK1A phosphorylates caspase 9 at an inhibitory site and is potently inhibited in human cells by harmine; FEBS J.,?275?6268 3) Gockler?et al. (2009)?Harmine specifically inhibits protein kinase DYRK1A and interferes with neurite outgrowth; FEBS J.,?276?6324 4) Liu?et al. (2013)?Harmine hydrochloride inhibits Akt phosphorylation and depletes the pool of cancer stem-like cells of glioblastoma; J .Neurooncol.,?112?39 5) Patel?et al. (2012)?A review on medical importance, pharmacological activity and bioanalytical aspects of beta-carboline alkaloid ‘Harmine’; Asian Pac. J. Trop. Biomed.,?2?660 6) Yoneazwa?et al. (2011)?Harmine, a β-carboline alkaloid, inhibits osteoclast differentiation and bone resorption in vitro and in vivo; Eur. J. Pharmacol.,?650?511
HARMINE HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BINBO BIOLOGICAL CO.,LTD | +8618629063126 | info@binbobiological.com | China | 390 | 58 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3619 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29881 | 58 |
| Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 | scglp@glp-china.com | CHINA | 1824 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | sales@biopurify.com | China | 3772 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22963 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39894 | 58 |
| Shanghai Standard Technology Co., Ltd. | 18502101150 | ft-sales@nature-standard.com | CHINA | 1923 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49374 | 58 |
View Lastest Price from HARMINE HYDROCHLORIDE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-29 | HARMINE HYDROCHLORIDE
343-27-1
|
US $0.00 / KG | 1KG | >99% HPLC | 1000KG | Changsha Staherb Natural Ingredients Co., Ltd. | |
 |
2024-11-28 | Harmine Hydrochloride
343-27-1
|
US $0.00 / kg | 1kg | 99% | 1000 kg | BINBO BIOLOGICAL CO.,LTD | |
 |
2023-02-24 | Harmine Hydrochloride
343-27-1
|
US $0.00 / ASSAYS | 5ASSAYS | ≥98%(HPLC) | 10 g | Shanghai Standard Technology Co., Ltd. |
-
- HARMINE HYDROCHLORIDE
343-27-1
- US $0.00 / KG
- >99% HPLC
- Changsha Staherb Natural Ingredients Co., Ltd.
-
- Harmine Hydrochloride
343-27-1
- US $0.00 / kg
- 99%
- BINBO BIOLOGICAL CO.,LTD
-
- Harmine Hydrochloride
343-27-1
- US $0.00 / ASSAYS
- ≥98%(HPLC)
- Shanghai Standard Technology Co., Ltd.