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N1-Methyl-Pseudouridine-5'-Triphosphate

N1-Methyl-Pseudouridine-5'-Triphosphate Structure
N1-Methyl-Pseudouridine-5'-Triphosphate structure
CAS No.
1428903-59-6
Chemical Name:
N1-Methyl-Pseudouridine-5'-Triphosphate
Synonyms
abs60156;N1-Me-pUTP;Pseudo-UTP-Na3;N1 -Me-Pseudo UTP;N1-Methylpseudo-UTP;N1-Methy-Pseudo-UTP;Cytidine Impurity 9;N1-Me-pUTP Tris salt;N1-Me-pUTP Sodium Salt;N1-Me-pUTP sodium solution
CBNumber:
CB48099851
Molecular Formula:
C10H17N2O15P3
Molecular Weight:
498.17
MDL Number:
MOL File:
1428903-59-6.mol
Last updated:2024-11-19 20:33:22
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N1-Methyl-Pseudouridine-5'-Triphosphate Properties

Density 2.010±0.06 g/cm3(Predicted)
pka 0.97±0.50(Predicted)
InChIKey OLRONOIBERDKRE-CAYFCZNJNA-N
SMILES O[C@@H]1[C@@H]([C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]1C1=CN(C)C(=O)NC1=O)O |&1:1,2,3,19,r|
FDA UNII 5ENC36P33M

N1-Methyl-Pseudouridine-5'-Triphosphate Chemical Properties,Uses,Production

Color

N1-Methyl-Pseudouridine-5'-Triphosphate is a colorless to slightly yellow.

Form

N1-Methyl-Pseudouridine-5'-Triphosphate is a solution in water.

Description

N1-Methyl-Pseudouridine-5'-Triphosphate, also known as N1-Methylpseudouridine-5'-Triphosphate, N1meΨTP, m1ΨTP, or 1-Methyl-PseudoUridine Phosphoramidite, is a modified NTP for incorporation into messenger RNAs (mRNA) using T7 RNA Polymerase. Incorporation of N1-Methylpseudouridine can reduce the immunogenicity of the resulting mRNA. In addition, the free form of the compound is prone to instability; it is advisable to consider the stable salt form (N1-Methylpseudouridine-5′-triphosphate trisodium) that retains the same biological activity.

Uses

1-Methylpseudouridine-5'-triphosphate Sodium Salt is a salt analogue of 1-Methylpseudouridine-5'-triphosphate, which can be used to optimize the cardiac delivery of modified mRNA

Advantages

The substitution of U with N1-Methyl-Pseudouridine-5'-Triphosphate (m1Ψ) not only bypasses immune response induced cytotoxicity, but also substantially enhances the effectiveness of both types of switches. The m1Ψ substitution induced higher protein expression of mRNA than other modified bases, allowing clearer detection of signals and better fold-change between ON and OFF states of the switches. In addition, the m1Ψ substitution enhanced the sensitivity and performance of synthetic RNA circuit composed of both miRNA- and RBP-sensing switches[1].

References

[1] Callum J C Parr. “N 1-Methylpseudouridine substitution enhances the performance of synthetic mRNA switches in cells.” Nucleic Acids Research 48 6 (2020): e35.

N1-Methyl-Pseudouridine-5'-Triphosphate Preparation Products And Raw materials

Raw materials

Preparation Products

N1-Methyl-Pseudouridine-5'-Triphosphate Suppliers

Global( 59)Suppliers
Supplier Tel Email Country ProdList Advantage
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19553 58
Zhejiang Hengkang Pharmaceutical Co., Ltd.
+86-576-83372028 +86-18868723926 bd1@hengkangpharm.cn China 119 58
Hangzhou Meiya Pharmaceutical Co Ltd 		+86-021-33686691 +8618001850931 sales@meiyapharm.com China 58 58
SHANGHAI T&W PHARMACEUTICAL CO., LTD. 		+86-021-61551413 +8618813727289 contact@trustwe.com China 5738 58
Zhejiang Huida Biotech Co., LTD 		008613515763466 8615669048680 wendy@huidabiotech.com CHINA 87 58
Finetech Industry Limited 		+86-27-87465837 +8618971612321 info@finetechnology-ind.com China 9639 58
Wuhan Fortuna Chemical Co., Ltd 		+86-027-59207850 info@fortunachem.com China 5978 58
NewCan Biotech Limited 		+86-0571-86912261 +8613735419629 sales@newcanbio.com China 9980 58
Labnetwork lnc. 		+86-27-50766799 +8618062016861 contact@labnetwork.com China 19987 58
Henan Aochuang Chemical Co.,Ltd. 		+86-0371-63689365 +8618638391208 sales@aochuangchem.com China 9237 58
Supplier Advantage
BOC Sciences 		58
Zhejiang Hengkang Pharmaceutical Co., Ltd.
58
Hangzhou Meiya Pharmaceutical Co Ltd 		58
SHANGHAI T&W PHARMACEUTICAL CO., LTD. 		58
Zhejiang Huida Biotech Co., LTD 		58
Finetech Industry Limited 		58
Wuhan Fortuna Chemical Co., Ltd 		58
NewCan Biotech Limited 		58
Labnetwork lnc. 		58
Henan Aochuang Chemical Co.,Ltd. 		58

View Lastest Price from N1-Methyl-Pseudouridine-5'-Triphosphate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
N1-Methyl-Pseudouridine-5'-Triphosphate pictures 2024-11-22 N1-Methyl-Pseudouridine-5'-Triphosphate
1428903-59-6
 US $0.00 / KG 1KG 98.0% 1kg/month WUHAN FORTUNA CHEMICAL CO., LTD
N1-Methylpseudouridine-5′-triphosphate pictures 2024-11-19 N1-Methylpseudouridine-5′-triphosphate
1428903-59-6
 US $50.00-113.00 / mg 10g TargetMol Chemicals Inc.
N1-methyl-Pseudo-UTP pictures 2024-08-08 N1-methyl-Pseudo-UTP
US $0.00 / ml 100ml ≥99%(HPLC) 20000L Hefei Huana Biomedical Technology Co.,Ltd.
2,4(1H,3H)-Pyrimidinedione, 5-[5-O-[hydroxy[[hydroxy(phosphonooxy)phosphinyl]oxy]phosphinyl]-β-D-ribofuranosyl]-1-methyl- N1-Methylpseudo-UTP N1-Methylpseudouridine-5'-triphosphate N1-Methyl-Pseudouridine-5'-Triphosphate 100mM solution N1-Methy-Pseudo-UTP.3Na 100mM solution N1-Methyl Pseudouridine-5'-Triphosphate, Trisodium Salt abs60156 1-Methylpseudouridine-5'-Triphosphate Trisodium salt 1-Methylpseudouridine-5'-Triphosphate sodium salt N1-Me-pUTP N1-Me-Pseudo-UTP.3Na 100mM solution N1 -Me-Pseudo UTP N-Methyl pseudouridine Triphosphate, Trisodium Salt N1-methyl-pseudouridine 5'-triphosphate, trisodium salt 100mM aqueous solution N1-Methy-Pseudo-UTP N1-Me-pUTP sodium solution Cytidine Impurity 9 2,4(1H,3H)-Pyrimidinedione, 5-[5-O-[hydroxy[[hydroxy(phosphonooxy)phosphinyl]oxy]phosphinyl]-β-D-ribofuranosyl]-1-methyl- N1-Methyl-Pseudouridine TP N1-Me-pUTP Tris salt N1-Me-pUTP Sodium Salt N1-Me-pUTP 100mM Tris Solution N1-Me-pUTP 200mM Tris Solution, GMP grade N1-Me-pUTP 100mM Sodium Solution, GMP grade N1-Me-pUTP 100mM Sodium Solution 1-Methyl pseudouridine Triphosphate, Trisodium Salt Pseudo-UTP-Na3 N1-Me-Pseudo UTP Trisodium solution N1-Me-Pseudo-UTP, 100mM Solution 1-Methyl pseudouridine triphosphate N1-Methyl-Pseudouridine-5'-Triphosphate N1-Methylpseudouridine-5- triphosphate.sodilum salt solution ((2R,3S,4R,5S)-3,4-Dihydroxy-5-(1-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)tetrahydrofuran-2-yl)methyl tetrahydrogen triphosphate 1428903-59-6 Pharmaceutical Nucleotide Coronavirus