2-Propenoic acid, 2-methyl-, 2-(2-pyridinyldithio)ethyl ester

General Description

Pyridyl disulfide ethyl methacrylate is a methacylate-based monomer used in the synthesis of poly(pyridyl disulfide ethyl methacrylate) [p(PDSMA)] and other copolymers. p(PDSMA) contains a pendant, protected thiol that can be used for post-polymerization functionalization via thiol-disulfide exchange reactions. Additionally, reaction progress can be typically monitored by absorption spectroscopy as the spectroscopic signature of the released 2-pyridinethione (λ max = 375 nm) is distinctly different from the pyridyl disulfide functionality (λ max = 280 nm) in the polymer. Due to their versatility, these materials have been used in a wide variety of biomedical applications such as the synthesis of polymer-biomolecule conjugates and drug delivery applications.