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ChemicalBook >> CAS DataBase List >>3H-Pyrazolo[3,4-d]pyrimidin-3-one, 6-[(2',3'-dihydro-2'-methylspiro[cyclopropane-1,4'(1'H)-isoquinolin]-7'-yl)amino]-1,2-dihydro-1-[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]-2-(2-propen-1-yl)-

3H-Pyrazolo[3,4-d]pyrimidin-3-one, 6-[(2',3'-dihydro-2'-methylspiro[cyclopropane-1,4'(1'H)-isoquinolin]-7'-yl)amino]-1,2-dihydro-1-[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]-2-(2-propen-1-yl)-

3H-Pyrazolo[3,4-d]pyrimidin-3-one, 6-[(2',3'-dihydro-2'-methylspiro[cyclopropane-1,4'(1'H)-isoquinolin]-7'-yl)amino]-1,2-dihydro-1-[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]-2-(2-propen-1-yl)- Structure
3H-Pyrazolo[3,4-d]pyrimidin-3-one, 6-[(2',3'-dihydro-2'-methylspiro[cyclopropane-1,4'(1'H)-isoquinolin]-7'-yl)amino]-1,2-dihydro-1-[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]-2-(2-propen-1-yl)- structure
CAS No.
2272976-28-8
Chemical Name:
3H-Pyrazolo[3,4-d]pyrimidin-3-one, 6-[(2',3'-dihydro-2'-methylspiro[cyclopropane-1,4'(1'H)-isoquinolin]-7'-yl)amino]-1,2-dihydro-1-[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]-2-(2-propen-1-yl)-
Synonyms
JUN76288;WEE1-IN-3;WEE1-IN-3, 10 mM in DMSO;WEE1IN3,cycle,Inhibitor,inhibit,cell,Wee1,WEE-1-IN-3,WEE1 IN 3,Anticancer;3H-Pyrazolo[3,4-d]pyrimidin-3-one, 6-[(2',3'-dihydro-2'-methylspiro[cyclopropane-1,4'(1'H)-isoquinolin]-7'-yl)amino]-1,2-dihydro-1-[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]-2-(2-propen-1-yl)-
CBNumber:
CB48344500
Molecular Formula:
C28H31N7O2
Molecular Weight:
497.59
MDL Number:
MOL File:
2272976-28-8.mol
Last updated:2024-11-19 20:33:22
Request For Quotation

3H-Pyrazolo[3,4-d]pyrimidin-3-one, 6-[(2',3'-dihydro-2'-methylspiro[cyclopropane-1,4'(1'H)-isoquinolin]-7'-yl)amino]-1,2-dihydro-1-[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]-2-(2-propen-1-yl)- Properties

Boiling point 702.4±70.0 °C(Predicted)
Density 1.39±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : 250 mg/mL (502.42 mM; Need ultrasonic)
pka 13.26±0.29(Predicted)
form Solid
color White to off-white

3H-Pyrazolo[3,4-d]pyrimidin-3-one, 6-[(2',3'-dihydro-2'-methylspiro[cyclopropane-1,4'(1'H)-isoquinolin]-7'-yl)amino]-1,2-dihydro-1-[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]-2-(2-propen-1-yl)- price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0146345 WEE1-IN-3 98.03% 2272976-28-8 5mg $400 2021-12-16 Buy
ChemScene CS-0146345 WEE1-IN-3 98.03% 2272976-28-8 10mg $680 2021-12-16 Buy
ChemScene CS-0146345 WEE1-IN-3 98.03% 2272976-28-8 25mg $1350 2021-12-16 Buy
ChemScene CS-0146345 WEE1-IN-3 98.03% 2272976-28-8 50mg $2200 2021-12-16 Buy
ChemScene CS-0146345 WEE1-IN-3 98.03% 2272976-28-8 100mg $3400 2021-12-16 Buy
Product number Packaging Price Buy
CS-0146345 5mg $400 Buy
CS-0146345 10mg $680 Buy
CS-0146345 25mg $1350 Buy
CS-0146345 50mg $2200 Buy
CS-0146345 100mg $3400 Buy

3H-Pyrazolo[3,4-d]pyrimidin-3-one, 6-[(2',3'-dihydro-2'-methylspiro[cyclopropane-1,4'(1'H)-isoquinolin]-7'-yl)amino]-1,2-dihydro-1-[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]-2-(2-propen-1-yl)- Chemical Properties,Uses,Production

Biological Activity

WEE1-IN-3 is a potent Wee1 kinase inhibitor with an IC50 of <10 nM. WEE1-IN-3 has anticancer activities[1]. WEE1-IN-3 (example 1) inhibits cancer cell growth with IC50 values of 100-1000 nM and <100 nM for SW480 cells and H23 cells, respectively[1].WEE1 kinase plays a role in the G2-M cell-cycle checkpoint arrest for ?Να repair before mitotic entry. Normal cells repair damaged DNA during GI arrest. Cancer cells often have a deficient G i-S checkpoint and depend on a functional G2-M checkpoint for DNA repair. WEE1 is overexpressed in various cancer types[1].

References

[1]. Peter Qinhua HUANG, et al. 1, 2 - dihydro- 3h- pyrazolo [3, 4 - d] pyrimidin -3 - one analogs. WO2019028008A1.

3H-Pyrazolo[3,4-d]pyrimidin-3-one, 6-[(2',3'-dihydro-2'-methylspiro[cyclopropane-1,4'(1'H)-isoquinolin]-7'-yl)amino]-1,2-dihydro-1-[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]-2-(2-propen-1-yl)- Preparation Products And Raw materials

Raw materials

Preparation Products

3H-Pyrazolo[3,4-d]pyrimidin-3-one, 6-[(2',3'-dihydro-2'-methylspiro[cyclopropane-1,4'(1'H)-isoquinolin]-7'-yl)amino]-1,2-dihydro-1-[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]-2-(2-propen-1-yl)- Suppliers

Global( 14)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32965 60
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32161 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38631 58
DC Chemicals 021-58447131 13564518121 sales@dcchemicals.com China 9409 58
Beijing Biocreative Technology Co., Ltd. 15522676233 3007606172@qq.com China 1248 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24644 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11974 58
RD International Technology Co., Limited 18024082417 market@ubiochem.com China 9266 58
sangon@qq.com CHINA 47239 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
TargetMol Chemicals Inc. 		58
InvivoChem 		58
TargetMol Chemicals Inc. 		58
DC Chemicals 58
Beijing Biocreative Technology Co., Ltd. 58
TargetMol Chemicals Inc. 58
Shanghai Yifei Biotechnology Co. , Ltd. 58
RD International Technology Co., Limited 58
58

View Lastest Price from 3H-Pyrazolo[3,4-d]pyrimidin-3-one, 6-[(2',3'-dihydro-2'-methylspiro[cyclopropane-1,4'(1'H)-isoquinolin]-7'-yl)amino]-1,2-dihydro-1-[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]-2-(2-propen-1-yl)- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
WEE1-IN-3 pictures 2024-11-19 WEE1-IN-3
2272976-28-8
 US $64.00-251.00 / mg 98.33% 10g TargetMol Chemicals Inc.
  • WEE1-IN-3 pictures
  • WEE1-IN-3
    2272976-28-8
  • US $64.00-251.00 / mg
  • 98.33%
  • TargetMol Chemicals Inc.
JUN76288 WEE1-IN-3 3H-Pyrazolo[3,4-d]pyrimidin-3-one, 6-[(2',3'-dihydro-2'-methylspiro[cyclopropane-1,4'(1'H)-isoquinolin]-7'-yl)amino]-1,2-dihydro-1-[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]-2-(2-propen-1-yl)- WEE1IN3,cycle,Inhibitor,inhibit,cell,Wee1,WEE-1-IN-3,WEE1 IN 3,Anticancer WEE1-IN-3, 10 mM in DMSO 2272976-28-8