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Methicillin Sodium Salt

CAS No.
132-92-3
Chemical Name:
Methicillin Sodium Salt
Synonyms
meticillin sodium;Methicillin sodium;Sodium methicillin;Meticillin sodium salt;Methicillin sodium salt;METHICILLIN SODIUM USP/EP/BP;Methicillin Sodium Salt USP/EP/BP;Sodium (2,6-dimethoxyphenyl)penicillin;sodium 6-(2,6-dimethoxybenzamido)penicillanate;TIANFU-CHEM -sodium 6-(2,6-dimethoxybenzamido)penicillanate
CBNumber:
CB4874973
Molecular Formula:
C17H19N2NaO6S
Molecular Weight:
402.39733
MDL Number:
MFCD07787409
MOL File:
132-92-3.mol
Last updated:2024-11-19 23:02:33

Methicillin Sodium Salt Properties

Melting point 196-197℃
Boiling point 640℃
Flash point >110°(230°F)
storage temp. 2-8°C
solubility DMSO (Slightly), Methanol (Slightly), Water (Slightly)
form powder
color white to off-white
Water Solubility Slightly soluble in acetone. Soluble in ethanol or water
Sensitive Light Sensitive
FDA UNII NBQ410S76Y

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS07,GHS08
Signal word  Danger
Hazard statements  H315-H317-H319-H334-H335
Precautionary statements  P280-P302+P352-P305+P351+P338
Hazard Codes  Xn
Risk Statements  36/37/38-42/43
Safety Statements  26-36
WGK Germany  2
RTECS  XH8950000
Toxicity LD50 oral in mouse: > 4gm/kg
NFPA 704
0
2 0

Methicillin Sodium Salt price More Price(17)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 51454 Methicillin sodium salt ≥85% (HPLC) 132-92-3 50mg $90.5 2024-03-01 Buy
Alfa Aesar J66414 Methicillin sodium salt, 90+% 132-92-3 1g $435 2024-03-01 Buy
Alfa Aesar J67100 Methicillin sodium salt, 50 mg/ml in distilled water, sterile-filtered 132-92-3 5x1ml $821 2023-06-20 Buy
Cayman Chemical 21007 Methicillin (sodium salt) ≥90% 132-92-3 25mg $37 2024-03-01 Buy
Cayman Chemical 21007 Methicillin (sodium salt) ≥90% 132-92-3 50mg $65 2024-03-01 Buy
Product number Packaging Price Buy
51454 50mg $90.5 Buy
J66414 1g $435 Buy
J67100 5x1ml $821 Buy
21007 25mg $37 Buy
21007 50mg $65 Buy

Methicillin Sodium Salt Chemical Properties,Uses,Production

Description

Methicillin is a semisynthetic penicillin antibiotic that can inhibit bacterial cell wall synthesis. It can be used to study methicillin-resistance in S. aureus.

Uses

antibacterial

Uses

Semi-synthetic antibiotic related to Penicillin. Antimicrobial.

Uses

Targets primarily the cell wall of Gram-positive organisms especially Staphylococcus aureus. Methicillin is used to study bacterium susceptibility, and to inhibit cell-wall synthesis. PBP's are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Methicillin Sodium Salt is inactivated by gastric acid so it is given to cells by other means in which gastric acid is not present in vitro.

Definition

ChEBI: Methicillin sodium is an organic sodium salt. It contains a methicillin(1-).

brand name

Staphcillin (Apothecon).

Clinical Use

During 1960, methicillin sodium, 2,6-dimethoxyphenylpenicillinsodium (Staphcillin), the second penicillin produced asa result of the research that developed synthetic analogs, wasintroduced for medicinal use.
Methicillin sodium is particularly resistant to inactivationby the penicillinase found in staphylococci and somewhatmore resistant than penicillin G to penicillinase fromBacillus cereus.

in vitro

similar to other β-lactam antibiotics, meticillin acts via inhibiting the synthesis of bacterial cell walls. meticillin can block the cross-linkage between the linear peptidoglycan polymer chains by binding to and competitively inhibiting the transpeptidase enzyme or penicillin-binding proteins [1].

in vivo

in a previous animal study, the treatment with methicillin or gentamicin or both was started 3 days after infection to a experimental mouse model of foreign body infection. results found that the treatment showed a significant effect, demonstrated as reduction of bacteria on the foreign body, for all three regimens with a reduction of up to 2 log units, but there was no synergism. however, the actual efficacy of the treatment was poor, though the local methicillin concentrations was greater than the mic for at least 72 h [2].

References

[1] https://en. wikipedia.org/wiki/meticillin
[2] espersen f, frimodt-m ller n, corneliussen l, riber u, rosdahl vt, skinh j p. effect of treatment with methicillin and gentamicin in a new experimental mouse model of foreign body infection. antimicrob agents chemother. 1994 sep;38(9):2047-53.

Methicillin Sodium Salt Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 90)Suppliers
Supplier Tel Email Country ProdList Advantage
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21634 55
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32161 58
Career Henan Chemica Co
+86-0371-86658258 +8613203830695 laboratory@coreychem.com China 30239 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD
86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6312 58
ANHUI WITOP BIOTECH CO., LTD
+8615255079626 eric@witopchemical.com China 23541 58
Shaanxi Dideu Medichem Co. Ltd
+86-029-89586680 +86-18192503167 1026@dideu.com China 7724 58
Finetech Industry Limited
+86-27-87465837 +8618971612321 info@finetechnology-ind.com China 9639 58
Shanghai kingmorn biotechnology Co.,Ltd.
021-62200788 15000569291 2199306478@qq.com CHINA 99 58
InvivoChem
+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
TargetMol Chemicals Inc.
support@targetmol.com United States 38631 58

View Lastest Price from Methicillin Sodium Salt manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Methicillin sodium salt pictures 2024-11-19 Methicillin sodium salt
132-92-3
US $29.00 / mg 93.8% 10g TargetMol Chemicals Inc.
Methicillin sodium salt pictures 2024-11-19 Methicillin sodium salt
132-92-3
US $29.00 / mg 93.8% 10g TargetMol Chemicals Inc.
Methicillin Sodium Salt pictures 2021-07-16 Methicillin Sodium Salt
132-92-3
US $0.00-0.00 / g 100mg 98% >1kg Shanghai kingmorn biotechnology Co.,LTD.

132-92-3(Methicillin Sodium Salt)Related Search:

Methicillin sodium salt Sodium (2,6-dimethoxyphenyl)penicillin, Sodium methicillin (2S,5R,6R)-6-[(2,6-Dimethoxybenzoyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid sodium salt 6α-[(2,6-Dimethoxybenzoyl)amino]penicillanic acid sodium salt Sodium (2,6-dimethoxyphenyl)penicillin Sodium methicillin Meticillin sodium salt meticillin sodium sodium 6-(2,6-dimethoxybenzamido)penicillanate Methicillin sodium Methicillin Sodium Salt USP/EP/BP METHICILLIN SODIUM USP/EP/BP Sodium (2S,5R,6R)-6-(2,6-dimethoxybenzamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate TIANFU-CHEM -sodium 6-(2,6-dimethoxybenzamido)penicillanate Meticillin,Methicillin sodium salt,intracellular infection,infection,β-lactam,Antibiotic,inhibit,Methicillin,Bacterial,inflammation,penicillin,semi-synthetic antibiotic,Inhibitor 132-92-3 C17H19N2NaO6S C17H19N2O6SNa Chiral Reagents Heterocycles Intermediates & Fine Chemicals Pharmaceuticals Sulfur & Selenium Compounds STAPHCILLIN