Benzenesulfonamide, 2,6-dimethoxy-N-[4-methoxy-6-(1H-pyrazol-1-ylmethyl)-1,2-benzisoxazol-3-yl]-

Benzenesulfonamide, 2,6-dimethoxy-N-[4-methoxy-6-(1H-pyrazol-1-ylmethyl)-1,2-benzisoxazol-3-yl]- structure

CAS No.: 2569009-58-9

Chemical Name:: Benzenesulfonamide, 2,6-dimethoxy-N-[4-methoxy-6-(1H-pyrazol-1-ylmethyl)-1,2-benzisoxazol-3-yl]-

Synonyms: CTX-3648;PF-9363 (CTx-648);2,6-dimethoxy-N-[4-methoxy-6-(1H-pyrazol-1 -ylmethyl)-1,2-benzoxazol-3-yl]benzenesulfonamide;2,6-dimethoxy-N-[4-methoxy-6-(1H-pyrazol-1-ylmethyl)-1,2-benzisoxazol-3-yl]-benzenesulfonamide;N-(6-((1H-Pyrazol-1-yl)methyl)-4-methoxybenzo[d]isoxazol-3-yl)-2,6-dimethoxybenzenesulfonamide;Benzenesulfonamide, 2,6-dimethoxy-N-[4-methoxy-6-(1H-pyrazol-1-ylmethyl)-1,2-benzisoxazol-3-yl]-;CTx-648,cancer,patient-derived,anti-tumor,HAT,CTx648,Inhibitor,HATs,selective,xenograft,CTx 648,Histone Acetyltransferase,PF9363,inhibit,PF 9363,potent,PF-9363

CBNumber:: CB49014266

Molecular Formula:: C20H20N4O6S

Molecular Weight:: 444.46

MDL Number:: MFCD34474252

MOL File:: 2569009-58-9.mol

Last updated:2024-11-19 20:33:22

Request For Quotation

Benzenesulfonamide, 2,6-dimethoxy-N-[4-methoxy-6-(1H-pyrazol-1-ylmethyl)-1,2-benzisoxazol-3-yl]- Properties

Boiling point	692.0±65.0 °C(Predicted)
Density	1.43±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
form	Solid
pka	6.34±0.30(Predicted)
color	White to off-white

Benzenesulfonamide, 2,6-dimethoxy-N-[4-methoxy-6-(1H-pyrazol-1-ylmethyl)-1,2-benzisoxazol-3-yl]- Chemical Properties,Uses,Production

Biological Activity

PF-9363 (CTx-648) is a first-in-class potent and high selective KAT6A/KAT6B inhibitor. PF-9363 can be used for the research of cancer[1][2]. PF-9363 (0~1 μM; 1 day; ZR75-1, T47D and MCF7 cells) down-regulates the expression of H3K23Ac biomarker[1].PF-9363 leads to down regulation of a specific set of genes involved in ESR1 pathway, cell cycle and stem cell pathways. PF-9363 shows that the IC50 values for ZR75-1 and T47D are 0.3 nM and 0.9 nM[1]. PF-9363 shows strong anti-tumor activity in patient-derived xenograft models[1].

References

[1]. Shikhar S, et al. First-in-class KAT6A/KAT6B Inhibitor CTx-648 (PF-9363) Demonstrates Potent Anti-tumor Activity in ER+ Breast Cancer with KAT6A Dysregulation [2]. WO2020254946

Benzenesulfonamide, 2,6-dimethoxy-N-[4-methoxy-6-(1H-pyrazol-1-ylmethyl)-1,2-benzisoxazol-3-yl]- Preparation Products And Raw materials

Raw materials

Preparation Products

Benzenesulfonamide, 2,6-dimethoxy-N-[4-methoxy-6-(1H-pyrazol-1-ylmethyl)-1,2-benzisoxazol-3-yl]- Suppliers

Global( 34)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32957	60
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32165	58
Shanghai UCHEM Inc.	+862156762820 +86-13564624040	sales@myuchem.com	China	7514	58
TargetMol Chemicals Inc.		support@targetmol.com	United States	38632	58
Wuhan Jingkang en Biomedical Technology Co., Ltd	+8613720134139	orders@jknbiochem.com	China	5221	58
Shanghai Maiev Biotech Co.,Ltd	+86-13671830408 +86-13671830408	maievbiotech2@163.com	China	79	58
Shanghai Lollane Biological Technology Co.,Ltd.	021-52996696，15000506266 15000506266		China	4512	55
ATK CHEMICAL COMPANY LIMITED	021-51619050 13301662590	mandy@atkchemical.com	China	8026	55
ShangHai Biochempartner Co.,Ltd	177-54423994 17754423994	2853530910@QQ.com	China	8011	62
Shanghai Chaolan Chemical Technology Center	021-QQ：65489617 15618227136	Sales@ATKchemical.com	China	7267	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
TargetMol Chemicals Inc.	58
Shanghai UCHEM Inc.	58
TargetMol Chemicals Inc.	58
Wuhan Jingkang en Biomedical Technology Co., Ltd	58
Shanghai Maiev Biotech Co.,Ltd	58
Shanghai Lollane Biological Technology Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	55
ShangHai Biochempartner Co.,Ltd	62
Shanghai Chaolan Chemical Technology Center	58

View Lastest Price from Benzenesulfonamide, 2,6-dimethoxy-N-[4-methoxy-6-(1H-pyrazol-1-ylmethyl)-1,2-benzisoxazol-3-yl]- manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2024-11-19	PF-9363 2569009-58-9	US $67.00-263.00 / mg		99.25%	10g	TargetMol Chemicals Inc.

PF-9363
2569009-58-9
US $67.00-263.00 / mg
99.25%
TargetMol Chemicals Inc.

Benzenesulfonamide, 2,6-dimethoxy-N-[4-methoxy-6-(1H-pyrazol-1-ylmethyl)-1,2-benzisoxazol-3-yl]- CTX-3648 2,6-dimethoxy-N-[4-methoxy-6-(1H-pyrazol-1 -ylmethyl)-1,2-benzoxazol-3-yl]benzenesulfonamide CTx-648,cancer,patient-derived,anti-tumor,HAT,CTx648,Inhibitor,HATs,selective,xenograft,CTx 648,Histone Acetyltransferase,PF9363,inhibit,PF 9363,potent,PF-9363 N-(6-((1H-Pyrazol-1-yl)methyl)-4-methoxybenzo[d]isoxazol-3-yl)-2,6-dimethoxybenzenesulfonamide PF-9363 (CTx-648) 2,6-dimethoxy-N-[4-methoxy-6-(1H-pyrazol-1-ylmethyl)-1,2-benzisoxazol-3-yl]-benzenesulfonamide 2569009-58-9