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Ethanol, 2-[[[2-methoxy-6-(2-methyl[1,1'-biphenyl]-3-yl)-3-pyridinyl]methyl]amino]-

Ethanol, 2-[[[2-methoxy-6-(2-methyl[1,1'-biphenyl]-3-yl)-3-pyridinyl]methyl]amino]- structure

CAS No.: 2628506-54-5

Chemical Name:: Ethanol, 2-[[[2-methoxy-6-(2-methyl[1,1'-biphenyl]-3-yl)-3-pyridinyl]methyl]amino]-

Synonyms: PD-1/PD-L1-IN-9;PD1/PDL1IN9,PD 1/PD L1 IN 9;Ethanol, 2-[[[2-methoxy-6-(2-methyl[1,1'-biphenyl]-3-yl)-3-pyridinyl]methyl]amino]-

CBNumber:: CB49280489

Molecular Formula:: C22H24N2O2

Molecular Weight:: 348.44

MDL Number:

MOL File:: 2628506-54-5.mol

Last updated:2024-11-19 15:53:33

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Ethanol, 2-[[[2-methoxy-6-(2-methyl[1,1'-biphenyl]-3-yl)-3-pyridinyl]methyl]amino]- Properties

Boiling point	498.5±45.0 °C(Predicted)
Density	1.127±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO : 100 mg/mL (286.99 mM; Need ultrasonic)
form	Solid
pka	14.68±0.10(Predicted)
color	White to off-white

Ethanol, 2-[[[2-methoxy-6-(2-methyl[1,1'-biphenyl]-3-yl)-3-pyridinyl]methyl]amino]- Chemical Properties,Uses,Production

Biological Activity

PD-1/PD-L1-IN-9 is a potent and orally active inhibitor of PD-1/PD-L1 interaction, with an IC50 of 3.8 nM. PD-1/PD-L1-IN-9 can enhance the killing activity of tumor cells by immune cells. PD-1/PD-L1-IN-9 also exhibits significant in vivo antitumor activity in a CT26 mouse model[1]. PD-1/PD-L1-IN-9 (compound 24) (46.9-1500 nM; pretreated for 2 h) dose-dependently significantly activates the antitumor immunity of PBMCs to MDB-MB 231 cells, with an EC50 of ～100 nM[1]. PD-1/PD-L1-IN-9 (compound 24) (40-80 mg/kg; p.o. once a day for 2 weeks) inhibits tumor growth in a dose-dependent manner and does not cause any body weight loss or mortality of mice[1].PD-1/PD-L1-IN-9 (3 mg/kg; a single i.v.) exhibits half-life (t1/2=4.2 h), plasma clearance (Cl=11.5 L/h/kg) and Cmax (1233 ng/mL) in rats[1].PD-1/PD-L1-IN-9 (25 mg/kg; a single p.o.) exhibits moderate oral bioavailability (F=22 %), half-life (t1/2=6.4 h) and Cmax (192 ng/mL) in rats[1].

References

[1]. Wang T, et, al. Novel Biphenyl Pyridines as Potent Small-Molecule Inhibitors Targeting the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Interaction. J Med Chem. 2021 May 30.

Ethanol, 2-[[[2-methoxy-6-(2-methyl[1,1'-biphenyl]-3-yl)-3-pyridinyl]methyl]amino]- Preparation Products And Raw materials

Raw materials

Preparation Products

Ethanol, 2-[[[2-methoxy-6-(2-methyl[1,1'-biphenyl]-3-yl)-3-pyridinyl]methyl]amino]- Suppliers

Global( 4)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32161	58
Shanghai Yifei Biotechnology Co. , Ltd.	021-65675885 18964387627	customer_service@efebio.com	China	11974	58
RD International Technology Co., Limited	18024082417	market@ubiochem.com	China	9266	58
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	19703	58

Supplier	Advantage
TargetMol Chemicals Inc.	58
Shanghai Yifei Biotechnology Co. , Ltd.	58
RD International Technology Co., Limited	58
TargetMol Chemicals Inc.	58

View Lastest Price from Ethanol, 2-[[[2-methoxy-6-(2-methyl[1,1'-biphenyl]-3-yl)-3-pyridinyl]methyl]amino]- manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2024-11-19	PD-1/PD-L1-IN-9 2628506-54-5	US $55.00-136.00 / mg		99.37%	10g	TargetMol Chemicals Inc.

PD-1/PD-L1-IN-9
2628506-54-5
US $55.00-136.00 / mg
99.37%
TargetMol Chemicals Inc.

Ethanol, 2-[[[2-methoxy-6-(2-methyl[1,1'-biphenyl]-3-yl)-3-pyridinyl]methyl]amino]- Spectrum

Ethanol, 2-[[[2-methoxy-6-(2-methyl[1,1'-biphenyl]-3-yl)-3-pyridinyl]methyl]amino]-(2628506-54-5)¹HNMR

Ethanol, 2-[[[2-methoxy-6-(2-methyl[1,1'-biphenyl]-3-yl)-3-pyridinyl]methyl]amino]- PD-1/PD-L1-IN-9 PD1/PDL1IN9,PD 1/PD L1 IN 9 2628506-54-5