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GSK-2879552.2HCl

GSK-2879552.2HCl structure

CAS No.: 1902123-72-1

Chemical Name:: GSK-2879552.2HCl

Synonyms: 4-((4-((((1R,2S)-2-Phenylcyclopropyl)amino)methyl)piperidin-1-yl)methyl)benzoic acid dihydrochloride;Benzoic acid, 4-[[4-[[[(1R,2S)-2-phenylcyclopropyl]amino]methyl]-1-piperidinyl]methyl]-, hydrochloride (1:2)

CBNumber:: CB49318115

Molecular Formula:: C23H29ClN2O2

Molecular Weight:: 400.95

MDL Number:

MOL File:: 1902123-72-1.mol

Last updated:2024-07-02 08:55:09

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GSK-2879552.2HCl Properties

storage temp.	Store at -20°C
solubility	DMSO : 50 mg/mL (114.31 mM; Need ultrasonic)
form	Solid
color	White to off-white

GSK-2879552.2HCl Chemical Properties,Uses,Production

Biological Activity

GSK2879552 dihydrochloride an orally active, selective and irreversible inhibitor of lysine specific demethylase 1 (LSD1/KDM1A), with potential antineoplastic activity[1][2]. GSK2879552 inhibits KDM1A histone demethylase activity, inducing differentiation of sorafenib-resistant cells and attenuates stemness properties. GSK2879552 depresses the transcription of Wnt antagonists and downregulates β-catenin signaling activity in sorafenib-resistant cells[1]. GSK2879552 (1.5 mg/kg, p.o.) treatment exhibits tumor growth inhibition in SCLC xenograft bearing mice[2].

References

[1]. Huang M, et al. Targeting KDM1A attenuates Wnt/β-catenin signaling pathway to eliminate sorafenib-resistant stem-like cells in hepatocellular carcinoma. Cancer Lett. 2017 Apr 2;398:12-21. [2]. Mohammad HP, et al. A DNA Hypomethylation Signature Predicts Antitumor Activity of LSD1 Inhibitors in SCLC. Cancer Cell. 2015 Jul 13;28(1):57-69.

GSK-2879552.2HCl Preparation Products And Raw materials

Raw materials

Preparation Products

GSK-2879552.2HCl Suppliers

Global( 7)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	57511	58
Dalian Meilun Biotech Co., Ltd.	0411-62910999 13889544652	sales@meilune.com	China	4665	58
Bide Pharmatech Ltd.	400-1647117 15221909166	product02@bidepharm.com	China	63720	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	24017	58
Nanjing Tengyi Biotechnology Co., Ltd	025-58851786 17714337195	sales@tybiochem.com	China	5593	58
Shanghai Aladdin Biochemical Technology Co.,Ltd.	+86-18521732826	market@aladdin-e.com	China	48467	58
RD International Technology Co., Limited	18024082417	market@ubiochem.com	China	9294	58

Supplier	Advantage
Aladdin Scientific	58
Dalian Meilun Biotech Co., Ltd.	58
Bide Pharmatech Ltd.	58
TargetMol Chemicals Inc.	58
Nanjing Tengyi Biotechnology Co., Ltd	58
Shanghai Aladdin Biochemical Technology Co.,Ltd.	58
RD International Technology Co., Limited	58

Benzoic acid, 4-[[4-[[[(1R,2S)-2-phenylcyclopropyl]amino]methyl]-1-piperidinyl]methyl]-, hydrochloride (1:2) 4-((4-((((1R,2S)-2-Phenylcyclopropyl)amino)methyl)piperidin-1-yl)methyl)benzoic acid dihydrochloride 1902123-72-1