ChemicalBook >> CAS DataBase List >>4-amino-5-(tosyloxy)naphthalene-2,7-disulfonic acid
4-amino-5-(tosyloxy)naphthalene-2,7-disulfonic acid
- CAS No.
- 6837-93-0
- Chemical Name:
- 4-amino-5-(tosyloxy)naphthalene-2,7-disulfonic acid
- Synonyms
- NSC16168,NSC-16168;4-amino-5-(tosyloxy)naphthalene-2,7-disulfonic acid;1-Amino-8-(4-methylphenylsulfonyloxy)naphthalene-3,6-disulfonic acid;4-amino-5-(4-methylphenyl)sulfonyloxynaphthalene-2,7-disulfonic acid;8-Amino-1-(4-methylphenylsulfonyloxy)-3,6-naphthalenedisulfonic acid;4-Amino-5-[[(4-methylphenyl)sulfonyl]oxy]-2,7-naphthalenedisulfonic acid;2,7-Naphthalenedisulfonic acid, 4-amino-5-[[(4-methylphenyl)sulfonyl]oxy]-
- CBNumber:
- CB4968018
- Molecular Formula:
- C17H15NO9S3
- Molecular Weight:
- 473.5
- MDL Number:
- MOL File:
- 6837-93-0.mol
- MSDS File:
- SDS
Last updated:2024-07-02 08:55:09
4-amino-5-(tosyloxy)naphthalene-2,7-disulfonic acid Chemical Properties,Uses,Production
Biological Activity
NSC16168 is a specific ERCC1-XPF inhibitor with IC50 value of 0.42 μM. It inhibits DNA repair and enhances the efficacy of CDDP in cancer.
in vitro
NSC16168 (0-50 μM) potentiates cisplatin efficacy in cancer cells.
Cell Viability Assay.
| H460 cells. | |||||
| Concentration: | 0-50 μM. | ||||
| Incubation Time: | 2 h. | ||||
| Result: | Potentiated cisplatin efficacy in cancer cells. |
| Animal Model: | 2.5×10 6 H460 cells were injected sc in the right flank of each mouse. |
| Dosage: | 20 mg/kg. |
| Administration: | IP, twice daily for 10 days. |
| Result: | The tumor growth was minimally affected by compound and the mice displayed no signs of distress or toxic side effects. The combination treatment with 16168 and cisplatin inhibited H460 tumor growth, which was maintained for the duration of the compound injections. |
target
IC50: 0.42 μM (ERCC1-XPF).
4-amino-5-(tosyloxy)naphthalene-2,7-disulfonic acid Preparation Products And Raw materials
Global( 18)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Beijing Solarbio Science & Tecnology Co., Ltd. | 010-50973130 4009686088 | 3193328036@qq.com | China | 29786 | 68 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| Zhengzhou anmousse chemical products co. LTD | 0371-55289822 18737195735 | 483339295@qq.com | China | 7096 | 58 |
| Guangzhou Younan Technology Co., Ltd | 020-020-82000279 18988968278 | sales@ubiochem.com | China | 4324 | 58 |
| Shanghai hongqu biomedical technology co. LTD | 88888888888 | hongquchem@qq.com | China | 5132 | 58 |
| Chunchuang (Wuhan) Technology Co., Ltd | 15342225168 | yutianchun2007@126.com | China | 10005 | 58 |
| Krain Pharmaceutical Technology CO.,Ltd | 18252089365 | Krain_kerun@163.com | China | 2632 | 58 |
| cjbscvictory | 13348960310 13348960310 | 3003867561@qq.com | China | 10000 | 58 |
4-amino-5-(tosyloxy)naphthalene-2,7-disulfonic acid
1-Amino-8-(4-methylphenylsulfonyloxy)naphthalene-3,6-disulfonic acid
4-Amino-5-[[(4-methylphenyl)sulfonyl]oxy]-2,7-naphthalenedisulfonic acid
8-Amino-1-(4-methylphenylsulfonyloxy)-3,6-naphthalenedisulfonic acid
4-amino-5-(4-methylphenyl)sulfonyloxynaphthalene-2,7-disulfonic acid
2,7-Naphthalenedisulfonic acid, 4-amino-5-[[(4-methylphenyl)sulfonyl]oxy]-
NSC16168,NSC-16168
6837-93-0