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Amycolatopsin A
- CAS No.
- 2209112-96-7
- Chemical Name:
- Amycolatopsin A
- Synonyms
- Amycolatopsin A;(3E,5E,7E,11E,13E,15E)-20-((R)-1-((2S,3R,4R,5S,6R)-5-(((2S,4S,5S,6R)-5-(((2S,4R,5R,6R)-4,5-dihydroxy-4,6-dimethyltetrahydro-2H-pyran-2-yl)oxy)-4-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-2,4-dihydroxy-3-methoxy-6-(3-methoxypropyl)-5-methyltetrahydro-2H-pyran-2-yl)ethyl)-10-(((2S,3R,4R,5S,6R)-3,4-dihydroxy-5-methoxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-17-hydroxy-7-(hydroxymethyl)-5,18-dimethoxy-3,9,11,13,15-pentamethyloxacycloicosa-3,5,7,11,13,15-hexaen-2-one
- CBNumber:
- CB49739301
- Molecular Formula:
- C60H98O23
- Molecular Weight:
- 1187.42
- MDL Number:
- MOL File:
- 2209112-96-7.mol
Last updated:2023-05-21 10:59:17
Amycolatopsin A Chemical Properties,Uses,Production
Biological Activity
Amycolatopsin A is a macrolide polyketide originally isolated from Amycolatopsis that has antimycobacterial and anticancer activities.1 It is active against M. bovis and M. tuberculosis (IC50s = 0.4 and 4.4 μM, respectively) but not B. subtilis, S. aureus, E. coli, or P. aeruginosa (IC50s = >30 μM for all). Amycolatopsin A is cytotoxic to SW620 colorectal and NCI H460 lung cancer cells (IC50s = 0.08 and 1.2 μM, respectively).
References
1.Khalil, Z.G., Salim, A.A., Vuong, D., et al.Amycolatopsins A-C: Antimycobacterial glycosylated polyketide macrolides from the Australian soil Amycolatopsis sp. MST-108494J. Antibiot. (Tokyo)70(12)1097-1103(2017)
Amycolatopsin A Preparation Products And Raw materials
Raw materials
Preparation Products
Amycolatopsin A Suppliers
Global( 6)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 14059 | 65 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9707 | 58 |
| ChemeGen 中国 | 18818260767 | sales@chemegen.com | China | 6975 | 58 |
| Beijing Biocreative Technology Co., Ltd. | 15522676233 | 3007606172@qq.com | China | 1249 | 58 |
| Nanjing Shizhou Biology Technology Co.,Ltd | 025-85560043 15850508050 | cindy.huang@synzest.com | China | 12007 | 58 |
| Supplier | Advantage |
|---|---|
| BOC Sciences | 65 |
| Shanghai EFE Biological Technology Co., Ltd. | 58 |
| ChemeGen 中国 | 58 |
| Beijing Biocreative Technology Co., Ltd. | 58 |
| Nanjing Shizhou Biology Technology Co.,Ltd | 58 |
Amycolatopsin A
(3E,5E,7E,11E,13E,15E)-20-((R)-1-((2S,3R,4R,5S,6R)-5-(((2S,4S,5S,6R)-5-(((2S,4R,5R,6R)-4,5-dihydroxy-4,6-dimethyltetrahydro-2H-pyran-2-yl)oxy)-4-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-2,4-dihydroxy-3-methoxy-6-(3-methoxypropyl)-5-methyltetrahydro-2H-pyran-2-yl)ethyl)-10-(((2S,3R,4R,5S,6R)-3,4-dihydroxy-5-methoxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-17-hydroxy-7-(hydroxymethyl)-5,18-dimethoxy-3,9,11,13,15-pentamethyloxacycloicosa-3,5,7,11,13,15-hexaen-2-one
2209112-96-7