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Talinolol

CAS No.
57460-41-0
Chemical Name:
Talinolol
Synonyms
Cordanum;rac-Talinolol ;Racemic talinolol;1-(4-(Cyclohexylureido)phenoxy)-3-(tert-butylamino)-2-propanol;1-(4-Cyclohexylureidophenoxy)-2-hydroxy-3-tert-butylaminopropane;1-(3-(3-Cyclohexylureido)phenoxy)-3-(tert-butylamino)-2-propanol;1-(4-(3-(tert-butylaMino)-2-hydroxypropoxy)phenyl)-3-cyclohexylu;1-(4-(3-(tert-butylamino)-2-hydroxypropoxy)phenyl)-3-cyclohexylurea;1-(2-(3-(tert-butylamino)-2-hydroxypropoxy)phenyl)-3-cyclohexylurea;(+-)-1-(p-(3-(tert-Butylamino)-2-hydroxypropoxy)phenyl)-3-cyclohexylurea
CBNumber:
CB51073789
Molecular Formula:
C20H33N3O3
Molecular Weight:
363.49
MDL Number:
MFCD00864592
MOL File:
57460-41-0.mol
Last updated:2023-05-18 11:31:19

Talinolol Properties

Melting point 160-162°C
Boiling point 520.0±50.0 °C(Predicted)
Density 1.11±0.1 g/cm3(Predicted)
storage temp. -20°C Freezer
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
pka 13.82±0.20(Predicted)
color White to Pale Pink
FDA UNII 3S82268BKG

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501
HazardClass  IRRITANT
Toxicity LD50 in rats, mice (mg/kg): 1180, 593 orally; 54.3, 74.7 i.p.; 29.7, 25.0 i.v. (Femmer)

Talinolol price More Price(12)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML3412 Talinolol ≥95% (HPLC) 57460-41-0 5MG $64.8 2024-03-01 Buy
Sigma-Aldrich SML3412 Talinolol ≥95% (HPLC) 57460-41-0 25MG $261 2024-03-01 Buy
Cayman Chemical 16116 (±)-Talinolol ≥95% 57460-41-0 1mg $44 2024-03-01 Buy
Cayman Chemical 16116 (±)-Talinolol ≥95% 57460-41-0 5mg $183 2024-03-01 Buy
Cayman Chemical 16116 (±)-Talinolol ≥95% 57460-41-0 10mg $341 2024-03-01 Buy
Product number Packaging Price Buy
SML3412 5MG $64.8 Buy
SML3412 25MG $261 Buy
16116 1mg $44 Buy
16116 5mg $183 Buy
16116 10mg $341 Buy

Talinolol Chemical Properties,Uses,Production

Description

(±)-Talinolol is a β1-selective adrenoceptor antagonist well known for its cardioprotective and antihypertensive activity. By blocking β1-adrenergic receptors, talinolol delays the conduction of stimuli in the AV node, reduces the sino-atrial conduction time, and impedes the sinus node automaticity. Because its metabolism in human liver microsomes is well understood, (±)-talinolol is useful for examining the activity of the drug-transporting MDR1 gene product P-glycoprotein.

Chemical Properties

Off-White to Pale Pink Solid

Uses

Selective β1-adrenergic blocker structurally related to Practolol. Antihypertensive; antiarrhythmic.

Definition

ChEBI: Talinolol is a member of ureas.

References

[1] abmann i. the actions of talinolol, a β1-selective beta blocker, in cardiac arrhythmia and acute myocardial infarction[j]. current medical research and opinion, 2008, 13(6): 325-342.
[2] trausch b, oertel r, richter k, et al. disposition and bioavailability of the β1‐adrenoceptor antagonist talinolol in man[j]. biopharmaceutics & drug disposition, 1995, 16(5): 403-414.

Talinolol Preparation Products And Raw materials

Raw materials

Preparation Products

Talinolol Suppliers

Global( 37)Suppliers
Supplier Tel Email Country ProdList Advantage
BOC Sciences
+1-631-485-4226 inquiry@bocsci.com United States 19553 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32161 58
Amadis Chemical Company Limited
571-89925085 sales@amadischem.com China 131957 58
Tianjin Zhongtian Xinchuang Technology Co., Ltd. 13312191509 1932163312@qq.com China 292 58
J & K SCIENTIFIC LTD. 010-82848833 400-666-7788 jkinfo@jkchemical.com China 94657 76
Chemsky(shanghai)International Co.,Ltd. 021-50135380 shchemsky@sina.com China 32321 50
S.Z. PhyStandard Bio-Tech. Co., Ltd. 0755-4000505016 13380397412 3001272453@qq.com China 5047 50
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9806 58
Shenzhen Polymeri Biochemical Technology Co., Ltd. +86-400-002-6226 +86-13028896684; sales@rrkchem.com China 57423 58
Nanjing Meihao Pharmaceutical Technology Co., Ltd. meitaochem@126.com meitaochem@126.com China 19103 58
1-(3-(3-Cyclohexylureido)phenoxy)-3-(tert-butylamino)-2-propanol 1-(4-(Cyclohexylureido)phenoxy)-3-(tert-butylamino)-2-propanol 1-(4-Cyclohexylureidophenoxy)-2-hydroxy-3-tert-butylaminopropane Cordanum Racemic talinolol rac-Talinolol 1-(4-(3-(tert-butylamino)-2-hydroxypropoxy)phenyl)-3-cyclohexylurea 1-(4-(3-(tert-butylaMino)-2-hydroxypropoxy)phenyl)-3-cyclohexylu ( -)-1-(4-(3-(tert-Butylamino)-2-hydroxypropoxy)phenyl)-3-cyclohexylharnstoff (+-)-1-(p-(3-(tert-Butylamino)-2-hydroxypropoxy)phenyl)-3-cyclohexylurea 1-(2-(3-(tert-butylamino)-2-hydroxypropoxy)phenyl)-3-cyclohexylurea Talinolol,Beta Receptor,Adrenergic Receptor,antihypertensive,inhibit,Cordanum,Inhibitor,P-glycoprotein,cardioprotective,P-gp 57460-41-0 C20H33N3O3 Amines Aromatics Intermediates & Fine Chemicals Pharmaceuticals