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3-(4-Nitro-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione

3-(4-Nitro-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione structure

CAS No.: 827026-45-9

Chemical Name:: 3-(4-Nitro-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione

Synonyms: 3-(4-nitro-1-oxoisoindolin-2-yl)piperidine-2,6-dione;6-Piperidinedione;4-Nitro LenalidoMide;Lenalidomide Impurity B;Lenalidomide Impurities05;Lenalidomide EP Impurity B;Lenalidomide 4-Nitro Impurity;3-(4-Nitro-1-oxo-1, 3-dihydro-isoindol-;3-dihydro-4-nitro-1-oxo-2H-isoindol-2-yl)-;3-(4-Nitro-1-oxoisoindolin-2-yl)piperidin-2,6-dione

CBNumber:: CB51075415

Molecular Formula:: C13H11N3O5

Molecular Weight:: 289.24

MDL Number:: MFCD11977267

MOL File:: 827026-45-9.mol

MSDS File:: SDS

Last updated:2023-09-20 10:53:23

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3-(4-Nitro-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione Properties

Melting point	>250°C (dec.)
Boiling point	616.6±55.0 °C(Predicted)
Density	1.546±0.06 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
solubility	DMSO (Slightly, Heated), Methanol (Slightly)
form	Solid
pka	10.55±0.40(Predicted)
color	Beige to Brown
InChI	InChI=1S/C13H11N3O5/c17-11-5-4-10(12(18)14-11)15-6-8-7(13(15)19)2-1-3-9(8)16(20)21/h1-3,10H,4-6H2,(H,14,17,18)
InChIKey	JKPJLYIGKKDZDT-UHFFFAOYSA-N
SMILES	N1C(=O)CCC(N2CC3=C(C2=O)C=CC=C3[N+]([O-])=O)C1=O
FDA UNII	5CBC4TCM54

SAFETY

Risk and Safety Statements

HazardClass	IRRITANT

3-(4-Nitro-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	N496395	4-NitroLenalidomide	827026-45-9	10mg	$205	2021-12-16	Buy
TRC	N496395	4-NitroLenalidomide	827026-45-9	100mg	$1620	2021-12-16	Buy
American Custom Chemicals Corporation	CHM0079673	3-(4-NITRO-1-OXO-1,3-DIHYDROISOINDOL-2-YL)PIPERIDINE-2,6-DIONE 95.00%	827026-45-9	1G	$2194.5	2021-12-16	Buy
Medical Isotopes, Inc.	47895	4-NitroLenalidomide	827026-45-9	1g	$2400	2021-12-16	Buy
ChemScene	CS-M1824	3-(4-Nitro-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione 99.97%	827026-45-9	10g	$561	2021-12-16	Buy

Product number	Packaging	Price	Buy
N496395	10mg	$205	Buy
N496395	100mg	$1620	Buy
CHM0079673	1G	$2194.5	Buy
47895	1g	$2400	Buy
CS-M1824	10g	$561	Buy

3-(4-Nitro-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione Chemical Properties,Uses,Production

Chemical Properties

White crystalline

Uses

3-(4-Nitro-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione, also known as 4-Nitro Lenalidomide, is a Lenalidomide (L328000) analog. It is an impurity and intermediate of Lenalidomide.

Preparation

3-aminopiperidine-2,6-dione hydrochloride (III) (25 g, 0.15 mol) and dimethyl sulfoxide (150 mL) were charged into 500 mL 3N RBF. Triethylamine (62 g, 0.61 mol) was added slowly to the above reaction mixture under nitrogen over 10 min. Methyl 2-(bromomethyl)-3-nitrobenzoate (II) (45.8 g, 0.16 mol) of example 3 dissolved in dimethyl sulfoxide (50 mL) was added to the reaction mixture under nitrogen over 20 min and heated to 50-55 °C. 3-(4-Nitro-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione was obtained by purification.

3-(4-Nitro-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione Preparation Products And Raw materials

Raw materials

Preparation Products

Lenalidomide

3-(4-Nitro-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione Suppliers

Global( 265)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
JUYE XIANDAI fine chemistry Co.,Ltd	+86-18958038633; +8618958038633	tony@sdhypharma.com	China	64	58
Huanfu Industrial Co.，（Shanghai）Ltd.	+86-18001856580 +86-18001856580	2415195517@qq.com	China	43	58
SHANDONG BOYUAN PHARMACEUTICAL CO., LTD.	+86-0531-69954981 +8615666777973	dwyane.wang@boyuanpharm.com	China	211	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29791	60
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1803	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21634	55
Nanjing Finetech Chemical Co., Ltd.	025-85710122 17714198479	sales@fine-chemtech.com	CHINA	885	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29880	58
Jinan Shengqi pharmaceutical Co,Ltd	86+18663751872	christine@shengqipharm.com	CHINA	491	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28172	58

Supplier	Advantage
JUYE XIANDAI fine chemistry Co.,Ltd	58
Huanfu Industrial Co.，（Shanghai）Ltd.	58
SHANDONG BOYUAN PHARMACEUTICAL CO., LTD.	58
Capot Chemical Co.,Ltd.	60
Beijing Cooperate Pharmaceutical Co.,Ltd	55
Henan Tianfu Chemical Co.,Ltd.	55
Nanjing Finetech Chemical Co., Ltd.	55
career henan chemical co	58
Jinan Shengqi pharmaceutical Co,Ltd	58
Hubei Jusheng Technology Co.,Ltd.	58

View Lastest Price from 3-(4-Nitro-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-08-26	3-(4-Nitro-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione 827026-45-9	US $0.00-0.00 / kg	1kg	99.8%	9000	SHANDONG BOYUAN PHARMACEUTICAL CO., LTD.
2022-10-11	3-(4-Nitro-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione 827026-45-9	US $0.00-0.00 / KG	1KG	98%	1ton	Henan Aochuang Chemical Co.,Ltd.
2021-07-13	3-(4-Nitro-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione 827026-45-9	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd

3-(4-Nitro-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione
827026-45-9
US $0.00-0.00 / kg
99.8%
SHANDONG BOYUAN PHARMACEUTICAL CO., LTD.

3-(4-Nitro-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione
827026-45-9
US $0.00-0.00 / KG
98%
Henan Aochuang Chemical Co.,Ltd.

3-(4-Nitro-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione
827026-45-9
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

827026-45-9(3-(4-Nitro-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione)Related Search:

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Lenalidomide Impurity 13 METHYL 2-BROMOMETHYL-6-NITRO-BENZOATE Lenalidomide Impurity 7 Hydroxy Lenalidomide Methyl 2-methyl-3-nitrobenzoate

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3-(4-Nitro-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione 3-(4-Nitro-1-oxoisoindolin-2-yl)piperidin-2,6-dione 4-Nitro LenalidoMide 3-dihydro-4-nitro-1-oxo-2H-isoindol-2-yl)- 6-Piperidinedione 3-(4-nitro-1-oxo-2,3-dihydro-1H-isoindol-2-yl)piperidine-2,6-dione 3-(1,3-Dihydro-4-nitro-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione 3-(4-Nitro-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione (3S)-3-(4-Nitro-1-oxo-1,3-dihydro-2H-isoindol-2-yl)piperidine-2,6-dione 2,6-Piperidinedione, 3-(1,3-dihydro-4-nitro-1-oxo-2H-isoindol-2-yl)- 3-(1-keto-4-nitro-isoindolin-2-yl)piperidine-2,6-quinone 3-(4-nitro-1-oxo-2-isoindolinyl)piperidine-2,6-dione 3-(7-nitro-3-oxo-1H-isoindol-2-yl)piperidine-2,6-dione Lenalidomide Impurity B 3-(4-Nitro-1-oxo-1, 3-dihydro-isoindol- 3-(4-Nitro-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2 Lenalidomide EP Impurity B Lenalidomide 4-Nitro Impurity 3-(4-Nitro-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dio... Lenalidomide Impurities05 Lenalidomide Impurity BQ: What is Lenalidomide Impurity B Q: What is the CAS Number of Lenalidomide Impurity B Q: What is the storage condition of Lenalidomide Impurity B 3-(4-nitro-1-oxoisoindolin-2-yl)piperidine-2,6-dione 3-（4′-Nitroisondoline-1′-One）-1-Piperidine-2,6-Dione 3-(1-Oxo-4-nitro-1,3-Dihydro-isoindole-2-yl)piperidine-2,6-dione 827026-45-9 Amines Heterocycles Intermediates & Fine Chemicals Pharmaceuticals