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Fesoterodinefumarate

CAS No.
286930-03-8
Chemical Name:
Fesoterodinefumarate
Synonyms
Toviaz;CS-102;CS-244;SPM 907;Spm 8272;SMP 8272;Unii-eos72165S7;Fesoterodinefumarate;PF-00695838 fumarate;Fesoterodine maleate
CBNumber:
CB51075581
Molecular Formula:
C30H41NO7
Molecular Weight:
527.65
MDL Number:
MFCD12756004
MOL File:
286930-03-8.mol
MSDS File:
SDS
Last updated:2024-11-19 15:53:33

Fesoterodinefumarate Properties

Melting point 72-78°C
storage temp. Inert atmosphere,2-8°C
solubility DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly)
form Solid
color White to Off-White
Stability Hygroscopic
FDA UNII EOS72165S7
NCI Drug Dictionary fesoterodine fumarate

Pharmacokinetic data

Protein binding 50 (metabolite)
Excreted unchanged in urine 70 (as metabolites)
Volume of distribution 169 Litres
Biological half-life 7 / -

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS07,GHS08
Signal word  Warning
Hazard statements  H302-H361-H402-H319
Precautionary statements  P201-P202-P281-P308+P313-P405-P501-P264-P280-P305+P351+P338-P337+P313P-P264-P270-P301+P312-P330-P501
NFPA 704
0
2 0

Fesoterodinefumarate price More Price(32)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 23777 Fesoterodine (fumarate) ≥98% 286930-03-8 1mg $29 2024-03-01 Buy
Cayman Chemical 23777 Fesoterodine (fumarate) ≥98% 286930-03-8 5mg $72 2024-03-01 Buy
Cayman Chemical 23777 Fesoterodine (fumarate) ≥98% 286930-03-8 10mg $99 2024-03-01 Buy
TRC F321300 (R)-FesoterodineFumarate 286930-03-8 25mg $145 2021-12-16 Buy
TRC F321300 (R)-FesoterodineFumarate 286930-03-8 50mg $275 2021-12-16 Buy
Product number Packaging Price Buy
23777 1mg $29 Buy
23777 5mg $72 Buy
23777 10mg $99 Buy
F321300 25mg $145 Buy
F321300 50mg $275 Buy

Fesoterodinefumarate Chemical Properties,Uses,Production

Description

Fesoterodine fumarate is a new drug for the treatment of overactive bladder syndrome developed by Pfizer, which was approved by the US FDA in October 2008. Fesoterodine fumarate is a prodrug, which is rapidly hydrolyzed in blood after oral administration to 5-hydroxymethyl tolterodine (5-HMT), which is also the active metabolite of tolterodine.

Biological activity

Fesoterodine Fumarate (SPM 907) is a prodrug of the muscarinic receptor antagonist 5-hydroxymethyl tolterodine, used to treat overactive bladder.

Side effects

The most common side effects was dry mouth, which was observed in the placebo group, the product 4 in the Phase II and Phase III clinical trials (a total of 2 859 patients, 2 288 taking this product for 8 to 12 weeks). The incidences of dry mouth at mg/d and 8 mg/d were 7%, 19%, and 35%, respectively, and the incidences of drug discontinuation due to dry mouth were 0.4%, 0.4%, and 0.8%, respectively. The second most common adverse reaction was constipation. The incidence of constipation in the placebo group and the 4 mg/d and 8 mg/d groups of this product was 2%, 4% and 6%, respectively. Other reported adverse events included loss of appetite, nausea, epigastric pain, urinary tract infection, upper respiratory tract infection, dry eyes, dysuria, urinary retention, cough, peripheral edema, back pain, insomnia, abnormal liver function, and rash.

Chemical Properties

White Solid

Uses

(R)-Fesoterodine Fumarate is a muscarinic receptor antagonist for the treatment of Lower Urininary Tract Symptoms (LUTS). It is very similar to Tolterodine (T535800).

Uses

Fesoterodine fumarate (Toviaz) is an antimuscarinic agent and is rapidly de-esterified to its active metabolite 5-hydroxymethyl tolterodine that is a muscarinic receptor antagonist. Fesoterodine fumarate (Toviaz) is used to treat the symptoms of overactiv

Clinical Use

Antimuscarinic:
Symptomatic treatment of urinary incontinence, frequency or urgency

Drug interactions

Potentially hazardous interactions with other drugs
 Anti-arrhythmics: increased risk of antimuscarinic side effects with disopyramide.
 Antifungals: dose reduction advised with itraconazole and ketoconazole.
 Antivirals: dose reduction advised with atazanavir, indinavir, ritonavir and saquinavir.
 Induction of CYP3A4 may lead to subtherapeutic plasma levels. Concomitant use with CYP3A4 inducers (e.g. carbamazepine, rifampicin, phenobarbital, phenytoin, St John's Wort) is not recommended.
 Co-administration of a potent CYP2D6 inhibitor may result in increased exposure and adverse events. A dose reduction to 4 mg may be needed' 

Metabolism

Rapidly and extensively hydrolysed to its active metabolite. The active metabolite is further metabolised in the liver to its carboxy, carboxy-N-desisopropyl, and N-desisopropyl metabolites via two major pathways involving CYP2D6 and CYP3A4. None of these metabolites contribute significantly to the antimuscarinic activity of fesoterodine. Approximately 70% of an oral dose of fesoterodine is recovered in the urine as metabolites, and a smaller amount in the faeces.

Fesoterodinefumarate Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 237)Suppliers
Supplier Tel Email Country ProdList Advantage
Henan Bao Enluo International TradeCo.,LTD
+86-17331933971 +86-17331933971 deasea125996@gmail.com China 2472 58
Henan Fengda Chemical Co., Ltd
+86-371-86557731 +86-13613820652 info@fdachem.com China 20283 58
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
+86-18600796368 +86-18600796368 sales@sjar-tech.com China 474 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21634 55
career henan chemical co
+86-0371-86658258 +8613203830695 sales@coreychem.com China 29880 58
Shaanxi Yikanglong Biotechnology Co., Ltd.
17791478691 yklbiotech@163.com CHINA 296 58
Biochempartner
0086-13720134139 candy@biochempartner.com CHINA 965 58
Hangzhou Cyanochem Co., Ltd.
+86 17788583750 sales@cyanochem.com CHINA 281 58
Hubei Jusheng Technology Co.,Ltd.
18871490254 linda@hubeijusheng.com CHINA 28172 58
BOC Sciences
+1-631-485-4226 inquiry@bocsci.com United States 19553 58

View Lastest Price from Fesoterodinefumarate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Fesoterodine Fumarate pictures 2024-12-25 Fesoterodine Fumarate
286930-03-8
US $0.00 / g 1g More Than 99% 50kg/Month BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
Fesoterodinefumarate pictures 2024-12-13 Fesoterodinefumarate
286930-03-8
US $0.00 / g 1g 99%~101% 10kg/month WUHAN FORTUNA CHEMICAL CO., LTD
Fesoterodine fumarate pictures 2024-11-19 Fesoterodine fumarate
286930-03-8
US $47.00-113.00 / mg 98.55% 10g TargetMol Chemicals Inc.

Fesoterodinefumarate Spectrum

(R)-2-(3-(diisopropylamino)-1-phenylpropyl)-4-(hydroxymethyl)phenyl isobutyrate fumarate (R)-Fesoterodine fumarate 2-[(1R)-3-[Bis(1-methylethyl)amino]-1-phenylpropyl]-4-(hydroxymethyl)phenyl 2-methylpropanoate fumarate (R)-2-(3-(Diisopropylamino)-1-phenylpropyl)-4-methoxyphenyl isobutyrate fumarate Fesoterodine maleate 2-[(1R)-3-[Bis(1-methylethyl)amino]-1-phenylpropyl]-4-(hydroxymethyl)phenyl 2-methylpropanoate fumarate Propanoic acid, 2-methyl-, 2-((1R)-3-(bis(1-methylethyl)amino)-1-phenylpropyl)-4-(hydroxymethyl)phenyl ester, (2E)-2-butenedioate (1:1) (salt) Spm 8272 Toviaz Unii-eos72165S7 Fesoterodinefumarate (R)-Fesoterodine Fumarate 2-Methylpropanoic Acid 2-[(1R)-3-[Bis(1-methylethyl)amino]-1-phenylpropyl]-4-(hydroxymethyl)phenyl Ester (2E)-2-Butenedioate SMP 8272 SPM 907 FESOTERODINE MALEATE INTERMEDIATES Fesoterodine fuMarate (Toviaz) 2-((1R)-3-(Diisopropylamino)-1-phenylpropyl)-4(hydroxymethyl)phenyl isobutyrate Fesoterodine fuMarate salt PF-00695838 fumarate Fesoterodine-fumarlate-d7 [2-[(1R)-3-(Di(propan-2-yl)amino)-1-phenylpropyl]-4-(hydroxymethyl)phenyl] 2-methylpropanoate fumarate Fesoterodine maleate (Toviaz) CS-102 CS-244 Fesoterodinefumarate USP/EP/BP Fesoterodine fumarateQ: What is Fesoterodine fumarate Q: What is the CAS Number of Fesoterodine fumarate Q: What is the storage condition of Fesoterodine fumarate TIANFUCHEM--Fesoterodinefumarate 2-[(1R)-3-(diisopropylamino)-1-phenyl-propyl]-4-(hydroxymethyl)phenyl] 2-methylpropanoate 286930-03-8 C26H37NO3C4H4O4 C30H41NO7 Toviaz Amines Aromatics Intermediates & Fine Chemicals Pharmaceuticals Aromatics Compounds