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IM-156 (acetate)

CAS No.
2043654-54-0
Chemical Name:
IM-156 (acetate)
Synonyms
IM-156 (acetate);IM156 (acetate),IM 156 (acetate)
CBNumber:
CB511075249
Molecular Formula:
C15H20F3N5O3
Molecular Weight:
375.35
MDL Number:
MOL File:
2043654-54-0.mol
Last updated:2024-10-23 13:36:13

IM-156 (acetate) Properties

storage temp. -20°C
solubility DMF: 1 mg/ml,DMSO: 1 mg/ml,Ethanol: 1 mg/ml
form A solid

IM-156 (acetate) Chemical Properties,Uses,Production

Biological Activity

IM-156 is an inhibitor of mitochondrial complex I, also known as NADH dehydrogenase (IC50 = 2.2 μM) and an activator of AMP-activated protein kinase α (AMPKα).1,2 It reduces the oxygen consumption rate (OCR; IC50 = 3.3 μM) and decreases mitochondrial ATP production in Eμ-Myc mouse lymphoma cells.1 IM-156 (10, 30, and 50 μM) increases AMPKα activity in primary rat peritoneal mesothelial cells and protects against chlorhexidine-induced peritoneal fibrosis in rats when administered at a dose of 1 mg/kg.2 It reduces tumor growth in an AT-84 murine oral cancer model and decreases age-related decline in novel object recognition, spatial working, and contextual memory in mice.3,4

References

1.Izreig, S., Gariepy, A., Kaymak, I., et al.Repression of LKB1 by miR-17~92 sensitizes MYC-dependent lymphoma to biguanide treatmentCell Rep. Med.1(2)100014(2020) 2.Ju, K.D., Kim, H.J., Tsogbadrakh, B., et al.HL156A, a novel AMP-activated protein kinase activator, is protective against peritoneal fibrosis in an in vivo and in vitro model of peritoneal fibrosisAm. J. Physiol. Renal. Physiol.310(5)F342-F350(2016) 3.Lam, T.G., Jeong, Y.S., Kim, S.-A., et al.New metformin derivative HL156A prevents oral cancer progression by inhibiting the insulin-like growth factor/AKT/mammalian target of rapamycin pathwaysCancer Sci.109(3)699-709(2018) 4.Bang, E., Lee, B., Park, J.-O., et al.The improving effect of HL271, a chemical derivative of metformin, a popular drug for type II diabetes mellitus, on aging-induced cognitive declineExp. Neurobiol.27(1)45-56(2018)

IM-156 (acetate) Preparation Products And Raw materials

Raw materials

Preparation Products

IM-156 (acetate) Suppliers

Global( 5)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32161 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24644 58
Shanghai Yiyan Biotechnology Co. , Ltd. 021-69985186 13611928337 3427709316@qq.com China 7979 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11974 58

View Lastest Price from IM-156 (acetate) manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
IM-156 acetate pictures 2024-10-24 IM-156 acetate
2043654-54-0
US $50.00 / mg 90% 10g TargetMol Chemicals Inc.
IM-156 (acetate) IM156 (acetate),IM 156 (acetate) 2043654-54-0