ChemicalBook >> CAS DataBase List >>(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol
(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol
![(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol Structure](CAS/GIF/127852-28-2.gif)
- CAS No.
- 127852-28-2
- Chemical Name:
- (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol
- Synonyms
- C1oHgF6O;R-MBT-PEL;(R)-1-[3,5-Bis(trifL;Aprepitant Impurity 49;Phenol,5-iodo-4-methyl-;Rolapitant Intermediate 3;Fosaprepitant Impurity 25;Thiazole,2-bromo-9-methyl-;(R)-1-[3,5- Bis(trifluoromethyl)phenyl]et;(R)-BIS-3,5-TRIFLUOROMETHYL-1-PHENYLETHANOL
- CBNumber:
- CB5113482
- Molecular Formula:
- C10H8F6O
- Molecular Weight:
- 258.16
- MDL Number:
- MFCD03093010
- MOL File:
- 127852-28-2.mol
- MSDS File:
- SDS
Last updated:2024-12-09 16:05:57
| Melting point | 53-58℃ |
|---|---|
| Boiling point | 175.8±35.0 °C(Predicted) |
| Density | 1.376±0.06 g/cm3(Predicted) |
| storage temp. | -20°C Freezer |
| solubility | Acetonitrile (Slightly), Chloroform (Slightly) |
| pka | 13.99±0.20(Predicted) |
| form | Powder |
| color | White |
| optical activity | [α]/D +27±1°, c = 1 in acetonitrile |
| λmax | 272nm(MeOH)(lit.) |
| InChIKey | MMSCIQKQJVBPIR-RXMQYKEDSA-N |
| CAS DataBase Reference | 127852-28-2(CAS DataBase Reference) |
| FDA UNII | 26EP435WQ9 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H302-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313 | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 36/37/38-52/53-22 | |||||||||
| Safety Statements | 26-36/37/39-61 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Irritant | |||||||||
| HS Code | 29062990 | |||||||||
| NFPA 704 |
|
(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol price More Price(39)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 49554 | (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol ≥98.0% (GC) | 127852-28-2 | 5g | $72 | 2023-06-20 | Buy |
| Sigma-Aldrich | 49554 | (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol ≥98.0% (GC) | 127852-28-2 | 25g | $216 | 2023-06-20 | Buy |
| TCI Chemical | B4131 | (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol >98.0%(GC) | 127852-28-2 | 5g | $66 | 2024-03-01 | Buy |
| TCI Chemical | B4131 | (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol >98.0%(GC) | 127852-28-2 | 25g | $213 | 2024-03-01 | Buy |
| Alfa Aesar | H60893 | (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol, 98% | 127852-28-2 | 5g | $73.08 | 2023-01-06 | Buy |
(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol Chemical Properties,Uses,Production
Uses
(R)-[3,5-bis (trifluoromethyl) phenyl] ethanol is an important chiral intermediate for the synthesis of novel chemotherapeutic and antiemetic drugs NK-1 receptor antagonists. Antidepressants have good potential efficacy in treating a range of central and peripheral nervous system depressions.
Preparation
At present, the methods for preparing optically pure (R)-[3,5-bis (trifluoromethyl) phenyl] ethanol include chemical methods and biological methods. Chemical synthesis requires the use of expensive transition metal Ru and other chemical catalysts, complicated steps, harsh reaction conditions, high energy consumption, large pollution, and low yield. Biological law is the use of free enzymes or whole cells for catalytic preparation. It has the characteristics of mild reaction conditions, high catalytic efficiency, and strong specificity.
Chemical Properties
White fine crystalline powder
Uses
(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol is an intermediate in the synthesis of Aprepitant (A729800), a novel selective neurokinin-1 (NK-1) receptor antagonist. In vitro studies using human liver microsomes indicate that Aprepitant is metabolised primarily by CYP3A4 with minor metabolism by CYP1A2 and CYP2C19, and no metabolism by CYP2D6, CYP2C9, or CYP2E1. Antiemetic.
General Description
(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol is a key intermediate for the synthesis of aprepitant, a potent human neurokinin-1 (NK-1) receptor.
(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 435)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Yingrui Biopharma Co.,Ltd | 21-33585366 | export01@shyrchem.com | CHINA | 1319 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | sales1@chuanghaibio.com | China | 5889 | 58 |
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 +86-17331933971 | deasea125996@gmail.com | China | 2472 | 58 |
| Hangzhou ICH Biofarm Co., Ltd | +86-0571-28186870; +undefined8613073685410 | sales@ichemie.com | China | 1001 | 58 |
| Anhui Ruihan Technology Co., Ltd | +8617756083858 | daisy@anhuiruihan.com | China | 973 | 58 |
| Hebei Zhuanglai Chemical Trading Co Ltd | +86-16264648883 +86-16264648883 | niki@zlchemi.com | China | 2691 | 58 |
| Frapp's ChemicalNFTZ Co., Ltd. | +86 (576) 8169-6106 | sales@frappschem.com | China | 880 | 50 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29791 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 18751 | 58 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1803 | 55 |
Related articles
- What is (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol?
- (R)-[3,5-bis (trifluoromethyl) phenyl] ethanol is an important chiral intermediate for the synthesis of novel chemotherapeutic....
- Feb 24，2020
View Lastest Price from (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
![(R)-1-[3,5-Bis(trilfuoromethyl)phenyl]ethanol pictures](/ProductImageEN1/2024-12/Small/60fc8777-805a-46dd-be71-2fda94cb4e65.jpg) |
2024-12-20 | (R)-1-[3,5-Bis(trilfuoromethyl)phenyl]ethanol
127852-28-2
|
US $10.00 / kg | 1kg | 99% | 20 ton | Hebei Zhuanglai Chemical Trading Co Ltd | |
![(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol pictures](/ProductImageEN/2023-03/Small/1aa0ff27-52e1-4406-a02f-9b48f6f003ff.png) |
2024-12-12 | (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol
127852-28-2
|
US $300.00-250.00 / kg | 100kg | 99.99% | 100Tons | Hebei Dangtong Import and export Co LTD | |
![(R)-1-[3,5-Bis(trilfuoromethyl)phenyl]ethanol pictures](/ProductImageEN/2023-05/Small/ba7c4da0-d4fe-4631-848d-a2aa68a29707.jpg) |
2024-10-11 | (R)-1-[3,5-Bis(trilfuoromethyl)phenyl]ethanol
127852-28-2
|
US $5.00-2.00 / KG | 1KG | 99% | 10000kg | Hebei Chuanghai Biotechnology Co,.LTD |
-
- (R)-1-[3,5-Bis(trilfuoromethyl)phenyl]ethanol
127852-28-2
- US $10.00 / kg
- 99%
- Hebei Zhuanglai Chemical Trading Co Ltd
-
- (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol
127852-28-2
- US $300.00-250.00 / kg
- 99.99%
- Hebei Dangtong Import and export Co LTD
-
- (R)-1-[3,5-Bis(trilfuoromethyl)phenyl]ethanol
127852-28-2
- US $5.00-2.00 / KG
- 99%
- Hebei Chuanghai Biotechnology Co,.LTD
127852-28-2((R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol)Related Search:
(R)-BIS-3,5-TRIFLUOROMETHYL-1-PHENYLETHANOL
(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol,99%e.e.
(R)-1-[3,5-BIS(TRIFLUORO-METHYL)-PHENYL]ETHANOL 98%
(1R)-1-[3,6-BIS(TRIFLUOROMETHYL)PHENYL]ETHANOL
R-MBT-PEL
(R)-1-(3,5-BIS(TRIFLUOROMETHYL)PHENYL)ETHAN-1-OL
(R)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHANOL
(R)-1-[BIS-3,5-(TRIFLUOROMETHYL)PHENYL]ETHANOL
Benzenemethanol, a-methyl-3,5-bis(trifluoromethyl)-, (aR)-
(1R)-(+)-1-[3,5-Bis(trifluoromethyl)phenyl]ethan-1-ol
(R)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethanol >=98.0% (GC)
Benzenemethanol, .alpha.-methyl-3,5-bis(trifluoromethyl)-, (.alpha.R)-
(R)-1-[3,5-Bis(trifluoromethyl) phenyl]ethanol,Aprepitant intermediate
Rolapitant Intermediate 3
(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol127852-28-2
Fosaprepitant Impurity 25
Aprepitant Impurity 49
(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol
（Aprepitant）
(R)-1-[3,5-Bis(trilfuoromethyl)phenyl]ethanol
(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol >
(R)-1-[3,5-di (trifluoromethyl) phenyl] ethanol
(R)-1-[3,5-Bis(trifL
Benzenemethanol, α-methyl-3,5-bis(trifluoromethyl)-, (αR)-
(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethyl Alcohol
(R)-3,5-Bis(trifluoromethyl)-alpha-methylbenzyl Alcohol
Aprepitant intermediates，(R)-1-[3,5- Bis(trifluoromethyl)phenyl]ethanol
?-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol
(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol, 98%,
(R)-1-[3,5-Bis(trifluoromethyl)phenyi]ethanol
Thiazole,2-bromo-9-methyl-
Phenol,5-iodo-4-methyl-
Benzenemethanol,α-methyl-3,5-bis(trifluoromethyl)-,(αR)-
(S)-1-(3,5-Bi(trifluoromethyl)phenyl)ethan-1-ol
(αR)-α-Methyl-3,5-bis(trifluoromethyl)benzenemethanol
(alphaR)-alpha-Methyl-3,5-bis(trifluoromethyl)-benzenemethanol
C1oHgF6O
(R)-l-(3,5-bis(trifluorom ethyl)pheny l)ethan-1 -ol
(R)-1-[3,5- Bis(trifluoromethyl)phenyl]et
127852-28-2
C10H8F7O
C10H8OF6
API intermediates
Alcohols, Hydroxy Esters and Derivatives
Chiral Compounds
127852-28-2