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YAP/TAZinhibitor2

YAP/TAZinhibitor2 Structure
YAP/TAZinhibitor2 structure
CAS No.
2762617-31-0
Chemical Name:
YAP/TAZinhibitor2
Synonyms
YAP/TAZinhibitor2;YAP/TAZ inhibitor-2;YAP/TAZ inhibitor-2u00A0;YAP/TAZ inhibitor-2u00A0, 10 mM in DMSO;2-Fluoro-1-(3-(3-(4-(trifluoromethyl)phenyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)azetidin-1-yl)prop-2-en-1-one;2-Propen-1-one, 2-fluoro-1-[3-[3-[4-(trifluoromethyl)phenyl]-1H-pyrazolo[3,4-b]pyridin-1-yl]-1-azetidinyl]-
CBNumber:
CB511631551
Molecular Formula:
C19H14F4N4O
Molecular Weight:
390.33
MDL Number:
MOL File:
2762617-31-0.mol
Last updated:2025-04-17 18:22:24
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YAP/TAZinhibitor2 Properties

Boiling point 559.9±50.0 °C(Predicted)
Density 1.45±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : 100 mg/mL (256.19 mM; Need ultrasonic)
pka 2.50±0.30(Predicted)
form Solid
color Light yellow to yellow

YAP/TAZinhibitor2 Chemical Properties,Uses,Production

Uses

YAP/TAZ inhibitor-2 is a potent and orally active TEAD-YAP/TAZ inhibitor with an EC50 value of 3 nM. YAP/TAZ inhibitor-2 shows anti-proliferative activity. YAP/TAZ inhibitor-2 shows antitumor activity[1].

Biological Activity

YAP/TAZ inhibitor-2 is a potent and orally active TEAD-YAP/TAZ inhibitor with an EC50 value of 3 nM. YAP/TAZ inhibitor-2 shows anti-proliferative activity. YAP/TAZ inhibitor-2 shows antitumor activity[1]. YAP/TAZ inhibitor-2 (compound 5) (0-20000 nM; 24 h) shows antiproliferative activity with an IC50 value of 5.33 nM in NCI-H226 cells[1]. YAP/TAZ inhibitor-2 (0.5, 2, 5, 50 mg/kg; p.o.; daily for 28 days) shows anti-tumor activity with no significant body weight loss during the treatment in BALB/c nude mice (NCI-H226 xenograft model)[1].

in vivo

YAP/TAZ inhibitor-2 (0.5, 2, 5, 50 mg/kg; p.o.; daily for 28 days) shows anti-tumor activity with no significant body weight loss during the treatment in BALB/c nude mice (NCI-H226 xenograft model)[1].

IC 50

YAP/TAZ-TEAD

References

[1]. Xu, xiaofeng, et al. Bicyclic compounds, compositions and use thereof. WO2022037568A1.

YAP/TAZinhibitor2 Preparation Products And Raw materials

Raw materials

Preparation Products

YAP/TAZinhibitor2 Suppliers

Global( 14)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32222 58
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266 China 4613 55
Shanghai SuperLan Chemcial Technique Centre 021-2022843681 15618226720 lucy@atkchemical.com China 10123 58
Chuzhou KeMail Chemical Technology Co., Ltd 0550-5196001 15000891977 wj520wjxby@126.com China 1928 55
Shenzhen Polymeri Biochemical Technology Co., Ltd. +86-400-002-6226 +86-13028896684; sales@rrkchem.com China 57422 58
Bide Pharmatech Ltd. 400-1647117 13681763483 product02@bidepharm.com China 62072 58
Chengdu PEIP Pharmaceutical Technology Co., LTD. 028-61715638 18011352545 1242335275@qq.com China 392 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24718 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11973 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
TargetMol Chemicals Inc. 		58
Shanghai Lollane Biological Technology Co.,Ltd. 55
Shanghai SuperLan Chemcial Technique Centre 58
Chuzhou KeMail Chemical Technology Co., Ltd 55
Shenzhen Polymeri Biochemical Technology Co., Ltd. 58
Bide Pharmatech Ltd. 58
Chengdu PEIP Pharmaceutical Technology Co., LTD. 58
TargetMol Chemicals Inc. 58
Shanghai Yifei Biotechnology Co. , Ltd. 58

View Lastest Price from YAP/TAZinhibitor2 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
YAP/TAZ inhibitor-2 pictures 2025-04-28 YAP/TAZ inhibitor-2
2762617-31-0
 US $84.00-197.00 / mg 98.84% 10g TargetMol Chemicals Inc.
YAP/TAZ inhibitor-2 YAP/TAZinhibitor2 2-Propen-1-one, 2-fluoro-1-[3-[3-[4-(trifluoromethyl)phenyl]-1H-pyrazolo[3,4-b]pyridin-1-yl]-1-azetidinyl]- YAP/TAZ inhibitor-2u00A0 2-Fluoro-1-(3-(3-(4-(trifluoromethyl)phenyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)azetidin-1-yl)prop-2-en-1-one YAP/TAZ inhibitor-2u00A0, 10 mM in DMSO 2762617-31-0