Chloropretadalafil
- CAS No.
- 171489-59-1
- Chemical Name:
- Chloropretadalafil
- Synonyms
- (6R,12aR)-methyl1,2,3,4-tetrahydro-2-chloroacetyl-1-(3,4-methylenedioxyphenyl)-9H-pyrido[3,4-b]indole-3-carboxylate;(1R,3R)-1-(1,3-Benzodioxol-5-yl)-2-(chloroacetyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-B]indole-3-carboxylic acid methyl ester;(1R,3R)-1-(1,3-Benzodioxol-5-yl)-2-(chloroacetyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylicacidmethyeste;Tadanafil P-1;Methyl (1R,3R;Chloropretadalafil;adalafil impurity 1;Tadaafil Intermediate;B]indole-3-carboxylate;Tadalafil intermediate 2
- CBNumber:
- CB5116504
- Molecular Formula:
- C22H19ClN2O5
- Molecular Weight:
- 426.85
- MDL Number:
- MFCD04973633
- MOL File:
- 171489-59-1.mol
- MSDS File:
- SDS
Melting point | 230-232℃ |
---|---|
Boiling point | 627.5±55.0 °C(Predicted) |
Density | 1.445 |
storage temp. | Inert atmosphere,2-8°C |
solubility | Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly) |
pka | 16.25±0.60(Predicted) |
form | Solid |
color | White to Pale Orange |
InChI | InChI=1S/C22H19ClN2O5/c1-28-22(27)16-9-14-13-4-2-3-5-15(13)24-20(14)21(25(16)19(26)10-23)12-6-7-17-18(8-12)30-11-29-17/h2-8,16,21,24H,9-11H2,1H3/t16-,21-/m1/s1 |
InChIKey | JUKHNCNDFOAFLT-IIBYNOLFSA-N |
SMILES | N1C2=C(C=CC=C2)C2C[C@H](C(OC)=O)N(C(CCl)=O)[C@H](C3=CC=C4OCOC4=C3)C1=2 |
FDA UNII | 1P8ITA120M |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H335-H315-H319 |
Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P |
Chloropretadalafil price More Price(19)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
TRC | M330125 | (1R,3R)-Methyl-1,2,3,4-tetrahydro-2-chloroacetyl-1-(3,4-methylenedioxyphenyl)-9H-pyrido[3,4-b]indole-3-carboxylate(Chloropretadalafil) | 171489-59-1 | 2g | $185 | 2021-12-16 | Buy |
AK Scientific | Z2024 | (1R,3R)-1-Benzo[1,3]dioxol-5-yl-2-(2-chloroethanoyl)2,3,4,9-tetrahydro-1H-b-carboline-3-carboxylicacidmethylester | 171489-59-1 | 5g | $109 | 2021-12-16 | Buy |
AK Scientific | Z2024 | (1R,3R)-1-Benzo[1,3]dioxol-5-yl-2-(2-chloroethanoyl)2,3,4,9-tetrahydro-1H-b-carboline-3-carboxylicacidmethylester | 171489-59-1 | 10g | $149 | 2021-12-16 | Buy |
American Custom Chemicals Corporation | API0028594 | CHLOROPRETADALAFIL 95.00% | 171489-59-1 | 5MG | $459.06 | 2021-12-16 | Buy |
Matrix Scientific | 095485 | (1R,3R)-Methyl 1-(benzo[d][1,3]dioxol-5-yl)-2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate 95+% | 171489-59-1 | 1g | $16 | 2021-12-16 | Buy |
Chloropretadalafil Chemical Properties,Uses,Production
Description
Chloropretadalafil is a key synthetic intermediate of tadalafil which is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5).
Chemical Properties
White Solid
Uses
(1R,3R)-1-(1,3-Benzodioxol-5-yl)-2-(chloroacetyl)-2,3,4,9- tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic is used as an intermediate in the synthesis of Tadafil, which is used for the treatment of erectile dysfunction.
References
[1] ALAIN DAUGAN. The Discovery of Tadalafil: A Novel and Highly Selective PDE5 Inhibitor. 2: 2,3,6,7,12,12a-hexahydropyrazino[1‘,2‘:1,6]pyrido[3,4-b]indole-1,4-dione Analogues[J]. Journal of Medicinal Chemistry, 2003. DOI:10.1021/jm0300577.
[2] SHI X X, LIU S, XU W Z, et al. Highly stereoselective Pictet–Spengler reaction of d-tryptophan methyl ester with piperonal: convenient syntheses of Cialis (Tadalafil), 12a-epi-Cialis, and their deuterated analogues[J]. Tetrahedron-asymmetry, 2008, 19: 435-442. DOI:10.1016/J.TETASY.2007.12.017.
[3] ZHANG Y, HE Q, DING H, et al. IMPROVED SYNTHESIS OF TADALAFIL[J]. Organic Preparations and Procedures International, 2005, 37: 102-199. DOI:10.1080/00304940509355408.
![79-04-9](/CAS/GIF/79-04-9.gif)
![171596-41-1](/CAS/GIF/171596-41-1.gif)
![171489-59-1](/CAS/GIF/171489-59-1.gif)
Chloropretadalafil Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Zhengzhou Lingzhiyue Technology Co., Ltd | +86-0371-55074660 +86-13783527580 | Lingzhiyue@aliyun.com | China | 3152 | 58 |
Shandong Luning Pharmaceutical Co., Ltd. | +86-0546-6491488 +86-13305469775 | sale@lntzkg.com | China | 40 | 58 |
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd | +86-19164747840 +86-13119157289 | 13119157289@163.com | China | 2972 | 58 |
Hangzhou ICH Biofarm Co., Ltd | +86-0571-28186870; +undefined8613073685410 | sales@ichemie.com | China | 988 | 58 |
Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 | Mandy@hangyubiotech.com | China | 10977 | 58 |
Anhui Ruihan Technology Co., Ltd | +8617756083858 | daisy@anhuiruihan.com | China | 994 | 58 |
Apeloa production Co.,Limited | +8619933239880 | admin@apcl.com.cn | China | 853 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29798 | 60 |
Taizhou Tianhong Biochemistry Technology Co., Ltd. | 0523-86132544 | sales@thbiochem.com | CHINA | 305 | 60 |
Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
View Lastest Price from Chloropretadalafil manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
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2024-08-23 | Chloropretadalafil
171489-59-1
|
US $1.00 / g | 1g | 98% | 1000 | Apeloa production Co.,Limited | |
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2024-08-06 | (1R,3R)-methyl-1,2,3,4-tetrahydro-2-chloroacetyl-1-(3,4-methylenedioxyphenyl)-9H-pyrido[3,4-B]indole-3-carboxylate
171489-59-1
|
US $171.00 / KG | 1KG | 99% | 6000KG | Shandong Luning Pharmaceutical Co., Ltd. | |
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2024-05-10 | Chloropretadalafil
171489-59-1
|
US $45.00-450.00 / KG | 1KG | 0.99 | 20 tons | Zibo Hangyu Biotechnology Development Co., Ltd |
-
- Chloropretadalafil
171489-59-1
- US $1.00 / g
- 98%
- Apeloa production Co.,Limited
-
- (1R,3R)-methyl-1,2,3,4-tetrahydro-2-chloroacetyl-1-(3,4-methylenedioxyphenyl)-9H-pyrido[3,4-B]indole-3-carboxylate
171489-59-1
- US $171.00 / KG
- 99%
- Shandong Luning Pharmaceutical Co., Ltd.
-
- Chloropretadalafil
171489-59-1
- US $45.00-450.00 / KG
- 0.99
- Zibo Hangyu Biotechnology Development Co., Ltd
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