ChemicalBook >> CAS DataBase List >>(4S,7R,8S,9S,13Z,16S)-4,8-Bis-{[tert-butyl(dimethyl)silyl]oxy}-5,5,7,9,13-pentamethyl-16-[(E)-1-methyl-2-(2-methyl-1,3-thiazol-4-yl)ethenyl]oxocyclohexadec-13-ene-2,6-dione
(4S,7R,8S,9S,13Z,16S)-4,8-Bis-{[tert-butyl(dimethyl)silyl]oxy}-5,5,7,9,13-pentamethyl-16-[(E)-1-methyl-2-(2-methyl-1,3-thiazol-4-yl)ethenyl]oxocyclohexadec-13-ene-2,6-dione
- CAS No.
- 189453-35-8
- Chemical Name:
- (4S,7R,8S,9S,13Z,16S)-4,8-Bis-{[tert-butyl(dimethyl)silyl]oxy}-5,5,7,9,13-pentamethyl-16-[(E)-1-methyl-2-(2-methyl-1,3-thiazol-4-yl)ethenyl]oxocyclohexadec-13-ene-2,6-dione
- Synonyms
- Paclitaxel Impurity 73;[4S-[4R*,7S*,8R*,9R*,13Z,16R*(E)]]-4,8-Bis[[(1,1-diMethylethyl)diMethylsilyl]oxy]-;(4S,7R,8S,9S,13Z,16S)-4,8-Bis-{[Tert-Butyl(Dimethyl)Silyl]Oxy}-5,5,7,9,13-Pentamethyl-16-[(E)-1-Methyl-2-(2-Methyl-1,3-Thiazol-4-Yl)Ethenyl]Oxcyclohexadec-13-Ene-2,6-Dione;(4S,7R,8S,9S,13Z,16S)-4,8-Bis-{[tert-butyl(dimethyl)silyl]oxy}-5,5,7,9,13-pentamethyl-16-[(E)-1-methyl-2-(2-methyl-1,3-thiazol-4-yl)ethenyl]oxocyclohexadec-13-ene-2,6-dione;Oxacyclohexadec-13-ene-2,6-dione, 4,8-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-5,5,7,9,13-pentamethyl-16-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-, (4S,7R,8S,9S,13Z,16S)-
- CBNumber:
- CB51175348
- Molecular Formula:
- C39H69NO5SSi2
- Molecular Weight:
- 720.2
- MDL Number:
- MOL File:
- 189453-35-8.mol
- MSDS File:
- SDS
Last updated:2023-06-02 08:28:42
(4S,7R,8S,9S,13Z,16S)-4,8-Bis-{[tert-butyl(dimethyl)silyl]oxy}-5,5,7,9,13-pentamethyl-16-[(E)-1-methyl-2-(2-methyl-1,3-thiazol-4-yl)ethenyl]oxocyclohexadec-13-ene-2,6-dione Properties
Boiling point | 698.1±55.0 °C(Predicted) |
---|---|
Density | 1.01±0.1 g/cm3(Predicted) |
solubility | Chloroform, Dichloromethane, Ethanol, Ethyl Acetate, Methanol, Toluene |
form | Foam |
pka | 2.56±0.10(Predicted) |
color | White |
(4S,7R,8S,9S,13Z,16S)-4,8-Bis-{[tert-butyl(dimethyl)silyl]oxy}-5,5,7,9,13-pentamethyl-16-[(E)-1-methyl-2-(2-methyl-1,3-thiazol-4-yl)ethenyl]oxocyclohexadec-13-ene-2,6-dione price
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
TRC | B415780 | (4S,7R,8S,9S,13Z,16S)-4,8-Bis-{[tert-butyl(dimethyl)silyl]oxy}-5,5,7,9,13-pentamethyl-16-[(E)-1-methyl-2-(2-methyl-1,3-thiazol-4-yl)ethenyl]oxocyclohexadec-13-ene-2,6-dione | 189453-35-8 | 1mg | $1100 | 2021-12-16 | Buy |
Biosynth Carbosynth | FB18800 | (4S,7R,8S,9S,13Z,16S)-4,8-Bis-{[tert-butyl(dimethyl)silyl]oxy}-5,5,7,9,13-pentamethyl-16-[(E)-1-methyl-2-(2-methyl-1,3-thiazol-4-yl)ethenyl]oxocyclohexadec-13-ene-2,6-dione | 189453-35-8 | 1mg | $1365 | 2021-12-16 | Buy |
American Custom Chemicals Corporation | ORS0001290 | (4S,7R,8S,9S,13Z,16S)-4,8-BIS-((TERT-BUTYL(DIMETHYL)SILYL)OXY)-5,5,7,9,13-PENTAMETHYL-16-((E)-1-METHYL-2-(2-METHYL-1,3-THIAZOL-4-YL)ETHENYL)OXOCYCLOHEXADEC-13-ENE-2,6-DIONE 95.00% | 189453-35-8 | 1MG | $1732.5 | 2021-12-16 | Buy |
American Custom Chemicals Corporation | ORS0001290 | (4S,7R,8S,9S,13Z,16S)-4,8-BIS-((TERT-BUTYL(DIMETHYL)SILYL)OXY)-5,5,7,9,13-PENTAMETHYL-16-((E)-1-METHYL-2-(2-METHYL-1,3-THIAZOL-4-YL)ETHENYL)OXOCYCLOHEXADEC-13-ENE-2,6-DIONE 95.00% | 189453-35-8 | 0.1MG | $279 | 2021-12-16 | Buy |
(4S,7R,8S,9S,13Z,16S)-4,8-Bis-{[tert-butyl(dimethyl)silyl]oxy}-5,5,7,9,13-pentamethyl-16-[(E)-1-methyl-2-(2-methyl-1,3-thiazol-4-yl)ethenyl]oxocyclohexadec-13-ene-2,6-dione Chemical Properties,Uses,Production
Chemical Properties
White Foam
Uses
An intermediate in the synthesis of Epothilones. Epothilones are polyketide natural products that inhibit cancer cells by a mechanism similar to paclitaxel, and also are effective against paclitaxel-resistant tumours. Epothilone D is in phase I clinical testing of in patients with advanced solid tumours. Epothilone D is a cytotoxic macrolide that stabilises malignant cells' microtubules and arrests mitosis, a characteristic it shares with other epothilones. They bind to the same hepatic sites as does paclitaxel (Taxol) in a 1:1 stoichiometric ratio of a, b-tubulin heterodimers.
![193146-26-8](/CAS2/GIF/193146-26-8.gif)
![189453-35-8](/CAS2/GIF/189453-35-8.gif)
Synthesis of (4S,7R,8S,9S,13Z,16S)-4,8-Bis-{[tert-butyl(dimethyl)silyl]oxy}-5,5,7,9,13-pentamethyl-16-[(E)-1-methyl-2-(2-methyl-1,3-thiazol-4-yl)ethenyl]oxocyclohexadec-13-ene-2,6-dione from (3S,6R,7S,12Z,15S,16E)-3,7-Bis-{[tert-butyl(dimethyl)silyl]oxy}-15-hydroxy-4,4,6,8,12,16-hexamethyl-17-(2-methyl-1,3-thiazol-4-yl)-5-oxoheptadeca-12,16-dienoic Acid
(4S,7R,8S,9S,13Z,16S)-4,8-Bis-{[tert-butyl(dimethyl)silyl]oxy}-5,5,7,9,13-pentamethyl-16-[(E)-1-methyl-2-(2-methyl-1,3-thiazol-4-yl)ethenyl]oxocyclohexadec-13-ene-2,6-dione Preparation Products And Raw materials
(4S,7R,8S,9S,13Z,16S)-4,8-Bis-{[tert-butyl(dimethyl)silyl]oxy}-5,5,7,9,13-pentamethyl-16-[(E)-1-methyl-2-(2-methyl-1,3-thiazol-4-yl)ethenyl]oxocyclohexadec-13-ene-2,6-dione Suppliers
Global( 11)Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 94658 | 76 |
3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
Chemsky(shanghai)International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32344 | 50 |
S.Z. PhyStandard Bio-Tech. Co., Ltd. | 0755-83725681-603 | China | 4505 | 50 | |
Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 13028896684 | sales@rrkchem.com | China | 56070 | 58 |
Energy Chemical | 021-58432009 400-005-6266 | marketing1@energy-chemical.com | China | 44843 | 58 |
Carbosynth | -- | sales@carbosynth.com | United Kingdom | 6018 | 58 |
189453-35-8((4S,7R,8S,9S,13Z,16S)-4,8-Bis-{[tert-butyl(dimethyl)silyl]oxy}-5,5,7,9,13-pentamethyl-16-[(E)-1-methyl-2-(2-methyl-1,3-thiazol-4-yl)ethenyl]oxocyclohexadec-13-ene-2,6-dione)Related Search:
(4S,5R)-3-(tert-Butoxycarbonyl)-2,2-dimethyl-4-phenyloxazolidine-5-carboxylic acid
7-Xylosyl-10-deacetyltaxol
Paclitaxel Impurity 9
N-Desbenzoyl-N-tert-butoxycarbonyl-N,O-isopropylidene-3a€-p-O-benzyl-6,7-dehydro Paclitaxel
2'-O-(Benzyloxycarbonyl) Taxol
(4S,5R)-3-Benzoyl-2-(4-methoxyphenyl)-4-phenyl-5-oxazolidinecarboxylic acid
6-CHLORO-4-CHLOROMETHYL-7-HYDROXY-CHROMEN-2-ONE
Epothilone B
4-(BENZYLOXYCARBONYLAMINO-METHYL)-BENZOIC ACID
2'-O-tert-Butyl(diMethyl)silyl-7-O-triethylsilyl-2-debenzoyl-4-desacetyl Paclitaxel
(αR,βS)-β-[[(1,1-DiMethylethoxy)carbonyl]aMino]-α-hydroxy-4-(phenylMethoxy)-benzenepropanoic Acid Ethyl Ester
BOC-3-ENDO-AMINOBICYCLO[2.2.1]HEPTANE-2-ENDO-CARBOXYLIC ACID
(4S,5R)-2,2-DiMethyl-4-[4-(phenylMethoxy)phenyl]-N-DiMethylethoxycarbonyl-3,5-oxazolidinecarboxylic Acid Ethyl Ester
13-{[(3-N-Boc)-2,2-dimethyl-4S-phenyl-1,3-oxazolidin-5R-yl]formyl}-7-O-(triethylsilyl) Baccatin III
Docetaxel-D9
1of4
(4S,7R,8S,9S,13Z,16S)-4,8-Bis-{[tert-butyl(dimethyl)silyl]oxy}-5,5,7,9,13-pentamethyl-16-[(E)-1-methyl-2-(2-methyl-1,3-thiazol-4-yl)ethenyl]oxocyclohexadec-13-ene-2,6-dione
[4S-[4R*,7S*,8R*,9R*,13Z,16R*(E)]]-4,8-Bis[[(1,1-diMethylethyl)diMethylsilyl]oxy]-
Oxacyclohexadec-13-ene-2,6-dione, 4,8-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-5,5,7,9,13-pentamethyl-16-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-, (4S,7R,8S,9S,13Z,16S)-
Paclitaxel Impurity 73
(4S,7R,8S,9S,13Z,16S)-4,8-Bis-{[Tert-Butyl(Dimethyl)Silyl]Oxy}-5,5,7,9,13-Pentamethyl-16-[(E)-1-Methyl-2-(2-Methyl-1,3-Thiazol-4-Yl)Ethenyl]Oxcyclohexadec-13-Ene-2,6-Dione
189453-35-8
Chiral Reagents