Terbogel
- CAS No.
- 149979-74-8
- Chemical Name:
- Terbogel
- Synonyms
- Terbogel;terbogrel;BIBV 308SE;(E)-6-[3-[(N'-tert-butyl-N-cyanocarbamimidoyl)amino]phenyl]-6-pyridin-3-ylhex-5-enoic acid;5-Hexenoic acid, 6-[3-[[(cyanoamino)[(1,1-dimethylethyl)amino]methylene]amino]phenyl]-6-(3-pyridinyl)-, (5E)-
- CBNumber:
- CB51179876
- Molecular Formula:
- C23H27N5O2
- Molecular Weight:
- 405.49
- MDL Number:
- MFCD00923101
- MOL File:
- 149979-74-8.mol
| Boiling point | 613.5±65.0 °C(Predicted) |
|---|---|
| Density | 1.13±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | Soluble in DMSO |
| pka | 4.66±0.10(Predicted) |
| FDA UNII | 5Z4KWQ5OGN |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
Terbogel price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| CSNpharm | CSN21854 | Terbogrel | 149979-74-8 | 1mg | $1469 | 2021-12-16 | Buy |
| CSNpharm | CSN21854 | Terbogrel | 149979-74-8 | 5mg | $3305 | 2021-12-16 | Buy |
| CSNpharm | CSN21854 | Terbogrel | 149979-74-8 | 10mg | $5620 | 2021-12-16 | Buy |
| CSNpharm | CSN21854 | Terbogrel | 149979-74-8 | 25mg | $9914 | 2021-12-16 | Buy |
Terbogel Chemical Properties,Uses,Production
Definition
ChEBI: Terbogrel is a diterpene glycoside.
Biological Activity
Terbogrel is an orally available thromboxane A2 receptor antagonist and inhibitor of thromboxane A2 synthase with IC50 values of approximately 10 nM.
in vitro
Pretreatment of platelets with terbogrel 1 μM completely inhibits thrombin-induced thromboxane A2 formation (2±1 ng/mL) but does not result in any inhibition of platelet aggregation. Terbogrel (1 μM) completely inhibits U46619-induced thromboxane A2 formation (2±1 ng/mL) but does not result in any inhibition of platelet aggregation. platelet aggregation, and the IC 50 value is 10 nM. Terbogrel inhibits both platelet aggregation and thromboxane A2 formation with an IC 50 of about 10 nM. It inhibits the thromboxane A2 synthase in human gel-filtered platelets with an IC 50 value of 4.0 ± 0.5 nM. Terbogrel blocks the thromboxane A2/endoperoxide receptor on washed human platelets with an IC 50 of 11 ± 6 nM (n = 2) and with an IC 50 of 38 ± 1 nM (n = 15) in platelet-rich plasma. Terbogrel inhibits the collagen-induced platelet aggregation in human platelet-rich plasma and whole blood with an IC 50 of 310 ± 18 nM (n = 8) and 52 ± 20 nM (n = 6), respectively.
in vivo
Terbogrel (0.1?3.0 mg/kg) demonstrates an impressive antithrombotic efficacy in rabbits. It (10 mg/kg, po) is rapidly and well (90%) absorbed with a systemic availability of about 30% in rats.
target
IC50: apr 10 nM (thromboxane A2 receptor), appr 10 nM (thromboxane A2 synthase)
Terbogel Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4863 | 58 |
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9730 | 58 |
| Hubei Nordina Biotechnology Co., Ltd. | 19371278702 | nuodinashengwu@163.com | China | 972 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24651 | 58 |
| Suzhou Meishi Biotechnology Co., Ltd. | 1173954148q | meishipharma@126.com | China | 20035 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11975 | 58 |