ChemicalBook >> CAS DataBase List >>2-Propenamide, N-[4-(1-benzoyl-4-piperidinyl)butyl]-3-(3-pyridinyl)-, hydrochloride (1:1), (2E)-

2-Propenamide, N-[4-(1-benzoyl-4-piperidinyl)butyl]-3-(3-pyridinyl)-, hydrochloride (1:1), (2E)-

2-Propenamide, N-[4-(1-benzoyl-4-piperidinyl)butyl]-3-(3-pyridinyl)-, hydrochloride (1:1), (2E)- structure

CAS No.: 2727965-45-7

Chemical Name:: 2-Propenamide, N-[4-(1-benzoyl-4-piperidinyl)butyl]-3-(3-pyridinyl)-, hydrochloride (1:1), (2E)-

Synonyms: 2-Propenamide, N-[4-(1-benzoyl-4-piperidinyl)butyl]-3-(3-pyridinyl)-, hydrochloride (1:1), (2E)-

CBNumber:: CB512110109

Molecular Formula:: C24H30ClN3O2

Molecular Weight:: 427.97

MDL Number:

MOL File:: 2727965-45-7.mol

Last updated:2023-06-30 15:45:59

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2-Propenamide, N-[4-(1-benzoyl-4-piperidinyl)butyl]-3-(3-pyridinyl)-, hydrochloride (1:1), (2E)- Properties

solubility	Soluble to 5 mM in water with gentle warming and to 100 mM in DMSO

2-Propenamide, N-[4-(1-benzoyl-4-piperidinyl)butyl]-3-(3-pyridinyl)-, hydrochloride (1:1), (2E)- Chemical Properties,Uses,Production

Biological Activity

FK 866 hydrochloride is a non-competitive and potent inhibitor of NAMPT (nicotinamide phosphoribosyltransferase, PBEF1) (Ki = 0.3 nM); inhibits NAD biosynthesis. Induces delayed cell death by apoptosis in HepG2 human liver carcinoma cells (IC50 ~1 nM). Induces apoptosis in four different neuroblastoma cell lines; also induces autophagy in SH-SY5Y cells. Potentiates the cytotoxic effects induced by etoposide and cisplatin .

storage

Store at -20°C

2-Propenamide, N-[4-(1-benzoyl-4-piperidinyl)butyl]-3-(3-pyridinyl)-, hydrochloride (1:1), (2E)- Preparation Products And Raw materials

Raw materials

Preparation Products

2-Propenamide, N-[4-(1-benzoyl-4-piperidinyl)butyl]-3-(3-pyridinyl)-, hydrochloride (1:1), (2E)- Suppliers

Global( 2)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9806	58
Jinan Jiuli Biotechnology Co. , Ltd.	15865264761	486064515@qq.com	China	3543	58

Supplier	Advantage
Shanghai EFE Biological Technology Co., Ltd.	58
Jinan Jiuli Biotechnology Co. , Ltd.	58

2-Propenamide, N-[4-(1-benzoyl-4-piperidinyl)butyl]-3-(3-pyridinyl)-, hydrochloride (1:1), (2E)- 2727965-45-7