BENAZEPRIL HCL
- CAS No.
- 3202-55-9
- Chemical Name:
- BENAZEPRIL HCL
- Synonyms
- ap1288;brl1288;Benapryzine HCl;benapryzinehydrochloride;Benaprizine Hydrochloride;benzilicacid,2-(ethylpropylamino)ethylester,hydrochloride;alpha-hydroxy-alpha-phenyl-benzeneaceticaci2-(ethylpropylamino)ethyles
- CBNumber:
- CB5122019
- Molecular Formula:
- C24H29ClN2O5
- Molecular Weight:
- 460.95
- MDL Number:
- MFCD01668249
- MOL File:
- 3202-55-9.mol
| Melting point | 164-166° |
|---|---|
| FDA UNII | LNV63FWR8M |
BENAZEPRIL HCL Chemical Properties,Uses,Production
Originator
Brizin,Beecham,UK,1973
Uses
Anticholinergic.
Manufacturing Process
A methanolic solution of sodium methoxide [from sodium (0.2 gram) and dry
methanol (3 ml)] was added dropwise during 20 minutes to a boiling solution
of methyl α,α-diphenylglycollate (11 grams) and 2-ethylpropylaminoethanol (6
grams) in light petroleum (150 ml, BP 80°-100°C) and the methanol that
separated was removed by using a Dean and Starke apparatus. At the end of
5 hours no further separation of methanol occurred and the reaction mixture
after being washed with water (3 x 20 ml) was extracted with 1N hydrochloric
acid (3 x 30 ml).
The acid extracts (after washing with 50 ml ether) were made alkaline with
aqueous 5 N sodium hydroxide solution, the liberated base was extracted into
ether (4 x 50 ml) and the ether extracts were dried (MgSO4). Treatment of
the extracts with hydrogen chloride gave the hydrochloride (11 grams, 70%),
which was obtained as rectangular plates, MP 164° to 166°C, after several
crystallizations from butanone.
Therapeutic Function
Anticholinergic, Antiparkinsonian
BENAZEPRIL HCL Preparation Products And Raw materials
BENAZEPRIL HCL Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Hao Zhun Biological Technology Co., Ltd. | -- | info@zzsrm.com | CHINA | 6650 | 58 |
| Sequoia Research Products Ltd. | -- | sales@seqchem.com | United Kingdom | 3113 | 69 |
| MDP ChemControl Ltd. | -- | chemcontrol@nextra.sk | Slovakia | 6700 | 60 |
| Supplier | Advantage |
|---|---|
| Shanghai Hao Zhun Biological Technology Co., Ltd. | 58 |
| Sequoia Research Products Ltd. | 69 |
| MDP ChemControl Ltd. | 60 |