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9-Aminocamptothecin

9-Aminocamptothecin Structure
9-Aminocamptothecin structure
CAS No.
91421-43-1
Chemical Name:
9-Aminocamptothecin
Synonyms
NSC-603071;1H-Pyrano(3;AMinocaMptothecin;9-AMINO-CAMPTOTHECIN;CAMPTOTHECIN, 9-AMINO-;9-Aminocamptothecin >Camptothecin Impurity 14;(20S)-9-AMINOCAMPTOTHECIN;9-Aminocamptothecin, >96%;9-amino-2(S)-camptothecin
CBNumber:
CB5125434
Molecular Formula:
C20H17N3O4
Molecular Weight:
363.37
MDL Number:
MFCD00909855
MOL File:
91421-43-1.mol
MSDS File:
SDS
Last updated:2024-11-19 20:33:22
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9-Aminocamptothecin Properties

Melting point 142.0-145.0 °C
Boiling point 819.6±65.0 °C(Predicted)
Density 1.55±0.1 g/cm3(Predicted)
storage temp. 2-8°C(protect from light)
solubility ≤1mg/ml in DMSO;1mg/ml in dimethyl formamide
form powder to crystal
pka 11.23±0.20(Predicted)
color Light yellow to Yellow to Orange
Merck 14,431
InChIKey FUXVKZWTXQUGMW-FQEVSTJZSA-N
CAS DataBase Reference 91421-43-1(CAS DataBase Reference)
FDA UNII 5MB77ICE2Q
NCI Dictionary of Cancer Terms aminocamptothecin
NCI Drug Dictionary aminocamptothecin

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P280-P305+P351+P338
RTECS  UQ0490500
HS Code  29349990
NFPA 704
0
2 0

9-Aminocamptothecin price More Price(46)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical A2063 9-Aminocamptothecin >95.0%(HPLC) 91421-43-1 10mg $485 2024-03-01 Buy
Cayman Chemical 17232 9-amino Camptothecin ≥95% 91421-43-1 1mg $32 2024-03-01 Buy
Cayman Chemical 17232 9-amino Camptothecin ≥95% 91421-43-1 5mg $139 2024-03-01 Buy
Cayman Chemical 17232 9-amino Camptothecin ≥95% 91421-43-1 10mg $184 2024-03-01 Buy
Cayman Chemical 17232 9-amino Camptothecin ≥95% 91421-43-1 25mg $381 2024-03-01 Buy
Product number Packaging Price Buy
A2063 10mg $485 Buy
17232 1mg $32 Buy
17232 5mg $139 Buy
17232 10mg $184 Buy
17232 25mg $381 Buy

9-Aminocamptothecin Chemical Properties,Uses,Production

Uses

9-Amino Camptothecin is a derivative of Camptothecin (C175150), as antitumor agent.

Definition

ChEBI: 9-Aminocamptothecin is a pyranoindolizinoquinoline.

Biological Activity

9-amino camptothecin is a topoisomerase i inhibitor [1][2].dna topoisomerases relax dna torsional strain generated during replication, transcription, recombination, repair, and chromosome condensation. the relaxation of dna supercoiling by topoisomerase i is enabled by a mechanism of controlled rotation around a transient dna single-strand break. camptothecin (cpt) is isolated from the bark of the chinese tree camptotheca accuminata [3].9-amino camptothecin, a water-soluble camptothecin analogue, is a topoisomerase i inhibitor. in human ht-29 colon adenocarcinoma, 9-amino camptothecin (9-ac) exhibited cytotoxicity with ic50 value of 19 nm. 9-ac also induced dna damage in whole cells and nuclei at a concenstration of 85 nm and 21 nm, respectively [1].9-amino camptothecin had greater activity than camptothecin against human tumour xenografts, including lewis lung carcinoma and b16 melanoma. 9-ac had entered phase ii trials. in patients with advanced solid tumours, 9-amino camptothecin exhibited anti-tumor activity [1][2].

References

[1]. rothenberg, m.l. topoisomerase i inhibitors: review and update. annals of oncology 8(9), 837-855 (1997).
[2]. dancey j, eisenhauer ea. current perspectives on camptothecins in cancer treatment. br j cancer. 1996 aug;74(3):327-38.
[3]. drwal mn1, agama k, wakelin lp, et al. exploring dna topoisomerase i ligand space in search of novel anticancer agents. plos one. 2011;6(9):e25150.

9-Aminocamptothecin Preparation Products And Raw materials

Raw materials

Preparation Products

9-Aminocamptothecin Suppliers

Global( 204)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai Zheyan Biotech Co., Ltd. 		18017610038 zheyansh@163.com CHINA 3619 58
Chengdu GLP biotechnology Co Ltd 		028-87075086 13350802083 scglp@glp-china.com CHINA 1824 58
Hubei Jusheng Technology Co.,Ltd. 		18871490254 linda@hubeijusheng.com CHINA 28172 58
Shochem(Shanghai) Co.,Ltd 		86-21-50800795 info@shochem.com CHINA 288 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19553 58
Chongqing Chemdad Co., Ltd 		+86-023-6139-8061 +86-86-13650506873 sales@chemdad.com China 39894 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49374 58
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29811 58
SIMAGCHEM CORP 		+86-13806087780 sale@simagchem.com China 17365 58
Supplier Advantage
Shanghai Zheyan Biotech Co., Ltd. 		58
Chengdu GLP biotechnology Co Ltd 		58
Hubei Jusheng Technology Co.,Ltd. 		58
Shochem(Shanghai) Co.,Ltd 		58
BOC Sciences 		58
Chongqing Chemdad Co., Ltd 		58
Alchem Pharmtech,Inc. 		58
CONIER CHEM AND PHARMA LIMITED 		58
career henan chemical co 		58
SIMAGCHEM CORP 		58

View Lastest Price from 9-Aminocamptothecin manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
9-amino-CPT pictures 2024-11-19 9-amino-CPT
91421-43-1
 US $35.00-93.00 / mg 99.82% 10g TargetMol Chemicals Inc.
9-Aminocamptothecin pictures 2022-10-14 9-Aminocamptothecin
91421-43-1
 US $0.00-0.00 / KG 1KG 98% 1Ton Henan Aochuang Chemical Co.,Ltd.
9-Aminocamptothecin pictures 2020-07-27 9-Aminocamptothecin
91421-43-1
 US $0.00-0.00 / g 1g 95% 1kg/month Shochem(Shanghai) Co.,Ltd
  • 9-amino-CPT pictures
  • 9-amino-CPT
    91421-43-1
  • US $35.00-93.00 / mg
  • 99.82%
  • TargetMol Chemicals Inc.

9-Aminocamptothecin Spectrum

9-Aminocamptothecin(91421-43-1)1HNMR

91421-43-1(9-Aminocamptothecin)Related Search:

10-Hydroxycamptothecin Glycine Betaine (+)-Camptothecin ALTRENOGEST
4-Ethyl-4,10-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione Rubitecan 9-methoxy-7-ethylcamptothecin 7-ETHYL-10-HYDROXYCAMPTOTHECIN,98% Camptothecin
20R-Camptothecin 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4,11-diethyl-4-hydroxy-9-methoxy-, (4S)- SN-38-D3 7-Ethyl-20(R)-camptothecin 9-amino-20-camptothecin
Hydroxyl camptothecine AMINO ACIDS 9-Aminocamptothecin

1of4

4':6,7)indolizino(1,2-B)quinoline-3,14(4H,12H)-dione 4':6,7)indolizino(1,2-B)quinoline-3,14(4H,12H)-dione, 10-amino-4-ethyl-4-hydroxy-, (S)- CAMPTOTHECIN, 9-AMINO-(RG) (S)-10-AMino-4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione (S)-10-Amino-4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]-indolizino[1,2-b]quinoline-3,14(4H,12H)-di CAMPTOTHECIN, 9-AMINO- AMinocaMptothecin 9-AMINO-CAMPTOTHECIN 9-Amino-20-(S)-camptothecin 10-amino-4(s)-4-ethyl-4-hydroxy-1h-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4h,12h)-dione (20S)-9-AMINOCAMPTOTHECIN 9-Aminocamptothecin，9-Amino-20-(S)-camptothecin (4S)-4α-Ethyl-4,12-dihydro-4-hydroxy-10-amino-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-dione 9-Amino-20(S)-camptothecine NSC-603071 (S)-10-Amino-4-ethyl-4-hydroxy-1H-pyrano(3 1H-Pyrano(3 9-Aminocamptothecin, >96% 2-aminobenzoic acid [(2R,3S,4R,5S)-5-(6-aminopurin-9-yl)-4-hydroxy-2-[[hydroxy-[hydroxy(phosphonooxy)phosphoryl]oxyphosphoryl]oxymethyl]-3-oxolanyl] ester 9-Aminocamptothecin, 98%, from the fruit of Camptotheca acuminata Decne. 9-Aminocamptothecin > 9-amino-2(S)-camptothecin 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 10-amino-4-ethyl-4-hydroxy-, (4S)- Camptothecin Impurity 14 91421-43-1 C20H17N3O4 Pharmaceutical Raw Materials Alkaloids Natural Anti-cancer Medical Materials and It's Derivatives