ChemicalBook >> CAS DataBase List >>Pyrido[3,2-d]pyrimidine-2,4-diamine, 7-fluoro-N2-[1-(2-methyl-2-azaspiro[3.3]hept-6-yl)-1H-pyrazol-4-yl]-N4-(1-methylethyl)-6-(2-methyl-5-pyrimidinyl)-

Pyrido[3,2-d]pyrimidine-2,4-diamine, 7-fluoro-N2-[1-(2-methyl-2-azaspiro[3.3]hept-6-yl)-1H-pyrazol-4-yl]-N4-(1-methylethyl)-6-(2-methyl-5-pyrimidinyl)-

Pyrido[3,2-d]pyrimidine-2,4-diamine, 7-fluoro-N2-[1-(2-methyl-2-azaspiro[3.3]hept-6-yl)-1H-pyrazol-4-yl]-N4-(1-methylethyl)-6-(2-methyl-5-pyrimidinyl)- structure

CAS No.: 2667681-85-6

Chemical Name:: Pyrido[3,2-d]pyrimidine-2,4-diamine, 7-fluoro-N2-[1-(2-methyl-2-azaspiro[3.3]hept-6-yl)-1H-pyrazol-4-yl]-N4-(1-methylethyl)-6-(2-methyl-5-pyrimidinyl)-

Synonyms: IRAK4-IN-15;Pyrido[3,2-d]pyrimidine-2,4-diamine, 7-fluoro-N2-[1-(2-methyl-2-azaspiro[3.3]hept-6-yl)-1H-pyrazol-4-yl]-N4-(1-methylethyl)-6-(2-methyl-5-pyrimidinyl)-

CBNumber:: CB512716569

Molecular Formula:: C25H29FN10

Molecular Weight:: 488.56

MDL Number:

MOL File:: 2667681-85-6.mol

Last updated:2025-04-18 09:52:24

Request For Quotation

Pyrido[3,2-d]pyrimidine-2,4-diamine, 7-fluoro-N2-[1-(2-methyl-2-azaspiro[3.3]hept-6-yl)-1H-pyrazol-4-yl]-N4-(1-methylethyl)-6-(2-methyl-5-pyrimidinyl)- Properties

Boiling point	705.6±70.0 °C(Predicted)
Density	1.49±0.1 g/cm3(Predicted)
pka	9.50±0.40(Predicted)

Pyrido[3,2-d]pyrimidine-2,4-diamine, 7-fluoro-N2-[1-(2-methyl-2-azaspiro[3.3]hept-6-yl)-1H-pyrazol-4-yl]-N4-(1-methylethyl)-6-(2-methyl-5-pyrimidinyl)- Chemical Properties,Uses,Production

Uses

IRAK4-IN-15 (compound 35) is a potent and selective IRAK4 inhibitor with an IC50 of 0.002 μM. IRAK4-IN-15 shows good human PK predictions with low intrinsic clearance. IRAK4-IN-15 shows great synergistic in vitro activity against MyD88/CD79 double mutant ABC-DLBCL in combination with Acalabrutinib. [1].

IC 50

IRAK4: 0.002 μM (IC₅₀)

References

[1] Degorce SL, et al. Improving metabolic stability and removing aldehyde oxidase liability in a 5-azaquinazoline series of IRAK4 inhibitors. Bioorg Med Chem. 2020 Dec 1;28(23):115815. DOI:10.1016/j.bmc.2020.115815

Pyrido[3,2-d]pyrimidine-2,4-diamine, 7-fluoro-N2-[1-(2-methyl-2-azaspiro[3.3]hept-6-yl)-1H-pyrazol-4-yl]-N4-(1-methylethyl)-6-(2-methyl-5-pyrimidinyl)- Preparation Products And Raw materials

Raw materials

Preparation Products

Pyrido[3,2-d]pyrimidine-2,4-diamine, 7-fluoro-N2-[1-(2-methyl-2-azaspiro[3.3]hept-6-yl)-1H-pyrazol-4-yl]-N4-(1-methylethyl)-6-(2-methyl-5-pyrimidinyl)- Suppliers

Global( 1)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	19784	58

Supplier	Advantage
TargetMol Chemicals Inc.	58

Pyrido[3,2-d]pyrimidine-2,4-diamine, 7-fluoro-N2-[1-(2-methyl-2-azaspiro[3.3]hept-6-yl)-1H-pyrazol-4-yl]-N4-(1-methylethyl)-6-(2-methyl-5-pyrimidinyl)- IRAK4-IN-15 2667681-85-6 C25H29FN10