irisolidone
- CAS No.
- 2345-17-7
- Chemical Name:
- irisolidone
- Synonyms
- irisoidone;irisolidone;4'-Methoxytectorigenin;4'-O-Methyltectorigenin;5,7-Dihydroxy-6,4'-dimethoxyisoflavon;5,7-dihydroxy-6-methoxy-3-(4-methoxyphenyl)-4H-chromen-4-one;5,7-Dihydroxy-6-methoxy-3-(4-methoxyphenyl)-4H-1-benzopyran-4-one;4H-1-Benzopyran-4-one, 5,7-dihydroxy-6-methoxy-3-(4-methoxyphenyl)-;Chloride Channel,Cl? Channels,Inhibitor,hepatoprotective,inhibit,VRAC,Irisolidone
- CBNumber:
- CB51330783
- Molecular Formula:
- C17H14O6
- Molecular Weight:
- 314.29
- MDL Number:
- MOL File:
- 2345-17-7.mol
| Melting point | 190-191 °C |
|---|---|
| Boiling point | 565.5±50.0 °C(Predicted) |
| Density | 1.402±0.06 g/cm3(Predicted) |
| storage temp. | 4°C, protect from light |
| solubility | Chloroform (Slightly), DMSO (Slightly) |
| pka | 6.48±0.20(Predicted) |
| form | Solid |
| color | Off-White to Pale Yellow |
| EWG's Food Scores | 1 |
| FDA UNII | 081ORX70ZR |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319 |
| Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 |
irisolidone Chemical Properties,Uses,Production
Description
Irisolidone is a hydrolyzed product of kudzurin. Studies have shown that it can significantly dilate coronary arteries, cerebral arteries and peripheral blood vessels and microvessels, and can reduce vascular resistance, cholesterol and blood viscosity.
Chemical Properties
Light yellow crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from kudzu.
Uses
Irisolidone has anti-inflammatory, antioxidant, antibacterial, anti-tumor, estrogen-like effects, and protects liver damage caused by alcoholism.
Definition
ChEBI: Irisolidone is a member of 4'-methoxyisoflavones.
Biological Activity
Irisolidone is the main isoflavone in pueraria. Irisolidone has strong hepatoprotective activity. It has a highly effective blocking effect on the anion channel VRAC.
in vitro
Irisolidone shows the high efficacy for Volume-regulated anion channels (VRAC) blockade with an IC 50 of 9.8 μM in HEK293 cells.
It can inhibit endothelial cell proliferation.
irisolidone Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chengdu Greenpure Biopharma CO.,Ltd | 18283602253; +8618283602253 | jancyzheng@gcgreenpure.com | China | 953 | 58 |
| Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 | scglp@glp-china.com | CHINA | 1824 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | sales@biopurify.com | China | 3772 | 58 |
| Shaanxi Pioneer Biotech Co., Ltd . | +8613259417953 | sales@pioneerbiotech.com | China | 3000 | 58 |
| Wuhan ChemNorm Biotech Co.,Ltd. | +86-27-8439 4403 18971486879 | sales@chemnorm.com | CHINA | 2935 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23541 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38632 | 58 | |
| Jilin Chinese Academy of Sciences-yanshen Technology | +undefined18143011203 | info@chemextension.com | China | 42056 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52924 | 58 |
| Mensura Group Limited | +8618109034517 | hkd008@vacorda.com | China | 2900 | 58 |
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