ANTI-CHLORIDE CHANNEL CLC-2
- CAS No.
- Chemical Name:
- ANTI-CHLORIDE CHANNEL CLC-2
- Synonyms
- Anti-ClC-2;Anti-PPL13;Anti-MGC22235;ANTI-HUMAN CLC-2;ANTI-CLC-2 CHLORIDE CHANNEL;ANTI-CHLORIDE CHANNEL CLC-2;Anti-Chloride channel protein 2;Anti-CLCN2 antibody produced in rabbit;ANTI-CHLORIDE CHANNEL-2 (CLC-2, CLCN2);Anti-LGALS14, (N-terminal) antibody produced in rabbit
- CBNumber:
- CB5136050
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MFCD02096079
- MOL File:
- Mol file
ANTI-CHLORIDE CHANNEL CLC-2 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | HPA014545 | Anti-CLCN2 antibody produced in rabbit Prestige Antibodies? Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution | 100μL | $580 | 2024-03-01 | Buy | |
| Sigma-Aldrich | HPA014545 | Anti-CLCN2 antibody produced in rabbit Prestige Antibodies? Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution | 25μL | $282 | 2023-06-20 | Buy | |
| Sigma-Aldrich | C9477 | Anti-Chloride Channel-2 (CLC-2, Clcn2) antibody produced in rabbit affinity isolated antibody, lyophilized powder | 0.2ML | $755 | 2022-05-15 | Buy |
ANTI-CHLORIDE CHANNEL CLC-2 Chemical Properties,Uses,Production
Uses
All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry.
The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit .
General Description
CLCN2 (chloride channel, voltage-sensitive 2) is a member of the voltage gated Cl- channels and Cl-/H+ exchangers called ClC family of proteins. The mammalian family consists of nine members including CLCN2. This protein has a ubiquitous expression pattern. It has a predominant expression in brain, pancreas, kidney and intestine. This protein is localized intracellulary in the basolateral membrane of polarized cells. It exists as aggregates on the cell surface, and some proportion of it localized with lipid rafts. This protein consists of two putative phosphorylation sites in its N-terminal, and seven in its C-terminal.
Biochem/physiol Actions
CLCN2 (chloride channel, voltage-sensitive 2) has a high level of expression in the brain, where it mediates inhibitory γ-aminobutyric acid (GABA) response. It maintains low intracellular Cl- levels, to achieve this. Hyperpolarization of membrane and intracellular anion concentration activate CLCN2, and it is involved in solute transport across epithelial cells. It is expressed in lung epithelia, where it is capable of Cl- transport. It might also be involved in the morphogenesis of lungs. In astrocytes, this protein is involved in the maintenance of extracellular electrolyte homeostasis. Mutation M200fsX231 produces an extremely truncated CLCN2 protein, and might be linked with idiopathic generalized epilepsy. Studies also suggest that this protein might be associated with atherosclerosis and constipation-associated irritable bowel disease. Studies show that the susceptibility to a subset of childhood absence epilepsies maybe linked to CLCN2 gene locus.
ANTI-CHLORIDE CHANNEL CLC-2 Preparation Products And Raw materials
Raw materials
Preparation Products
ANTI-CHLORIDE CHANNEL CLC-2 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Riedel-de Haen AG | -- | United States | 6825 | 87 | |
| SIGMA-RBI | -- | Switzerland | 6913 | 91 | |
| MP Biomedicals, Inc. | -- | United States | 6566 | 81 | |
| Nacalai Tesque, Inc. | -- | info-tech@nacalai.co.jp | Japan | 6048 | 75 |
| Chemicon Internatinal, Inc. | -- | custserv@chemicon.com | United States | 4175 | 65 |
| Supplier | Advantage |
|---|---|
| Riedel-de Haen AG | 87 |
| SIGMA-RBI | 91 |
| MP Biomedicals, Inc. | 81 |
| Nacalai Tesque, Inc. | 75 |
| Chemicon Internatinal, Inc. | 65 |