2-((2-(dimethylamino)ethyl)thio)-3-phenylquinoline
- CAS No.
- 85273-95-6
- Chemical Name:
- 2-((2-(dimethylamino)ethyl)thio)-3-phenylquinoline
- Synonyms
- ZM 169369;ICI-169369;2-((2-(dimethylamino)ethyl)thio)-3-phenylquinoline;N,N-Dimethyl-2-[(3-phenylquinolin-2-yl)thio]ethanamine;Ethanamine, N,N-dimethyl-2-[(3-phenyl-2-quinolinyl)thio]-
- CBNumber:
- CB51361259
- Molecular Formula:
- C19H20N2S
- Molecular Weight:
- 308.44
- MDL Number:
- MFCD28047481
- MOL File:
- 85273-95-6.mol
| Boiling point | 452.0±45.0 °C(Predicted) |
|---|---|
| Density | 1.17±0.1 g/cm3(Predicted) |
| pka | 8.51±0.28(Predicted) |
| FDA UNII | 4CT4CS5BA7 |
2-((2-(dimethylamino)ethyl)thio)-3-phenylquinoline Chemical Properties,Uses,Production
Uses
ICI 169369 (free base) is an orally active, selective and non-competitive antagonist against 5HT receptor. ICI 169369 (free base) blunts the vasopressin (AVP), but not the ACTH, prolactin or growth hormone reponses to insulin-induced hypoglycaemia. ICI 169369 (free base) blocks centrally mediated 5-HT responses and lowers portal pressure in portal hypertensive rats[1][2][3][4].
References
[1] Thompson CJ, et al. The effects of the specific serotonin antagonist ICI 169,369 on the pituitary hormone response to insulin-induced hypoglycaemia in humans. Clin Endocrinol (Oxf). 1992 Mar;36(3):235-40. DOI:10.1111/j.1365-2265.1992.tb01438.x
[2] Blackburn TP, et al. In vitro studies with ICI 169,369, a chemically novel 5-HT antagonist. Eur J Pharmacol. 1988 Jun 10;150(3):247-56. DOI:10.1016/0014-2999(88)90005-2
[3] Kaumann A J, et al. ICI 169,369 selectively blocks 5-hydroxytryptamine2 receptors and lowers portal pressure in portal hypertensive rats[J]. Gastroenterology, 1988, 95(6): 1601-1606. DOI:10.1016/s0016-5085(88)80084-2
[4] Blackburn TP, et al. Pharmacological studies in vivo with ICI 169,369, a chemically novel 5-HT2/5-HT1C receptor antagonist. Eur J Pharmacol. 1990 May 16;180(2-3):229-37. DOI:10.1016/0014-2999(90)90306-q
2-((2-(dimethylamino)ethyl)thio)-3-phenylquinoline Preparation Products And Raw materials
Raw materials
Preparation Products
2-((2-(dimethylamino)ethyl)thio)-3-phenylquinoline Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32159 | 58 |
| TargetMol Chemicals Inc. | +8613564774135 | zijue.cai@tsbiochem.com | United States | 19881 | 58 |
| Shanghai Chaolan Chemical Technology Center | 021-QQ：65489617 15618227136 | Sales@ATKchemical.com | China | 9323 | 58 |
| Nanjing KaiMubo Pharmaceutical Co., Ltd. | 025-66162170 | China | 7181 | 55 | |
| Shanghai Dongyang Biotechnology Co., Ltd. | 0512-0512-13601744364 13601744364 | chemsharker@126.com | China | 947 | 58 |
| Hubei wei shi reagent group ltd., company | 027-59102966 18717199209 | 2853877583@qq.com | China | 2990 | 58 |
| Changzhou Bojia Biomedical Technology Co., Ltd. | 2122619822 | czbjpharma@126.com | China | 18478 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24641 | 58 |
