Poliovirus Vaccine, Inactivated

General Description

There are several synonyms for the IPV vaccine: IPV, e-IPV,ep-IPV, and the Salk vaccine (1954 [IPOL, Aventis-Pasteur]). e-IPV is an enhanced potency poliovirus, morepotent and immunogenic than any of the previous IPV formulations.e-IPV is recommended for all four infant dosesbecause of the incidence of rare cases of oral polio vaccine(OPV)–associated paralytic poliomyelitis. e-IPV is also preferredfor adults for the same reason. IPV is a trivalent(strains 1, 2, 3) vaccine grown in monkey kidney culture andsubjected to elaborate precautions to ensure inactivation(typically, formaldehyde is used). The antigen form is whole virus. The antigen type is protein. The vaccine is injected tocause induction of active systemic immunity from polio butdoes not stop polio carriers, who shed the virus from the oraland nasal cavities.