1,4,7-triazacyclononane-N,N',N''-triacetic acid
- CAS No.
- 56491-86-2
- Chemical Name:
- 1,4,7-triazacyclononane-N,N',N''-triacetic acid
- Synonyms
- NOTA;2,2',2''-(1,4,7-Triazonane-1,4,7-triyl)triacetic acid;NOTA(M-600);1,4,7-triazacyclononane-N,N',N''-triacetic acid;Octahydro-1H-1,4,7-triazonine-1,4,7-triacetic Acid;1H-1,4,7-Triazonine-1,4,7-triaceticacid, hexahydro-;1,4,7-triazacyclononane-N,N',N''-triacetic acid(NOTA);2-[4,7-bis(carboxymethyl)-1,4,7-triazonan-1-yl]acetic acid;2,2',2''-(1,4,7-triazacyclononane-1,4,7-triyl)triacetic acid;1H-1,4,7-Triazonine-1,4,7-triacetic acid, hexahydro-56491-86-2
- CBNumber:
- CB51387909
- Molecular Formula:
- C12H21N3O6
- Molecular Weight:
- 303.31
- MDL Number:
- MFCD00137938
- MOL File:
- 56491-86-2.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319 |
| Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 |
1,4,7-triazacyclononane-N,N',N''-triacetic acid price
1,4,7-triazacyclononane-N,N',N''-triacetic acid Chemical Properties,Uses,Production
Description
NOTA is a bifunctional chelating agent that shows high complexation constant with metals, such as gallium.
Uses
NOTA is a bifunctional chelate which acts as the framework to construct PET imaging tools. NOTA also can be used for probe design and signal amplification via the multivalent effect. NOTA can be used in multiple myeloma, breast cancer, lymphoma and myocardial infarction research[1][2][3][4][5][6].
in vivo
NOTA participates in the synthesis of [64Cu]NOTA-pentixather to enables high resolution PET imaging of CXCR4 expressionin in Daudi lymphoma-bearing severe combined immunodeficiency (SCID) mice [3].
NOTA participates in the synthesis of 68Ga-NOTA-RGD for MicroPET/CT imaging of αvβ3integrin in rat myocardial infarction[4].
NOTA participates in the synthesis of [68Ga]Ga-NOTA-Nb1053 for immunoPET imaging of multiple myeloma[5].
NOTA is a superior chelator to DOTA for PET imaging with 64Cu-labeled TRC105 in 4T1 murine breast tumor-bearing mice[6].
IC 50
RDC Bifunctional Chelator
References
[1] Singh AN, et al. Multivalent bifunctional chelator scaffolds for gallium-68 based positron emission tomography imaging probe design: signal amplification via multivalency. Bioconjug Chem. 2011;22(8):1650-1662. DOI:10.1021/bc200227d
[2] Liao AH, et al. Evaluation of 18F-labeled targeted perfluorocarbon-filled albumin microbubbles as a probe for microUS and microPET in tumor-bearing mice. Ultrasonics. 2013;53(2):320-327. DOI:10.1016/j.ultras.2012.06.014
[3] Poschenrieder A, et al. [64Cu]NOTA-pentixather enables high resolution PET imaging of CXCR4 expression in a preclinical lymphoma model. EJNMMI Radiopharm Chem. 2017;2(1):2. DOI:10.1186/s41181-016-0020-6
[4] Menichetti L, et al. MicroPET/CT imaging of αvβ? integrin via a novel ??Ga-NOTA-RGD peptidomimetic conjugate in rat myocardial infarction. Eur J Nucl Med Mol Imaging. 2013 Aug;40(8):1265-74. DOI:10.1007/s00259-013-2432-9
[5] Wang C, et al. ImmunoPET imaging of multiple myeloma with [68Ga]Ga-NOTA-Nb1053. Eur J Nucl Med Mol Imaging. 2021 Aug;48(9):2749-2760. DOI:10.1007/s00259-021-05218-1
[6] Zhang Y, et al. Positron emission tomography imaging of CD105 expression with a 64Cu-labeled monoclonal antibody: NOTA is superior to DOTA. PLoS One. 2011;6(12):e28005. DOI:10.1371/journal.pone.0028005
1,4,7-triazacyclononane-N,N',N''-triacetic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10406 | 58 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 8497 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29808 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| Chemsigma International Co., Ltd. | +86-2558742998 +86-19951791336 | info@chemsigma.com | China | 1369 | 58 |
| Finetech Industry Limited | +86-27-87465837 +8618971612321 | info@finetechnology-ind.com | China | 9642 | 58 |
| Henan Alfa Chemical Co., Ltd | +8615838112936 | alfa10@alfachem.cn | China | 13194 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38630 | 58 | |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43340 | 58 |
View Lastest Price from 1,4,7-triazacyclononane-N,N',N''-triacetic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2024-10-28 | NOTA
56491-86-2
|
US $36.00 / mg | 10g | TargetMol Chemicals Inc. | |||
 |
2024-04-02 | NOTA
56491-86-2
|
US $0.00 / mg | 250mg | >95.00% | 250mg | Xian confluore Biological Technology Co., Ltd. | |
 |
2022-01-15 | 1,4,7-triazacyclononane-N,N',N''-triacetic acid
56491-86-2
|
US $0.00 / KG | 1KG | 98.5% | 100 tons | Honest Joy Holdings Limited
|
-
- NOTA
56491-86-2
- US $36.00 / mg
- TargetMol Chemicals Inc.
-
- NOTA
56491-86-2
- US $0.00 / mg
- >95.00%
- Xian confluore Biological Technology Co., Ltd.
-
- 1,4,7-triazacyclononane-N,N',N''-triacetic acid
56491-86-2
- US $0.00 / KG
- 98.5%
- Honest Joy Holdings Limited