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H3B-968

H3B-968 structure

CAS No.: 2912294-90-5

Chemical Name:: H3B-968

Synonyms: H3B-968;Acetamide, N-(4-ethylphenyl)-2-[[[4-[4-(trifluoromethoxy)phenyl]-6-(trifluoromethyl)-2-pyrimidinyl]sulfonyl]amino]-

CBNumber:: CB514259709

Molecular Formula:: C22H18F6N4O4S

Molecular Weight:: 548.46

MDL Number:

MOL File:: 2912294-90-5.mol

Last updated:2025-04-17 18:22:24

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H3B-968 Properties

Density	1.459±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
pka	8.608±0.10(predicted)
form	Solid
color	White to off-white

H3B-968 Chemical Properties,Uses,Production

Uses

H3B-968 is a potent inhibitor of Werner syndrome protein (WRN) (IC50=~10 nM)，which acts function as helicase，ATPase，and exonuclease. WRN exhibits synthetic lethal activity in cancer research. However，H3B-968 inhibits WRN helicase activity，competitively with ATP[1].

References

[1] Parker MJ, et al. Identification of 2-Sulfonyl/Sulfonamide Pyrimidines as Covalent Inhibitors of WRN Using a Multiplexed High-Throughput Screening Assay. Biochemistry. 2023 Jul 18;62(14):2147-2160. DOI:10.1021/acs.biochem.2c00599

H3B-968 Preparation Products And Raw materials

Raw materials

Preparation Products

H3B-968 Suppliers

Global( 2)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	+8613564774135	zijue.cai@tsbiochem.com	United States	19881	58
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	19699	58

Supplier	Advantage
TargetMol Chemicals Inc.	58
TargetMol Chemicals Inc.	58

View Lastest Price from H3B-968 manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2024-10-28	H3B-968 2912294-90-5	US $0.00-0.00 / mg			10g	TargetMol Chemicals Inc.

H3B-968
2912294-90-5
US $0.00-0.00 / mg
TargetMol Chemicals Inc.

H3B-968 Acetamide, N-(4-ethylphenyl)-2-[[[4-[4-(trifluoromethoxy)phenyl]-6-(trifluoromethyl)-2-pyrimidinyl]sulfonyl]amino]- 2912294-90-5