mG2N001
- CAS No.
- 2760515-88-4
- Chemical Name:
- mG2N001
- Synonyms
- mG2N001;2H-Pyrano[2,3-b]pyridine-7-carboxamide, 5-(2-fluoro-4-methoxyphenyl)-3,4-dihydro-2,2-dimethyl-
- CBNumber:
- CB514274917
- Molecular Formula:
- C18H19FN2O3
- Molecular Weight:
- 330.35
- MDL Number:
- MOL File:
- 2760515-88-4.mol
mG2N001 Chemical Properties,Uses,Production
Uses
mG2N001 is a negative allosteric modulator (NAM) (IC50: 93 nM) of the metabotropic glutamate receptor mGluR2 and binds to mGluR2 as an antagonist (Ki: 63 nM). mG2N001 is microparticle- and plasma-stable, and its radioisotope [11C]mG2N001 can be used in PET imaging. [11C]mG2N001 has good brain heterogeneity and brain penetration, and can selectively accumulate in mGluR2-rich regions, producing high-contrast brain images[1].
in vivo
mG2N001 (63.0-87.3 MBq [11C]mG2N001, iv.) can perform PET imaging experiments in rats and cynomolgus monkeys, showing the specific binding activity of mGluR2, clearly showing the binding activity of mGluR2 in the animal brain Biological distribution map[1].
References
[1] Yuan G, et al. Synthesis and Characterization of 5-(2-Fluoro-4-[11C]methoxyphenyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide as a PET Imaging Ligand for Metabotropic Glutamate Receptor 2. J Med Chem. 2022 Feb 10;65(3):2593-2609. DOI:10.1021/acs.jmedchem.1c02004
mG2N001 Preparation Products And Raw materials
Raw materials
Preparation Products
mG2N001 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Beckham Medical Technology Co., Ltd | 021-13816613772 13816613772 | huahero21@sina.com | China | 959 | 55 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 19699 | 58 |
| Supplier | Advantage |
|---|---|
| Shanghai Beckham Medical Technology Co., Ltd | 55 |
| TargetMol Chemicals Inc. | 58 |