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N-Cbz-Hydroxy-L-proline

N-Cbz-Hydroxy-L-proline structure

CAS No.: 13504-85-3

Chemical Name:: N-Cbz-Hydroxy-L-proline

Synonyms: CBZ-L-HYDROXYPROLINE;(2S,4R)-1-((benzyloxy)carbonyl)-4-hydroxypyrrolidine-2-carboxylic acid;Z-HYP-OH;CBZ-HYP-OH;Z-Hyp;Z-L-HYP-OH;CBZ-L-HYP-OH;-4-hydroxy-L;Z-HYP(BZL)-OH;Z-HYDROXYPROLINE

CBNumber:: CB5148552

Molecular Formula:: C13H15NO5

Molecular Weight:: 265.26

MDL Number:: MFCD00037329

MOL File:: 13504-85-3.mol

MSDS File:: SDS

Last updated:2024-04-28 16:56:32

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N-Cbz-Hydroxy-L-proline Properties

Melting point	104-107 °C
Boiling point	486.9±45.0 °C(Predicted)
Density	1.416±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	Dichloromethane, Ethyl Acetate
form	Oil
pka	3.78±0.40(Predicted)
optical activity	[α]20/D 54±1°, c = 2% in ethanol
Water Solubility	Slightly soluble in water.
BRN	90295
CAS DataBase Reference	13504-85-3(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P

WGK Germany

HS Code

29339900

NFPA 704

	1
0		0

N-Cbz-Hydroxy-L-proline price More Price(46)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	96310	Z-Hyp-OH ≥99.0% (T)	13504-85-3	25g	$138	2024-03-01	Buy
Sigma-Aldrich	96310	Z-Hyp-OH ≥99.0% (T)	13504-85-3	5g	$79	2023-06-20	Buy
TCI Chemical	C2506	trans-N-Carbobenzoxy-4-hydroxy-L-proline >98.0%(HPLC)(T)	13504-85-3	5g	$27	2024-03-01	Buy
TCI Chemical	C2506	trans-N-Carbobenzoxy-4-hydroxy-L-proline >98.0%(HPLC)(T)	13504-85-3	25g	$137	2024-03-01	Buy
Alfa Aesar	H59882	N-Benzyloxycarbonyl-4-hydroxy-L-proline, 99%	13504-85-3	25g	$173	2021-12-16	Buy

Product number	Packaging	Price	Buy
96310	25g	$138	Buy
96310	5g	$79	Buy
C2506	5g	$27	Buy
C2506	25g	$137	Buy
H59882	25g	$173	Buy

N-Cbz-Hydroxy-L-proline Chemical Properties,Uses,Production

Chemical Properties

Viscous Oil

Uses

A competitive inhibitor of porcine kidney prolidase.

N-Cbz-Hydroxy-L-proline synthesis

Synthesis of N-Cbz-Hydroxy-L-proline from Benzyl chloroformate and cis-4-Hydroxy-D-proline

N-Cbz-Hydroxy-L-proline Preparation Products And Raw materials

Raw materials

Preparation Products

2-PyrrolidineMethanol, 4-hydroxy-, hydrochloride (1:1), (2S,4R)- N-BOC-cis-4-fluoro-L-proline (2S,4R)-1-((benzyloxy)carbonyl)-4-methoxypyrrolidine-2-carboxylic acid Z-TRANS-4-HYDROXY-L-PROLINOL

N-Cbz-Hydroxy-L-proline Suppliers

Global( 332)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Mojin Biotechnology Co., Ltd	+86 13288715578 +8613288715578	sales@hbmojin.com	China	12839	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29791	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32957	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29882	58
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	17322	58
Hebei Weibang Biotechnology Co., Ltd	+8615531157085	abby@weibangbio.com	China	8811	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22963	58
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	sales@chemdad.com	China	39894	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49374	58
Fuxin Pharmaceutical	+86-021-021-50872116 +8613122107989	contact@fuxinpharm.com	China	10032	58

Supplier	Advantage
Hebei Mojin Biotechnology Co., Ltd	58
Capot Chemical Co.,Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Accela ChemBio Inc.	58
Hebei Weibang Biotechnology Co., Ltd	58
Hubei xin bonus chemical co. LTD	58
Chongqing Chemdad Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
Fuxin Pharmaceutical	58

View Lastest Price from N-Cbz-Hydroxy-L-proline manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-04-28	Z-Hyp-OH 13504-85-3	US $5.00 / kg	1kg	99.92%	50000tons	Ouhuang Engineering Materials (Hubei) Co., Ltd
2023-08-16	N-Cbz-Hydroxy-L-proline 13504-85-3	US $0.00 / KG	1KG	99%	50000KG/month	Hebei Mojin Biotechnology Co., Ltd
2022-01-26	Z-Hyp-oh 13504-85-3	US $0.00 / KG	1KG	98.3%	100 tons	Honest Joy Holdings Limited

Z-Hyp-OH
13504-85-3
US $5.00 / kg
99.92%
Ouhuang Engineering Materials (Hubei) Co., Ltd

N-Cbz-Hydroxy-L-proline
13504-85-3
US $0.00 / KG
99%
Hebei Mojin Biotechnology Co., Ltd

Z-Hyp-oh
13504-85-3
US $0.00 / KG
98.3%
Honest Joy Holdings Limited

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N-CARBOBENZOXY-L-ISOLEUCINE DICYCLOHEXYLAMMONIUM SALT Z-TRANS-4-HYDROXY-L-PROLINOL Z-Hyp(tBu)-OMe Cbz-N-methyl-L-phenylalanine Z-ARG(NO2)-OH

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1of4

N-carbobenzyloxy-4-hydroxy-l-proline 1-(benzyloxycarbonyl)-4-hydroxy-proline 4-hydroxy-1-(phenylmethoxycarbonyl)pyrrolidine-2-carboxylic acid N-Cbz-Hydroxy-L-prol (2S,4R)-4-Hydroxypyrrolidine-2-carboxylic acid, N-CBZ protected trans-4-Hydroxy-L-proline, N-CBZ protected 1,2-Pyrrolidinedicarboxylic acid, 4-hydroxy-, 1-(phenylMethyl) ester, (2S,4R)- trans-N-Carbobenzoxy-4-hydroxy-L-proline trans-N-Cbz-4-hydroxy-L-proline Z-Hyp-OH (2S,4R)-4-Hydroxy-1,2-pyrrolidinedicarboxylic Acid 1-Benzyl Ester N-CBZ-4-hydroxy-L-proline Z-Hyp-OH >=99.0% (T) Z-L-4-trans-hydroxyproline≥ 98% (HPLC) N-Cbz-cis-4-hydroxy-D-proline (2R,4R)-N-CBZ-4-HYDROXY-D-PROLINE Cbz-L-4- Hydroxyproline N-Benzyloxycarbonyl-4-hydroxy-L-proline N-Benzyloxycarbonyl-L-Hydroproline N-CARBOBENZYLOXY-TRANS-4-HYDROXY-L-PROLINE N-CBZ-CIS-4-HYDROXY-L-PROLINE CBZ-TRANS-4-HYDROXY-L-PROLINE Z-L-HYDROXYPROLINE extrapure N-carbobenzyloxy-hydroxy-L-proline N-Cbz-Hydroxy-L-proline, Z-L-4-Hydroxyproline (2S)-1-(Benzyloxycarbonyl)-4β-hydroxypyrrolidine-2α-carboxylic acid (2S,4R)-4-Hydroxy-1,2-pyrrolidinedicarboxylic acid hydrogen 1-(phenylmethyl) ester (4R)-1-(Benzyloxycarbonyl)-4-hydroxy-L-proline (4R)-N-(Benzyloxycarbonyl)-4-hydroxy-L-proline 1-(Benzyloxycarbonyl)-trans-4-hydroxy-L-proline N-(Benzyloxycarbonyl)-trans-4-hydroxy-L-proline N-ALPHA-CARBOBENZOXY-L-HYDROXYPROLINE N-ALPHA-CARBOBENZOXY-O-BENZYL-TRANS-4-HYDROXY-L-PROLINE N-ALPHA-CBZ-L-4-TRANS-HYDROXYPROLINE N-ALPHA-BENZYLOXYCARBONYL-TRANS-L-HYDROXYPROLINE N-ALPHA-CARBOBENZOXY-(2S,4R)-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID N-CARBOBENZOXY-L-HYDROXYPROLINE N-CBZ-HYDROXY-L-PROLINE Z-4-HYDROXY-L-PROLINE Z-HYP(BZL)-OH Z-HYDROXYPROLINE Z-L-HYDROXYPROLINE Z-L-HYP-OH Z-L-4-HYDROXYPROLINE Z-L-4-TRANS-HYDROXYPROLINE TRANS-N-ALPHA-BENZYLOXYCARBONYL-L-HYDROXYPROLINE BENZYLOXYCARBONYL-L-4-HYDROXYPROLINE CBZ-L-HYP-OH N-Carbobenzyloxy-4-hydroxy-L-proline (trans) N-Z-4-hydroxy-L-proline (trans) 1-benzyl hydrogen (2S-trans)-4-hydroxypyrrolidine-1,2-dicarboxylate Z-trans-4-hydroxy-L-proline Z-Hyp (2R)-2-hydroxy-1-phenylmethoxycarbonyl-2-pyrrolidinecarboxylic acid (2S,4R)-N-Cbz-trans-4-hydroxy-L-proline Z-Hyp-OH (Non-Animal Origiated Hyp) N-Carbobenzoxy-4-hydroxy-L-proline trans-N-Cbz-4-hydroxy-L-proline, 98% trans-N-Carbobenzoxy-4-hydroxy-L-proline >