3-(Benzyloxy)propan-1-amine
- CAS No.
- 16728-64-6
- Chemical Name:
- 3-(Benzyloxy)propan-1-amine
- Synonyms
- 3-benzyloxy-propylaMine;3-Benzyloxypropane-1-amine;3-(Benzyloxy)propan-1-amine;3-(benzyloxy)-1-propanamine;1-Amino-3-(benzyloxy)propane;3-phenylmethoxypropan-1-amine;3-(BENZYLOXY)PROPAN-1-AMINE 97%;4-Benzofuranpropanenitrile,β-oxo-;1-Propanamine, 3-(phenylmethoxy)-;[3-(benzyloxy)propyl]amine hydrochloride
- CBNumber:
- CB51497042
- Molecular Formula:
- C10H15NO
- Molecular Weight:
- 165.23
- MDL Number:
- MFCD07339550
- MOL File:
- 16728-64-6.mol
- MSDS File:
- SDS
| Boiling point | 103 °C(Press: 2 Torr) |
|---|---|
| Density | 0.999±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C(protect from light) |
| pka | 9.74±0.10(Predicted) |
| Comptox DTXSID | DTXSID70427866 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H319 |
| Precautionary statements | P305+P351+P338 |
| HS Code | 2922199090 |
3-(Benzyloxy)propan-1-amine price More Price(52)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Activate Scientific | AS42717 | 3-(Benzyloxy)propan-1-amine 97% | 16728-64-6 | 1g | $281 | 2026-06-04 | Buy |
| Activate Scientific | AS42717 | 3-(Benzyloxy)propan-1-amine 97% | 16728-64-6 | 5g | $845 | 2026-06-04 | Buy |
| Matrix Scientific | 301461 | 3-(Benzyloxy)propan-1-amine | 16728-64-6 | 250.00mg | $86 | 2026-05-19 | Buy |
| Matrix Scientific | 301461 | 3-(Benzyloxy)propan-1-amine | 16728-64-6 | 1.00g | $171 | 2026-05-19 | Buy |
| Matrix Scientific | 301461 | 3-(Benzyloxy)propan-1-amine | 16728-64-6 | 5.00g | $556 | 2026-05-19 | Buy |
3-(Benzyloxy)propan-1-amine Chemical Properties, Uses, Production
Synthesis Reference(s)
Synthesis, p. 590, 1975 DOI: 10.1055/s-1975-23843
Synthesis
100-39-0
156-87-6
16728-64-6
A 60% sodium hydride dispersion (4 g, 0.1 mol) was slowly added to a stirred solution of 3-amino-1-propanol (7.51 g, 0.1 mol) in tetrahydrofuran (THF, 150 mL) at room temperature. The reaction mixture was stirred under nitrogen protection for 30 min before benzyl bromide (11.9 mL, 0.1 mol) was added. The reaction was continued to be stirred at room temperature for 10 hours, followed by vacuum concentration. The concentrated residue was partitioned between a 1N aqueous hydrochloric acid solution and dichloromethane (CH2Cl2). The aqueous layer was adjusted to pH 10 with 10% aqueous sodium hydroxide and subsequently extracted with dichloromethane (3 x 100 mL). The organic phases were combined, dried with magnesium sulfate (MgSO4) and concentrated in vacuum. The residue was purified by silica gel column chromatography using dichloromethane/methanol (3:1 to 2:1, v/v) as eluent to give 3-(benzyloxy)propylamine (8.3% yield) as a yellow oil. A solution of 1,3-dicyclohexylcarbodiimide (14.4 mg, 0.07 mmol) in dichloromethane (2 mL) was added dropwise to a solution of compound 5 (32 mg, 0.07 mmol), 3-(benzyloxy)propylamine (0.07 mmol), and 1-hydroxybenzotriazole hydrate (9.5 mg, 0.07 mmol) in dichloromethane (5 mL) at 0°C . The reaction mixture was stirred at room temperature for 18 h and then concentrated under vacuum. The residue was purified by silica gel column chromatography using dichloromethane/methanol (30:1, v/v) as eluent to afford compound 8 (36 mg, 85% yield) as a light yellow liquid.1H NMR (CDCl3) δ 8.05 (s, 1H, H4), 7.44 (d, 1H, H5, J = 8.7Hz), 7.19-7.28 (m, 11H H6 + 2 × OCH2Ph), 6.78-6.82 (m, 3H, H2' + H5' + H6'), 6.06 (AB, 2H, 3',4'-OCH2O-, J = 6.9 Hz, J = 1.5 Hz), 5.84 (AB, 2H, 7,8-OCH2O-, J = 4.2 Hz, J = 1.5 Hz), 4.45 (s 4H, 2 × OCH2Ph), 4.38 (s, 2H, 2-CH2OBn), 3.55 (m, 4H, 3-CONHCH2CH2CH2OBn), 1.87 (quintuple peak, 2H, 3-CONHCH2CH2CH2OBn, J = 6.3 Hz); MS (FAB, positive) m/z 604 [M + H]+.
References
[1] Journal of Medicinal Chemistry, 2005, vol. 48, # 2, p. 534 - 546
[2] Patent: WO2005/107742, 2005, A1. Location in patent: Page/Page column 40-41
3-(Benzyloxy)propan-1-amine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shandong Xiya Chemical Co., Ltd | 13355009207 13355009207 | 3007715519@qq.com | China | 18722 | 57 |
| skychemical Co.Ltd | 021-20958197 20965099 | sales@skychemical.com | China | 1182 | 57 |
| SynAsst Chemical. | 021-60343070 | China | 12731 | 55 | |
| Amatek Scientific Co. Ltd. | 0512-56316828 4008675858 | sales@amateksci.com | China | 9842 | 55 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Hangzhou J&H Chemical Co., Ltd. | 0571-87396432 | sales@jhechem.com | China | 14876 | 59 |
| Shanghai HuanChuan Industry Co.,Ltd. | 021-61478794 | sales@hcshhai.com | China | 9781 | 50 |
| Cool Pharm, Ltd | 021-60455363 18019463053 | sales@coolpharm.com | China | 8455 | 58 |
| Shanghai KunRaise Chemical Technology Co., Ltd | +86-021-50935922 | China | 715 | 55 | |
| DebyeTec.com Inc. | 18086626237 18086626237 | 2693528373@qq.com | China | 2972 | 56 |
View Latest Price from 3-(Benzyloxy)propan-1-amine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-07-06 | 3-benzyloxypropylamine
16728-64-6
|
$1.00 | 1KG | 98% | 200kg | Career Henan Chemical Co |
-
- 3-benzyloxypropylamine
16728-64-6
- $1.00
- 98%
- Career Henan Chemical Co
