Tozasertib
- CAS No.
- 639089-54-6
- Chemical Name:
- Tozasertib
- Synonyms
- VE465;VX 680;VX-860;CS-176;VE 465;VE-465;MK 0457;Tozasertib;L-001281814;VX-680/MK-0457
- CBNumber:
- CB51513746
- Molecular Formula:
- C23H28N8OS
- Molecular Weight:
- 464.59
- MDL Number:
- MFCD13185152
- MOL File:
- 639089-54-6.mol
Melting point | 248-253°C (dec.) |
---|---|
Density | 1.40±0.1 g/cm3(Predicted) |
storage temp. | 2-8°C |
solubility | Soluble in DMSO (up to 100 mg/ml). |
pka | 14.09±0.70(Predicted) |
form | powder |
color | white to beige |
Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
FDA UNII | 234335M86K |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H302 |
Precautionary statements | P280-P305+P351+P338 |
Tozasertib price More Price(36)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | SML2158 | VX-680 ≥98% (HPLC) | 639089-54-6 | 10mg | $76 | 2024-03-01 | Buy |
Cayman Chemical | 13600 | MK-0457 ≥98% | 639089-54-6 | 25mg | $86 | 2024-03-01 | Buy |
Cayman Chemical | 13600 | MK-0457 ≥98% | 639089-54-6 | 50mg | $161 | 2024-03-01 | Buy |
Cayman Chemical | 13600 | MK-0457 ≥98% | 639089-54-6 | 100mg | $302 | 2024-03-01 | Buy |
Cayman Chemical | 13600 | MK-0457 ≥98% | 639089-54-6 | 250mg | $546 | 2024-03-01 | Buy |
Tozasertib Chemical Properties,Uses,Production
Description
The Aurora kinases (A, B, and C) are a family of serine-
Chemical Properties
White Solid
Uses
Tozasertib is used as a multikinase inhibitor once used for cancer treatment.
Definition
ChEBI: N-[4-[[4-(4-methyl-1-piperazinyl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyrimidinyl]thio]phenyl]cyclopropanecarboxamide is a N-arylpiperazine.
Biochem/physiol Actions
VX-680 is an ATP site-targeting potent aurora kinase inhibitor (Aurara A/B/C Ki(app) = 0.6/18/4.6 nM) that affects FLT3, BCR-Abl, BCR-Abl (T315I), Lck, ITK, Src, and Fyn only at higher concentrations (Ki(app) = 30, 30, 42, 80, 220, 350, 520 nM, respectively) and exhibits little inhibitory potency toward 52 other kinases (Ki(app) >1 μM). VX-680 exhibits potent antiproliferation activity in a wide variety of cancer cultures (IC50 from 15 to 113 nM) as a result of cell cycle arrest and apoptosis induction, as well as causes tumor retardation (by 98% on day 13; 75 mg/kg b.i.d i.p.; HL-60 in mice) and regression (2 mg/kg/h 3 d/wk i.v. infusion; HCT116 in rats) in vivo. Crystallography data reveal a tight association of VX-680 with a hydrophobic pocket present only in a closed, inactive kinase conformation, which forms the basis of its selectivity profile, including its activity toward wild-type and the Imatinib-resistant (T315I) Abl.
References
1) Harrington et al. (2004), VX-680, a potent and selective small molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo; Nat. Med., 10 262 2) Fei et al. (2010), Activity of the Aurora kinase inhibitor VX-680 against Bcr/Abl-positive acute lymphoblastic leukemias; Mol. Cancer Ther., 9 1318 3) Dewerth et al. (2012), In vitro evaluation of the Aurora kinase inhibitor VX-680 for Hepatoblastoma; Pediatr. Surg. Int., 28 579
Tozasertib Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29798 | 60 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32836 | 60 |
Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49392 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29821 | 58 |
SIMAGCHEM CORP | +86-13806087780 | sale@simagchem.com | China | 17367 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23555 | 58 |
Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 23699 | 58 |
View Lastest Price from Tozasertib manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2019-12-23 | Tozasertib
639089-54-6
|
US $1.00 / g | 100g | 99% | G/KG/T | Career Henan Chemical Co |
- Tozasertib
639089-54-6
- US $1.00 / g
- 99%
- Career Henan Chemical Co