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ChemicalBook >> CAS DataBase List >>6-[4-(1H-IMIDAZOL-1-YL)PHENOXY]-N,N-DIMETHYL-1-HEXANAMINE, DIHYDROCHLORIDE

6-[4-(1H-IMIDAZOL-1-YL)PHENOXY]-N,N-DIMETHYL-1-HEXANAMINE, DIHYDROCHLORIDE

6-[4-(1H-IMIDAZOL-1-YL)PHENOXY]-N,N-DIMETHYL-1-HEXANAMINE, DIHYDROCHLORIDE Structure
6-[4-(1H-IMIDAZOL-1-YL)PHENOXY]-N,N-DIMETHYL-1-HEXANAMINE, DIHYDROCHLORIDE structure
CAS No.
502656-68-0
Chemical Name:
6-[4-(1H-IMIDAZOL-1-YL)PHENOXY]-N,N-DIMETHYL-1-HEXANAMINE, DIHYDROCHLORIDE
Synonyms
CAY10462;CAY10462 2HCl;CAY 10462 dihydrochloride;6-(4-imidazol-1-ylphenoxy)-N,N-dimethylhexan-1-amine:dihydrochloride;6-[4-(1H-IMIDAZOL-1-YL)PHENOXY]-N,N-DIMETHYL-1-HEXANAMINE, DIHYDROCHLORIDE
CBNumber:
CB5194610
Molecular Formula:
C17H27Cl2N3O
Molecular Weight:
360.32
MDL Number:
MFCD08062176
MOL File:
Mol file
Last updated:2024-07-02 08:55:11
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6-[4-(1H-IMIDAZOL-1-YL)PHENOXY]-N,N-DIMETHYL-1-HEXANAMINE, DIHYDROCHLORIDE Properties

solubility DMSO: 15 mg/ml; Ethanol: 10 mg/ml; PBS (pH 7.2): 10 mg/ml
form A crystalline solid
color Off-white to light yellow

6-[4-(1H-IMIDAZOL-1-YL)PHENOXY]-N,N-DIMETHYL-1-HEXANAMINE, DIHYDROCHLORIDE price More Price(6)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 10006400 CAY10462 ≥98% 502656-68-0 1mg $25 2024-03-01 Buy
Cayman Chemical 10006400 CAY10462 ≥98% 502656-68-0 5mg $107 2024-03-01 Buy
Cayman Chemical 10006400 CAY10462 ≥98% 502656-68-0 10mg $186 2024-03-01 Buy
Cayman Chemical 10006400 CAY10462 ≥98% 502656-68-0 50mg $807 2024-03-01 Buy
AK Scientific 1480AH 6-[4-(1H-Imidazol-1-yl)phenoxy]-n,n-dimethyl-1-hexanamine,dihydrochloride 502656-68-0 50mg $997 2021-12-16 Buy
Product number Packaging Price Buy
10006400 1mg $25 Buy
10006400 5mg $107 Buy
10006400 10mg $186 Buy
10006400 50mg $807 Buy
1480AH 50mg $997 Buy

6-[4-(1H-IMIDAZOL-1-YL)PHENOXY]-N,N-DIMETHYL-1-HEXANAMINE, DIHYDROCHLORIDE Chemical Properties,Uses,Production

Description

20-HETE is an important metabolite of arachidonic acid in the vasculature, especially in the kidney, where it is synthesized by cytochrome P450 (CYP450) enzymes of the 4A family.1,2 Alkylaryl imidazoles have been shown to inhibit certain CYP450 enzymes, including the CYP4A enzymes associated with 20-HETE synthesis.3 CAY10462 is the hydrochloride salt of CAY10434 and selective inhibitor of the 20-HETE synthase CYP4A11 exhibiting an IC50 of 8.8 nM when tested in human renal microsomes.4 CAY10434 is nearly 200 times less potent as an inhibitor of 1A, 1C, and 3A CYP450 enzymes.

References

1. Harder, D.R., Lange, A.R., Gebremedhin, D., et al. Cytochrome P450 metabolites of arachidonic acid as intracellular signaling molecules in vascular tissue J. Vasc. Res. 34,237-243(1997).
2. Imig, J.D., Zou, A.P., Stec, D.E., et al. Formation and actions of 20-hydroxyeicosatetraenoic acid in rat renal arterioles Am. J. Physiol. 270,R217-R227(1996).
3. Nakamura, T., Kakinuma, H., Umemiya, H., et al. Imidazole derivatives as new potent and selective 20-HETE synthase inhibitor Bioorg. Med. Chem. Lett. 14,333-336(2004).

6-[4-(1H-IMIDAZOL-1-YL)PHENOXY]-N,N-DIMETHYL-1-HEXANAMINE, DIHYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

6-[4-(1H-IMIDAZOL-1-YL)PHENOXY]-N,N-DIMETHYL-1-HEXANAMINE, DIHYDROCHLORIDE Suppliers

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ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32760 60
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ATK CHEMICAL COMPANY LIMITED 		60
Chemtour Biotech Co., Ltd 		58
BOC Sciences 65
ShangHai Biochempartner Co.,Ltd 62
Shanghai Chaolan Chemical Technology Center 58
Shanghai Hongye Biotechnology Co. Ltd 58
DC Chemicals 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
Suzhou Chenrui Biotechnology Co. LTD 58
TargetMol Chemicals Inc. 58

502656-68-0(6-[4-(1H-IMIDAZOL-1-YL)PHENOXY]-N,N-DIMETHYL-1-HEXANAMINE, DIHYDROCHLORIDE)Related Search:

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6-[4-(1H-IMIDAZOL-1-YL)PHENOXY]-N,N-DIMETHYL-1-HEXANAMINE, DIHYDROCHLORIDE CAY10462 6-(4-imidazol-1-ylphenoxy)-N,N-dimethylhexan-1-amine:dihydrochloride CAY10462 2HCl CAY 10462 dihydrochloride 502656-68-0