2,2'-Dithiodipyridine
- CAS No.
- 2127-03-9
- Chemical Name:
- 2,2'-Dithiodipyridine
- Synonyms
- 1,2-Di(pyridin-2-yl)disulfane;Aldrithiol;2-Aldrithiol;2-PDS;Dithiodipyridine;ALDRITHIOL-2;Dipyridyldisulfide;2-Pyridyl disulfide;2,2'-DIPYRIDYL DISULFIDE;1,2-Bis(2-pyridinyl) Disulfide
- CBNumber:
- CB5200205
- Molecular Formula:
- C10H8N2S2
- Molecular Weight:
- 220.31
- MDL Number:
- MFCD00006287
- MOL File:
- 2127-03-9.mol
- MSDS File:
- SDS
Melting point | 56-58 °C(lit.) |
---|---|
Boiling point | 356.1±17.0 °C(Predicted) |
Density | 1.3078 (rough estimate) |
refractive index | 1.5500 (estimate) |
Flash point | 210 °C |
storage temp. | 2-8°C |
solubility | methanol: soluble50mg/mL, clear to very slightly hazy, colorless to faintly brownish-yellow |
pka | 1.52±0.19(Predicted) |
form | powder |
color | Clear colorless to yellow to tan |
Water Solubility | 5 g/L (20 ºC) |
BRN | 154629 |
InChIKey | HAXFWIACAGNFHA-UHFFFAOYSA-N |
LogP | 2.530 (est) |
CAS DataBase Reference | 2127-03-9(CAS DataBase Reference) |
FDA UNII | L6X912UPBU |
NIST Chemistry Reference | Pyridine, 2,2'-dithiobis-(2127-03-9) |
EPA Substance Registry System | Pyridine, 2,2'-dithiobis- (2127-03-9) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
|||||||||
---|---|---|---|---|---|---|---|---|---|---|
Signal word | Warning | |||||||||
Hazard statements | H315-H319-H335 | |||||||||
Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
Hazard Codes | Xi,Xn | |||||||||
Risk Statements | 36/37/38-37-20/22 | |||||||||
Safety Statements | 36/37/39-37/39-25-22-36-26 | |||||||||
RIDADR | UN 3335 | |||||||||
WGK Germany | 3 | |||||||||
F | 10-23 | |||||||||
Autoignition Temperature | 340 °C | |||||||||
Hazard Note | Irritant | |||||||||
TSCA | Yes | |||||||||
HS Code | 29333990 | |||||||||
NFPA 704 |
|
2,2'-Dithiodipyridine price More Price(54)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | 143049 | Aldrithiol?-2 98% | 2127-03-9 | 1g | $67.2 | 2024-03-01 | Buy |
Sigma-Aldrich | 8.41109 | 2,2′-Dipyridyl disulfide for synthesis | 2127-03-9 | 5G | $129 | 2024-03-01 | Buy |
Sigma-Aldrich | 143049 | Aldrithiol?-2 98% | 2127-03-9 | 5g | $128 | 2024-03-01 | Buy |
TCI Chemical | D1114 | 2,2'-Dipyridyl Disulfide [for Peptide Synthesis] >98.0%(GC)(T) | 2127-03-9 | 5g | $54 | 2024-03-01 | Buy |
TCI Chemical | D1114 | 2,2'-Dipyridyl Disulfide [for Peptide Synthesis] >98.0%(GC)(T) | 2127-03-9 | 25g | $162 | 2024-03-01 | Buy |
2,2'-Dithiodipyridine Chemical Properties,Uses,Production
Chemical Properties
white to yellowish crystalline powder
Uses
2,2'-Dipyridyl disulfide is a useful reagent for determination of sulfhydryl groups, preparation of amino acid active esters and the thio esters of phosphoric acid. It acts as a peptide coupling reagent and as an oxidizing agent. It is also used for the activation of glycosides.
Uses
2,2'-Dipyridyldisulfide, sometimes known as DPS, is used for preparing thiols and activating or protecting carboxylic acid with triphenylphosphine.
Uses
2,2'-Dithiodipyridine was used in the synthesis of adenosine-5′-phosphoimidazolide. It was employed with PPh3 as a condensing agent in the amidation of carboxylic acid enantiomers for HPLC separation.
Definition
ChEBI: Aldrithiol is a member of the class of pyridines that is pyridine which is substituted by a pyridin-2-yldisulfanediyl group at position 2. It is a reagent used in molecular biology as an oxidizing agent. Also used in peptide synthesis and for detecting thiols. It has a role as an oxidising agent. It is an organic disulfide and a member of pyridines.
General Description
2,2'-Dithiodipyridine is a nucleocapsid zinc finger targeting compound and can abrogate the infectivity of human immunodeficiency virus type-1 virions. It is a thiol reagent.
Biochem/physiol Actions
2,2′-Dithiodipyridine mediates inter-unit disulfide cross-linking. It interacts with carbon nucleophiles to yield thiopyridyl derivatives.
Purification Methods
Recrystallise the disulfide H2O from *C6H6/pet ether (6:7), ligroin or *C6H6. The picrate has m 119o (from EtOH). [Walter et al. Justus Liebigs Ann Chem 695 7785 1966, Marckwald et al. Chem Ber 33 1556 1900, Brocklehurst & Little Biochem J 133 67,78 1973, Beilstein 21 III/IV 48.] It has been used as a 1mM solution in EtOH for the spectrophotometric estimation of thiols. Essentially the thiol displaces half the disulfide molecule liberating the 2-mercaptopyridine anion, thereby shifting the from 340nm (of the disulfide) to 268nm (of the anion) at pH 9, or 278nm in H2O. (Compare
2,2'-Dithiodipyridine Preparation Products And Raw materials
Raw materials
Preparation Products
1of2
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39916 | 58 |
Shijiazhuang Jianxin Biotechnology Co., LTD | +undefined86-19062313169 | liyingjian1997@gmail.com | China | 710 | 58 |
Hebei Yanxi Chemical Co., Ltd. | +86-17531190177; +8617531190177 | peter@yan-xi.com | China | 5873 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29798 | 60 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21668 | 55 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32760 | 60 |
Zjartschem | +86-571 87238903 | jocelynpan@zjarts.com | CHINA | 993 | 58 |
Shanxi Naipu Import and Export Co.,Ltd | +86-13734021967 +8613734021967 | kaia@neputrading.com | China | 1011 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29894 | 58 |
SHANDONG ZHI SHANG CHEMICAL CO.LTD | +86 18953170293 | sales@sdzschem.com | China | 2931 | 58 |
View Lastest Price from 2,2'-Dithiodipyridine manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
![]() |
2024-08-20 | 2,2'-Dithiodipyridine
2127-03-9
|
US $0.00 / GK | 1GK | 98% | 1-10mt | Baoji Guokang Bio-Technology Co., Ltd. | |
![]() |
2024-08-15 | 2,2'-Dithiodipyridine
2127-03-9
|
US $500.00 / KG | 1KG | 98% | 500KG/Month | Hebei Yanxi Chemical Co., Ltd. | |
![]() |
2024-07-18 | 2,2'-Dithiodipyridine
2127-03-9
|
US $300.00-200.00 / KG | 1KG | 99%+ | 5000KG/Month | Shijiazhuang Jianxin Biotechnology Co., LTD |
-
- 2,2'-Dithiodipyridine
2127-03-9
- US $0.00 / GK
- 98%
- Baoji Guokang Bio-Technology Co., Ltd.
-
- 2,2'-Dithiodipyridine
2127-03-9
- US $500.00 / KG
- 98%
- Hebei Yanxi Chemical Co., Ltd.
-
- 2,2'-Dithiodipyridine
2127-03-9
- US $300.00-200.00 / KG
- 99%+
- Shijiazhuang Jianxin Biotechnology Co., LTD
2127-03-9(2,2'-Dithiodipyridine )Related Search:
1of4