MONOCLONAL ANTI-HPLK1 (POLO LIKE KINASE 1)
- CAS No.
- Chemical Name:
- MONOCLONAL ANTI-HPLK1 (POLO LIKE KINASE 1)
- Synonyms
- MONOCLONAL ANTI-HPLK1 (POLO LIKE KINASE 1);Monoclonal Anti-hPlk1 (Polo Like Kinase 1) antibody produced in mouse
- CBNumber:
- CB5208140
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MFCD07370940
- MOL File:
- Mol file
MONOCLONAL ANTI-HPLK1 (POLO LIKE KINASE 1) price More Price(1)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | P5998 | Monoclonal Anti-hPlk1 (Polo Like Kinase 1) antibody produced in mouse ~2?mg/mL, clone 35-206, purified immunoglobulin, buffered aqueous solution | 200μL | $633 | 2024-03-01 | Buy |
| Product number | Packaging | Price | Buy |
|---|---|---|---|
| P5998 | 200μL | $633 | Buy |
MONOCLONAL ANTI-HPLK1 (POLO LIKE KINASE 1) Chemical Properties,Uses,Production
Uses
Monoclonal Anti-hPlk1 (Polo Like Kinase 1) antibody produced in mouse has been used in:
- enzyme linked immunosorbent assay (ELISA)
- immunoblotting
- immunoprecipitation
- immunocytochemistry
- immunofluorescence staining
General Description
Monoclonal Anti- hPlk1 (Polo Like Kinase 1) (mouse IgG2b isotype) is derived from the 35-206 hybridoma produced by the fusion of mouse myeloma cells (PAI) and splenocytes from BALB/c mice immunized with human full length Plk1. Polo-like kinases (Plks) are a family of serine/threonine kinases. The Plk family is structurally and functionally related to the polo gene in Drosophila. Plk1 localizes during mitosis in centrosomes, kinetochores and in the central spindle.
Biochem/physiol Actions
Polo Like Kinase 1 (Plk1) has a role in tumor progression. Plk1 is a target of the DNA damage checkpoint on the basis that its activity is inhibited by DNA damage in G2 and mitosis. Moreover, Plk1 was found to bind to the sequence-specific DNA binding domain of p53. This interaction between p53 and Plk1 inhibits the transcriptional activation and the proapoptotic functions of p53.
MONOCLONAL ANTI-HPLK1 (POLO LIKE KINASE 1) Preparation Products And Raw materials
Raw materials
Preparation Products
MONOCLONAL ANTI-HPLK1 (POLO LIKE KINASE 1) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Riedel-de Haen AG | -- | United States | 6773 | 87 | |
| SIGMA-RBI | -- | Switzerland | 6896 | 91 |
| Supplier | Advantage |
|---|---|
| Riedel-de Haen AG | 87 |
| SIGMA-RBI | 91 |