Anti-UV radiation resistance-associated gene
- CAS No.
- Chemical Name:
- Anti-UV radiation resistance-associated gene
- Synonyms
- Anti-UVRAG antibody produced in rabbit;Anti-UV radiation resistance-associated gene
- CBNumber:
- CB52096413
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
Anti-UV radiation resistance-associated gene price More Price(1)
Anti-UV radiation resistance-associated gene Chemical Properties,Uses,Production
Uses
Anti-UVRAG antibody produced in rabbit has been used:
- in western blotting
- in immunofluorescence
General Description
Ultraviolet irradiation resistance-associated gene (UVRAG) is an important autophagic tumor suppressor, encoded by the gene mapped to human chromosome 11q13.5. The encoded protein is characterized with four functional domains, such as proline-rich domain, a lipid-binding C2 domain, a beclin1-binding coiled-coil domain (CCD) and a C-terminal domain involved in centrosome integrity and DNA damage repair.
Biochem/physiol Actions
Ultraviolet irradiation resistance-associated gene (UVRAG) is implicated in the regulation of intracellular membrane trafficking, including autophagy and chromosomal stability. The encoded protein regulates apoptosis by suppressing the BCL2-associated X protein (Bax) activity. Mutation in the gene has been observed in various types of human cancers, including microsatellite unstable colon carcinomas.
Anti-UV radiation resistance-associated gene Preparation Products And Raw materials
Raw materials
Preparation Products
Anti-UV radiation resistance-associated gene Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Riedel-de Haen AG | -- | United States | 6825 | 87 | |
| SIGMA-RBI | -- | Switzerland | 6913 | 91 |
| Supplier | Advantage |
|---|---|
| Riedel-de Haen AG | 87 |
| SIGMA-RBI | 91 |