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Azeliragon

Azeliragon Structure
Azeliragon structure
CAS No.
603148-36-3
Chemical Name:
Azeliragon
Synonyms
TTP488;CRL 40G;TTP 488;TTP-488;CS-2071;AZELIRAGON;PF04494700;PF-04494700;PF 04494700;Neoprene latex
CBNumber:
CB52123238
Molecular Formula:
C32H38ClN3O2
Molecular Weight:
532.12
MDL Number:
MFCD11977600
MOL File:
603148-36-3.mol
MSDS File:
SDS
Last updated:2025-04-18 09:51:10
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Azeliragon Properties

Boiling point 667.7±65.0 °C(Predicted)
Density 1.11±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO:50.33(Max Conc. mg/mL);94.58(Max Conc. mM)
DMF:5.0(Max Conc. mg/mL);9.4(Max Conc. mM)
DMF:PBS (pH 7.2) (1:2):0.33(Max Conc. mg/mL);0.62(Max Conc. mM)
Ethanol:50.5(Max Conc. mg/mL);94.9(Max Conc. mM)
form A crystalline solid
pka 10.16±0.25(Predicted)
color White to light yellow
FDA UNII LPU25F15UQ
UNSPSC Code 12352200
NACRES NA.77

Azeliragon price More Price(12)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 24678 Azeliragon ≥98% 603148-36-3 5mg $62 2024-03-01 Buy
Cayman Chemical 24678 Azeliragon ≥98% 603148-36-3 10mg $109 2024-03-01 Buy
Cayman Chemical 24678 Azeliragon ≥98% 603148-36-3 25mg $166 2024-03-01 Buy
ChemScene CS-5117 Azeliragon 98.79% 603148-36-3 10mg $228 2021-12-16 Buy
ChemScene CS-5117 Azeliragon 98.79% 603148-36-3 5mg $144 2021-12-16 Buy
Product number Packaging Price Buy
24678 5mg $62 Buy
24678 10mg $109 Buy
24678 25mg $166 Buy
CS-5117 10mg $228 Buy
CS-5117 5mg $144 Buy

Azeliragon Chemical Properties,Uses,Production

Uses

Azeliragon (TTP488) is an orally bioavailable inhibitor of the receptor for advanced glycation end products (RAGE) in development as a potential treatment to slow disease progression in patients with mild Alzheimer’s disease (AD)[1]. Azeliragon also can cross the blood-brain barrier (BBB)[2].

Biological Activity

Azeliragon (TTP488, PF-04494700) is an orally bioavailable small molecule inhibitor that inhibits the receptor for advanced glycation end products (RAGE). RAGE is an immunoglobulin-like cell surface receptor that is overexpressed in the brains of Alzheimer's patients.

in vivo

Azeliragon (100 mcg/d; intraperitoneal injection; every day) treatment reduces syngeneic islet graft and islet allograft in NOD and B6 mice (Islets were isolated from young prediabetic NOD/LtJ mice and transplanted into NOD mice with spontaneous diabetes; islets were isolated from WT BALB/c mice and transplanted into B6 mice with diabetes)[3].

Animal Model:Prediabetic NOD/LtJ (6-7 week old) mice, NOD mice with spontaneous diabetes, WT BALB/c mice (8-10 week old) and B6 mice with diabetes [3].
Dosage:100 mcg/d
Administration: Intraperitoneal injection; every day
Result:Prolonged islet auto and allograft survival.

target

References

[1] Burstein AH, et al. Assessment of Azeliragon QTc Liability Through Integrated, Model-Based Concentration QTc Analysis. Clin Pharmacol Drug Dev. 2019 May;8(4):426-435. DOI:10.1002/cpdd.689
[2] Bongarzone S, et al. Targeting the Receptor for Advanced Glycation Endproducts (RAGE): A Medicinal Chemistry Perspective. J Med Chem. 2017 Sep 14;60(17):7213-7232. DOI:10.1021/acs.jmedchem.7b00058
[3] Chen Y, et al. RAGE ligation affects T cell activation and controls T cell differentiation. J Immunol. 2008 Sep 15;181(6):4272-8. DOI:10.4049/jimmunol.181.6.4272

Azeliragon Preparation Products And Raw materials

Raw materials

Preparation Products

Azeliragon Suppliers

Global( 92)Suppliers
TargetValue
RAGE
()
Supplier Tel Email Country ProdList Advantage
Nanjing Finetech Chemical Co., Ltd. 		025-85710122 17714198479 sales@fine-chemtech.com CHINA 885 55
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29858 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19552 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32159 58
Hubei Ipure Biology Co., Ltd 		+8613367258412 ada@ipurechemical.com China 10244 58
HONG KONG IPURE BIOLOGY CO.,LIMITED 		86 18062405514 18062405514 ada@ipurechemical.com CHINA 3461 58
Alfa Chemistry 		Info@alfa-chemistry.com United States 24072 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		13417589054 trendseenbio@gmail.com China 11681 58
Supplier Advantage
Nanjing Finetech Chemical Co., Ltd. 		55
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
BOC Sciences 		58
TargetMol Chemicals Inc. 		58
Hubei Ipure Biology Co., Ltd 		58
HONG KONG IPURE BIOLOGY CO.,LIMITED 		58
Alfa Chemistry 		58
InvivoChem 		58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		58

View Lastest Price from Azeliragon manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Azeliragon pictures 2024-11-19 Azeliragon
603148-36-3
 US $33.00-80.00 / mg 98.32% 10g TargetMol Chemicals Inc.
Azeliragon pictures 2019-09-06 Azeliragon
603148-36-3
 US $1.00 / KG 1KG 95%~99% per week 100kg Career Henan Chemical Co
  • Azeliragon pictures
  • Azeliragon
    603148-36-3
  • US $33.00-80.00 / mg
  • 98.32%
  • TargetMol Chemicals Inc.
  • Azeliragon pictures
  • Azeliragon
    603148-36-3
  • US $1.00 / KG
  • 95%~99%
  • Career Henan Chemical Co

Azeliragon Spectrum

Azeliragon(603148-36-3)1HNMR
1-PropanaMine, 3-[4-[2-butyl-1-[4-(4-chlorophenoxy)phenyl]-1H-iMidazol-4-yl]phenoxy]-N,N-diethyl- CRL 40G 3-(4-(2-butyl-1-(4-(4-chlorophenoxy)phenyl)-1H-imidazol-4-yl)phenoxy)-N,N-diethylpropan-1-amine AZELIRAGON 3--4--2-Butyl-1--4--4-chlorphenoxy-phenyl--1H-imidazol-4-yl-phenoxy--N-N-diethylpropan-1-amin N-[3-[4-[2-Butyl-1-[4-(4-chlorophenoxy)phenyl]-1H-imidazol-4-yl]phenoxy]propyl]-N,N-diethylamine Azeliragon (TTP488) Azeliragon(PF-04494700,TTP488) PF 04494700 PF04494700 PF-04494700 PF04494700;TTP-488;PF 04494700;TTP 488;PF-04494700;TTP488 TTP 488 TTP488 TTP-488 CS-2071 PF-04494700,TTP488 3-(4-{2-Butyl-1-[4-(4-chloro-phenoxy)-phenyl]-1H-imidazol-4-yl}-phenoxy)-propyl]-diethyl-amine Azeliragon/603148-36-3/99% purity with low price in stock Abeta,PF 04494700,Amyloid-β,TTP-488,Azeliragon,inhibit,PF04494700,PF-04494700,β-amyloid peptide,Inhibitor,TTP 488 3-[4-[2-Butyl-1-[4-(4-chlorophenoxy)phenyl]-1H-imidazol-4-yl]phenoxy]-N,N-diethyl-1-propanamine Neoprene latex Azeliragon, 10 mM in DMSO 603148-36-3 C32H38ClN3O2 Inhibitors