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REVERSE T3

REVERSE T3 structure

CAS No.: 5817-39-0

Chemical Name:: REVERSE T3

Synonyms: T3;TRIIODOTHYRONINE;rT3;LIOTHYRONIN;Reverse triiodothyronine;(2S)-2-aMino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3-iodophenyl]propanoic acid;L-T3-13C6;REVERSE T3;REVERSE T3;3,3',5'-T3

CBNumber:: CB5221268

Molecular Formula:: C15H12I3NO4

Molecular Weight:: 650.97

MDL Number:: MFCD00036864

MOL File:: 5817-39-0.mol

MSDS File:: SDS

Last updated:2024-11-19 23:02:33

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REVERSE T3 Properties

Melting point	234-238 °C(lit.)
Boiling point	534.6±50.0 °C(Predicted)
Density	2.387±0.06 g/cm3(Predicted)
Flash point	9℃
storage temp.	Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility	DMSO (Slightly), Methanol (Slightly)
form	powder
pka	2.17±0.20(Predicted)
color	Pale Beige to Brown
Stability	Light Sensitive
InChI	InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)/t12-/m0/s1
InChIKey	HZCBWYNLGPIQRK-LBPRGKRZSA-N
SMILES	C(O)(=O)[C@H](CC1=CC=C(OC2=CC(I)=C(O)C(I)=C2)C(I)=C1)N
NCI Dictionary of Cancer Terms	T-3; triiodothyronine
FDA UNII	8NZ4Y08T96

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302+H312+H332

Precautionary statements

P261-P264-P280-P301+P312-P302+P352+P312-P304+P340+P312

Hazard Codes

Xn,T,F

Risk Statements

36/37/38-20/21/22-39/23/24/25-23/24/25-11

Safety Statements

36-45-36/37-16

RIDADR

UN1230 - class 3 - PG 2 - Methanol, solution

WGK Germany

RTECS

AY6750000

HS Code

29379000

NFPA 704

	0
3		0

REVERSE T3 price More Price(32)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	T-075	3,3′,5′-Triiodo-L-thyronine (Reverse T3) solution 100?μg/mL in methanol with 0.1N NH3, ampule of 1?mL, certified reference material, Cerilliant?	5817-39-0	1mL	$135	2024-03-01	Buy
Cayman Chemical	17598	3,3',5'-Triiodo-L-thyronine ≥95%	5817-39-0	5mg	$85	2024-03-01	Buy
Cayman Chemical	17598	3,3',5'-Triiodo-L-thyronine ≥95%	5817-39-0	10mg	$162	2024-03-01	Buy
Cayman Chemical	17598	3,3',5'-Triiodo-L-thyronine ≥95%	5817-39-0	25mg	$380	2024-03-01	Buy
Cayman Chemical	17598	3,3',5'-Triiodo-L-thyronine ≥95%	5817-39-0	50mg	$674	2024-03-01	Buy

Product number	Packaging	Price	Buy
T-075	1mL	$135	Buy
17598	5mg	$85	Buy
17598	10mg	$162	Buy
17598	25mg	$380	Buy
17598	50mg	$674	Buy

REVERSE T3 Chemical Properties,Uses,Production

Description

Either a derivative or precursor of thyroxine. Triiodothyronine increases themetabolic rate and oxygen consumption of animal tissues. Used in biochemical research, medicine (metabolic insufficiency).

Chemical Properties

Beige Powder

Uses

Of interest for the early detection and treatment of congenital or drug-induced hypothyroidism in the developing human fetus.

Uses

One of the hormones produced by the thyroid gland that is involved in the maintenance of metabolic homeostasis. Also produced in peripheral tissues as the active metabolite of Thyroxine.

Definition

ChEBI: 3,3',5'-triiodo-L-thyronine is a 3,3',5'-triiodothyronine. It is a tautomer of a 3,3',5'-triiodo-L-thyronine zwitterion.

Biological Activity

3,3',5'-triiodo-l-thyronine (reverse t3 or rt3) and 3,5,3'-triiodo-l-thyronine (t3) are the metabolism of thyroxine (t4) [1]. 3,3',5'-triiodo-l-thyronine is thyroid hormone receptors trα and trβ antagonist [1].thyroid hormones play important roles in the development of the mammalian brain by acting on migration and differentiation of neural cells, synaptogenesis, and myelination. the actions of thyroid hormones are mediated by nuclear thyroid hormone receptors (trs) and regulation of gene expression. trs have been also involved in adult brain function. in adult mice, trα1 deletion and a dominant negative mutant receptor expression induce consistent behavioral changes leading to severe anxiety and morphological changes in the hippocampus [2].the rt3 was about 1,000-fold less active at the thyroid hormone receptors trα and trβ compared with 3,3',5-triiodo-l-thyronine and commonly described as inactive [1].it has been reported that rt3 activates a native form of trα, trδα1, which lacks a nuclear localization signal and functions in the cytoplasm. through this action, rt3 initiates actin polymerization, particularly in astrocytes and neurons [3].

References

[1] nicod p, burger a, staeheli v, et al. a radioimmunoassay for 3, 3′, 5′-triiodo-l-thyronine in unextracted serum: method and clinical results[j]. the journal of clinical endocrinology & metabolism, 1976, 42(5): 823-829.
[2] bernal j. thyroid hormone receptors in brain development and function[j]. nature clinical practice endocrinology & metabolism, 2007, 3(3): 249-259.
[3] senese r, cioffi f, de lange p, et al. thyroid: biological actions of ‘nonclassical’thyroid hormones[j]. journal of endocrinology, 2014, 221(2): r1-r12.

REVERSE T3 synthesis

Synthesis of REVERSE T3 from N-Acetyl-3-iodo-L-tyrosine, Amide

REVERSE T3 Preparation Products And Raw materials

Raw materials

Preparation Products

REVERSE T3 Suppliers

Global( 225)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Wuhan senwayer century chemical Co.,Ltd	+undefined-27-86652399 +undefined13627115097	market02@senwayer.com	China	902	58
Shenzhen Monkono Technology Co.,Ltd	+86-17063441314	sansbiotech@outlook.com	China	677	58
Wuhan Quanjinci New Material Co.,Ltd.	+86-15271838296; +8615271838296	kyra@quanjinci.com	China	1512	58
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	18777	58
Hangzhou FandaChem Co.,Ltd.	+8615858145714	FandaChem@Gmail.com	China	9210	55
Cangzhou Wanyou New Material Technology Co.,Ltd	18631714998	sales@czwytech.com	CHINA	904	58
Xi'an Kono chem co., Ltd.,	029-86107037 13289246953	info@konochemical.com	China	2993	58
Shochem(Shanghai) Co.,Ltd	86-21-50800795	info@shochem.com	CHINA	288	58
Standardpharm Co. Ltd.	86-714-3992388	overseasales1@yongstandards.com	United States	14332	58
Shanghai Longyu Biotechnology Co., Ltd.	+8619521488211	info@longyupharma.com	China	2541	58

Supplier	Advantage
Wuhan senwayer century chemical Co.,Ltd	58
Shenzhen Monkono Technology Co.,Ltd	58
Wuhan Quanjinci New Material Co.,Ltd.	58
Shanghai Daken Advanced Materials Co.,Ltd	58
Hangzhou FandaChem Co.,Ltd.	55
Cangzhou Wanyou New Material Technology Co.,Ltd	58
Xi'an Kono chem co., Ltd.,	58
Shochem(Shanghai) Co.,Ltd	58
Standardpharm Co. Ltd.	58
Shanghai Longyu Biotechnology Co., Ltd.	58

View Lastest Price from REVERSE T3 manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-11-22	T3 (Liothyronine sodium) 5817-39-0	US $45.00-35.00 / kg	1kg	99.9%	2000kg	hebei hongtan Biotechnology Co., Ltd
2024-11-19	REVERSE T3 5817-39-0	US $42.00-83.00 / mg		97.66%	10g	TargetMol Chemicals Inc.
2024-09-25	Triiodothyronine/REVERSE T3 5817-39-0	US $8470.00 / KG	1KG	99% min	20 TONS	Wuhan Senwayer Century Chemical Co.,Ltd

T3 (Liothyronine sodium)
5817-39-0
US $45.00-35.00 / kg
99.9%
hebei hongtan Biotechnology Co., Ltd

REVERSE T3
5817-39-0
US $42.00-83.00 / mg
97.66%
TargetMol Chemicals Inc.

Triiodothyronine/REVERSE T3
5817-39-0
US $8470.00 / KG
99% min
Wuhan Senwayer Century Chemical Co.,Ltd

REVERSE T3 Spectrum

REVERSE T3(5817-39-0)¹HNMR

5817-39-0(REVERSE T3)Related Search:

Sodium levothyroxine 3,3',5-Triiodo-L-thyronine Benzenepropanoic acid, 5-[4-(cyclopentyloxy)-2-hydroxybenzoyl]-2-[(2,3-dihydro-3-oxo-1,2-benzisoxazol-6-yl)Methoxy]- T0901317 T5601640

Thyroxine-4-hydroxy-3,5-diiodophenyl Ether DISCONTINUED 4-(4-Hydroxyphenoxy)-3,5-diiodo-benzaldehyde 3,5-DIIODO-4'-(4-HYDROXYPHENOXY)BENZOIC ACID Levothyroxine EP Impurity B Levothyroxine Impurity 16

N-ForMyl Thyroxine 3,5,3',5'-Tetraiodo Thyroaldehyde Levothyroxine O-Methyl Amine Impurity O-(4-hydroxy-3-iodophenyl)-3-iodo-L-tyrosine 3,5-Diiodo-4-(p-Methoxyphenoxy)-benzaldehyde

3,5-Diiodo-L-thyronine 3,3',5-TRIIODOTHYROPROPIONIC ACID 3-IODO-L-TYROSINE

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Reverse T3 (3,3',5'-Triiodo-L-Thyronine) L-Tyrosine,O-(4-hydroxy-3,5-diiodophenyl)-3-iodo- REVERSE T3 L-3,3',5'-TRIIODOTHYRONINE 3,3′,5′-Triiodo-L-thyronine (Reverse T3) solution Levothyroxine EP Impurity K 3,3',5'-TRIIODO-L-THYRONINE, THYROID Reverse L-triiodothyronine (S)-2-Amino-3-(4-(4-hydroxy-3,5-diiodophenoxy)-3-iodophenyl)propanoic acid Reverse T₃ 3,3',5'-triiodo-L-thyronine free acid Isoliothyronine 3,3’,5-Triiodo-L-thyronine-13C6 3,3’,5-Triiodothyronine-13C6 Liothyronine-13C6 L-T3-13C6 O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine-13C6 T3 (Hormone)-13C6 Tresitope-13C6 Triiodothyronine-13C6 (3,5,3')-TRIIODO-L-THYRONINE (S)-3-[4-(4-Hydroxy-3,5-diiodophenoxy)-3-iodophenyl]-2-aminopropanoic acid triiodothyronine,reverse 3,3′,5′-Triiodo-L-thyronine 3,3′,5′-Triiodo-L-thyronine 3,3′,5′-Triiodo-L-thyronine thyroid horMone analog O-(4-hydroxy-3,5-diiodophenyl)-3-iodo-L-Tyrosine REVERSE T3 Levothyroxine Impurity 10（Levothyroxine EP Impurity K） Levothyroxine Impurity K Levothyroxine EP Imp K 3, 3', 5'- Triiodothyronine (Solution) Triiodothyronine (L-Liothyronine Reverse Triiodothyronine hydrochloride (Reverse T3) (S)-2-Amino-3-(4-(4-hydroxy-3,5-diiodophenoxy)-3-iodophenyL REVERSE T3 USP/EP/BP 3,3',5'-L-Triiodothyronine 3,3',5'-T3 Alanine,3-[4-(4-hydroxy-3,5-diiodophenoxy)-3-iodophenyl]-, L- (8CI) Levothyroxine EP Impurity KQ: What is Levothyroxine EP Impurity K Q: What is the CAS Number of Levothyroxine EP Impurity K Q: What is the storage condition of Levothyroxine EP Impurity K Q: What are the applications of Levothyroxine EP Impurity K 6-Tetramethyl-4-piperidinone (2S)-2-aMino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3-iodophenyl]propanoic acid T3 LIOTHYRONIN rT3 Reverse triiodothyronine TRIIODOTHYRONINE Triiodothyronine。REVERSE T3 Zebrafish triiodothyronine (T3) ELISA Kit Levothyroxine EP Impurity K (3,3',5'-Triiodo-L-thyronine) Levothyroxine Sodium EP Impurity K Liothyronine Triiodothyronin 3, 3', 5'- Triiodothyronine 3,3',5'-Triiodo-L-thyronine 3,3'',5''-Triiodo-L-thyronine 3,3',5'-triiodo-L-thyronine(T3) Levothyroxine t3 3',5',3-Triiodothyronine 3.3‘.5‘- Triiodothyronine (Rev T3) in Methanol