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Tylophorinine

Tylophorinine Structure
Tylophorinine structure
CAS No.
6799-27-5
Chemical Name:
Tylophorinine
Synonyms
Tylophorinine;Dibenzo[f,h]pyrrolo[1,2-b]isoquinolin-14-ol, 9,11,12,13,13a,14-hexahydro-3,6,7-trimethoxy-, (13aR,14S)-rel-
CBNumber:
CB52219049
Molecular Formula:
C23H25NO4
Molecular Weight:
379.45
MDL Number:
MOL File:
6799-27-5.mol
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Tylophorinine Properties

Melting point 248-9°C
Boiling point 588.5±50.0 °C(Predicted)
Density 1.31±0.1 g/cm3(Predicted)
pka 13.48±0.20(Predicted)

Tylophorinine Chemical Properties,Uses,Production

Description

An alkaloid of Tylophora asthmatica, the base crystallizes as the hemihydrate, m.p. 232-3°C (dec.) and has[α]27D - 14.2° (c 1.76, CHCI3). The ultraviolet spectrum in MeOH has absorption maxima at 258, 287 and 340 Mu. The salts crystallize well, e.g. the hydrochloride, m.p. 257°C (dec.); nitrate, m.p. 240- 2°C; methiodide, m.p. 243-5°C (dec.) and the O-acetate, m.p. 222-3°C.

References

Hooper., Pharm. J., 21,6 (1891)
Chopra et al., Arch. Pharm., 275,236 (1937)
Govindachari, Pai, Nagarajan.,J. Chem. Soc., 2801 (1954)
Govindachari et al., Tetrahedron, 14,288 (1961)

Tylophorinine Preparation Products And Raw materials

Raw materials

Preparation Products

Tylophorinine Dibenzo[f,h]pyrrolo[1,2-b]isoquinolin-14-ol, 9,11,12,13,13a,14-hexahydro-3,6,7-trimethoxy-, (13aR,14S)-rel- 6799-27-5