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ChemicalBook >> CAS DataBase List >>BENZAMIDE, 3,5-DICHLORO-N-[[4-FLUORO-1-[(TETRAHYDRO-2,2-DIMETHYL-2H-PYRAN-4-YL)METHYL]-4-PIPERIDINYL]METHYL]-, (+)-

BENZAMIDE, 3,5-DICHLORO-N-[[4-FLUORO-1-[(TETRAHYDRO-2,2-DIMETHYL-2H-PYRAN-4-YL)METHYL]-4-PIPERIDINYL]METHYL]-, (+)-

BENZAMIDE, 3,5-DICHLORO-N-[[4-FLUORO-1-[(TETRAHYDRO-2,2-DIMETHYL-2H-PYRAN-4-YL)METHYL]-4-PIPERIDINYL]METHYL]-, (+)- Structure
BENZAMIDE, 3,5-DICHLORO-N-[[4-FLUORO-1-[(TETRAHYDRO-2,2-DIMETHYL-2H-PYRAN-4-YL)METHYL]-4-PIPERIDINYL]METHYL]-, (+)- structure
CAS No.
918430-49-6
Chemical Name:
BENZAMIDE, 3,5-DICHLORO-N-[[4-FLUORO-1-[(TETRAHYDRO-2,2-DIMETHYL-2H-PYRAN-4-YL)METHYL]-4-PIPERIDINYL]METHYL]-, (+)-
Synonyms
(Rac)-TTA-P2;3,5-Dichloro-N-[[4-fluoro-1-[(tetrahydro-2,2-dimethyl-2H-pyran-4-yl)methyl]-4-piperidinyl]methyl]ben;3,5-dichloro-N-((1-((2,2-diMethyltetrahydro-2H-pyran-4-yl)Methyl)-4-fluoropiperidin-4-yl)Methyl)benzaMide;3,5-Dichloro-N-[[4-fluoro-1-[(tetrahydro-2,2-dimethyl-2H-pyran-4-yl)methyl]-4-piperidinyl]methyl]Benzamide;BENZAMIDE, 3,5-DICHLORO-N-[[4-FLUORO-1-[(TETRAHYDRO-2,2-DIMETHYL-2H-PYRAN-4-YL)METHYL]-4-PIPERIDINYL]METHYL]-;BENZAMIDE, 3,5-DICHLORO-N-[[4-FLUORO-1-[(TETRAHYDRO-2,2-DIMETHYL-2H-PYRAN-4-YL)METHYL]-4-PIPERIDINYL]METHYL]-, (+)-
CBNumber:
CB52468540
Molecular Formula:
C21H29Cl2FN2O2
Molecular Weight:
431.37
MDL Number:
MFCD11977740
MOL File:
918430-49-6.mol
MSDS File:
SDS
Last updated:2023-04-23 13:52:06
Request For Quotation

BENZAMIDE, 3,5-DICHLORO-N-[[4-FLUORO-1-[(TETRAHYDRO-2,2-DIMETHYL-2H-PYRAN-4-YL)METHYL]-4-PIPERIDINYL]METHYL]-, (+)- Properties

Boiling point 510.1±50.0 °C(Predicted)
Density 1.25±0.1 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
solubility Soluble in DMSO (10 mg/ml)
form solid
pka 13.65±0.46(Predicted)
color Tan
Stability Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

BENZAMIDE, 3,5-DICHLORO-N-[[4-FLUORO-1-[(TETRAHYDRO-2,2-DIMETHYL-2H-PYRAN-4-YL)METHYL]-4-PIPERIDINYL]METHYL]-, (+)- price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
AK Scientific 2018CW 3,5-Dichloro-N-[[1-[(2,2-dimethyloxan-4-yl)methyl]-4-fluoropiperidin-4-yl]methyl]benzamide 918430-49-6 100mg $111 2021-12-16 Buy
AK Scientific 2018CW 3,5-Dichloro-N-[[1-[(2,2-dimethyloxan-4-yl)methyl]-4-fluoropiperidin-4-yl]methyl]benzamide 918430-49-6 250mg $142 2021-12-16 Buy
AK Scientific 2018CW 3,5-Dichloro-N-[[1-[(2,2-dimethyloxan-4-yl)methyl]-4-fluoropiperidin-4-yl]methyl]benzamide 918430-49-6 1g $254 2021-12-16 Buy
Chemenu CM255767 3,5-Dichloro-N-((1-((2,2-dimethyltetrahydro-2H-pyran-4-yl)methyl)-4-fluoropiperidin-4-yl)methyl)benzamide 95+% 918430-49-6 1g $514 2021-12-16 Buy
Crysdot CD11015926 3,5-Dichloro-N-((1-((2,2-dimethyltetrahydro-2H-pyran-4-yl)methyl)-4-fluoropiperidin-4-yl)methyl)benzamide 97% 918430-49-6 1g $545 2021-12-16 Buy
Product number Packaging Price Buy
2018CW 100mg $111 Buy
2018CW 250mg $142 Buy
2018CW 1g $254 Buy
CM255767 1g $514 Buy
CD11015926 1g $545 Buy

BENZAMIDE, 3,5-DICHLORO-N-[[4-FLUORO-1-[(TETRAHYDRO-2,2-DIMETHYL-2H-PYRAN-4-YL)METHYL]-4-PIPERIDINYL]METHYL]-, (+)- Chemical Properties,Uses,Production

Description

TTA-P2 (918430-49-6) is a potent (IC50 = 100 nM), specific, and reversible antagonist of T-type calcium channels with no activity at high voltage calcium channels.1,2 Highly potent in two animal models of pain in vivo.3

References

Shipe et al. (2008), Design, synthesis, and evaluation of a novel 4-aminomethyl-4-fluoropiperidine as a T-type Ca2+ channel antagonist; J. Med. Chem., 51 3692 Dreyfus et al. (2010), Selective T-type calcium channel block in thalamic neurons reveals channel redundancy and physiological impact of I(T)window; J. Neurosci., 30 99 Choe et al. (2011), TTA-P2 is a potent and selective blocker of T-type calcium channels in rat sensory neurons and a novel antinociceptive agent; Mol. Pharmacol., 80 900

BENZAMIDE, 3,5-DICHLORO-N-[[4-FLUORO-1-[(TETRAHYDRO-2,2-DIMETHYL-2H-PYRAN-4-YL)METHYL]-4-PIPERIDINYL]METHYL]-, (+)- Preparation Products And Raw materials

Raw materials

Preparation Products

BENZAMIDE, 3,5-DICHLORO-N-[[4-FLUORO-1-[(TETRAHYDRO-2,2-DIMETHYL-2H-PYRAN-4-YL)METHYL]-4-PIPERIDINYL]METHYL]-, (+)- Suppliers

Global( 18)Suppliers
Supplier Tel Email Country ProdList Advantage
Career Henan Chemica Co 		+86-0371-86658258 +8613203830695 laboratory@coreychem.com China 30233 58
CD Chemical Group Limited 		+8615986615575 info@codchem.com China 20342 58
Allfluoro pharmaceutical co. ltd. 		+86-400-0216110 +86-15958047586 sales@allfluoro.com China 11385 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131957 58
Acesys Pharmatech 18860950986 tangmanman@zenjipharma.com China 1733 55
Shanghai Balmxy Pharmaceutical Co., Ltd 021-24206007 13764915196 sales@balmxy.com China 6787 55
Nanjing Shizhou Biology Technology Co.,Ltd 025-85560043 13675144456 sean.lv@synzest.com China 11438 58
Shanghai Haohong Pharmaceutical Co., Ltd. 400-8210725 4008210725 malulu@leyan.com China 39995 58
Shanghai Universal Biotech Co.,Ltd 13774214275 zhouzz@univ-bio.com China 24998 58
Bide Pharmatech Ltd. 400-1647117 13681763483 product02@bidepharm.com China 62075 58
Supplier Advantage
Career Henan Chemica Co 		58
CD Chemical Group Limited 		58
Allfluoro pharmaceutical co. ltd. 		58
Amadis Chemical Company Limited 		58
Acesys Pharmatech 55
Shanghai Balmxy Pharmaceutical Co., Ltd 55
Nanjing Shizhou Biology Technology Co.,Ltd 58
Shanghai Haohong Pharmaceutical Co., Ltd. 58
Shanghai Universal Biotech Co.,Ltd 58
Bide Pharmatech Ltd. 58

918430-49-6(BENZAMIDE, 3,5-DICHLORO-N-[[4-FLUORO-1-[(TETRAHYDRO-2,2-DIMETHYL-2H-PYRAN-4-YL)METHYL]-4-PIPERIDINYL]METHYL]-, (+)-)Related Search:

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BENZAMIDE, 3,5-DICHLORO-N-[[4-FLUORO-1-[(TETRAHYDRO-2,2-DIMETHYL-2H-PYRAN-4-YL)METHYL]-4-PIPERIDINYL]METHYL]- BENZAMIDE, 3,5-DICHLORO-N-[[4-FLUORO-1-[(TETRAHYDRO-2,2-DIMETHYL-2H-PYRAN-4-YL)METHYL]-4-PIPERIDINYL]METHYL]-, (+)- 3,5-Dichloro-N-[[4-fluoro-1-[(tetrahydro-2,2-dimethyl-2H-pyran-4-yl)methyl]-4-piperidinyl]methyl]Benzamide 3,5-dichloro-N-((1-((2,2-diMethyltetrahydro-2H-pyran-4-yl)Methyl)-4-fluoropiperidin-4-yl)Methyl)benzaMide 3,5-Dichloro-N-[[4-fluoro-1-[(tetrahydro-2,2-dimethyl-2H-pyran-4-yl)methyl]-4-piperidinyl]methyl]ben (Rac)-TTA-P2 918430-49-6 C21H29Cl2FN2O2