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ChemicalBook >> CAS DataBase List >>N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide Hcl

N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide Hcl

N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide Hcl Structure
N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide Hcl structure
CAS No.
902135-91-5
Chemical Name:
N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide Hcl
Synonyms
CS-266;AT 7519;AT7519 HCl;AT-7519(HCI);AT-7519 diHCl;AT7519; AT-7519;AT7519 HCl, >=99%;AT 7519 HCl salt;Light yellow solid;AT7519 (Hydrochloride)
CBNumber:
CB52473801
Molecular Formula:
C16H18Cl3N5O2
Molecular Weight:
418.7
MDL Number:
MFCD14636428
MOL File:
902135-91-5.mol
Last updated:2024-11-19 20:33:22
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N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide Hcl Properties

storage temp. Store at -20°C
solubility ≥29.93 mg/mL in H2O; ≥43.3 mg/mL in DMSO with ultrasonic; ≥8.82 mg/mL in EtOH with ultrasonic
form crystalline solid
color White to off-white
FDA UNII X1BF92PW9T

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P264-P270-P271-P280-P301+P312-P330-P302+P352-P321-P304+P340-P305+P351+P338-P332+P313-P362+P364-P337+P313-P403+P233-P405-P501
NFPA 704
0
2 0

N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide Hcl price More Price(33)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 16231 AT7519 (hydrochloride) ≥98% 902135-91-5 1mg $32 2024-03-01 Buy
Cayman Chemical 16231 AT7519 (hydrochloride) ≥98% 902135-91-5 5mg $104 2024-03-01 Buy
Cayman Chemical 16231 AT7519 (hydrochloride) ≥98% 902135-91-5 10mg $174 2024-03-01 Buy
Cayman Chemical 16231 AT7519 (hydrochloride) ≥98% 902135-91-5 25mg $315 2024-03-01 Buy
TRC D432100 4-(2,6-Dichlorobenzoylamino)-1H-pyrazole-3-carboxylicAcidPiperidin-4-ylamideMonohydrochloride 902135-91-5 5mg $165 2021-12-16 Buy
Product number Packaging Price Buy
16231 1mg $32 Buy
16231 5mg $104 Buy
16231 10mg $174 Buy
16231 25mg $315 Buy
D432100 5mg $165 Buy

N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide Hcl Chemical Properties,Uses,Production

Description

AT7519 is an ATP-competitive inhibitor of cyclin-dependent kinases (Cdks) with IC50 values of 210, 47, 100, 13, 170, and <10 nM for Cdk1, 2, 4, 5, 6, and 9, respectively. It is less potent against Cdk3 and Cdk7 and inactive against non-Cdk kinases save for GSK3β (IC50 = 89 nM). AT7519 demonstrates antiproliferative activity against a wide variety of human tumor cell lines (IC50s = 40-940 nM in vitro), inhibiting cell cycle progression and inducing apoptosis, and prevents tumor growth in human tumor xenograft models. AT7519 induces activation of GSK3β by down-regulating GSK3β phosphorylation, which contributes to AT7519-induced apoptosis.

Uses

4-(2,6-DichlorobenzoylaMino)-1H-pyrazole-3-carboxylic Acid Piperidin-4-ylaMide Monohydrochloride is used in the structure based design of a cyclin-dependant kinase CDK2 inhibitor.

Uses

4-(2,6-Dichlorobenzoylamino)-1H-pyrazole-3-carboxylic Acid Piperidin-4-ylamide is used in the structure based design of a cyclin-dependant kinase CDK2 inhibitor.

N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide Hcl Preparation Products And Raw materials

Raw materials

Preparation Products

N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide Hcl Suppliers

Global( 132)Suppliers
Supplier Tel Email Country ProdList Advantage
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29791 60
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32957 60
Biochempartner 		0086-13720134139 candy@biochempartner.com CHINA 965 58
Changzhou PBpharmaceutical R&D Co.,Ltd 		0519-83990708 info@pbpharm.com CHINA 498 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19553 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49374 58
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29811 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32165 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10473 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
Supplier Advantage
Capot Chemical Co.,Ltd. 		60
ATK CHEMICAL COMPANY LIMITED 		60
Biochempartner 		58
Changzhou PBpharmaceutical R&D Co.,Ltd 		58
BOC Sciences 		58
CONIER CHEM AND PHARMA LIMITED 		58
career henan chemical co 		58
TargetMol Chemicals Inc. 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
InvivoChem 		58

View Lastest Price from N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide Hcl manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
AT7519 Hydrochloride pictures 2024-11-19 AT7519 Hydrochloride
902135-91-5
 US $52.00-113.00 / mg 99.9% 10g TargetMol Chemicals Inc.
N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide Hcl pictures 2022-10-14 N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide Hcl
902135-91-5
 US $0.00-0.00 / KG 1KG 98% 1Ton Henan Aochuang Chemical Co.,Ltd.
N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide Hcl pictures 2019-12-23 N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide Hcl
902135-91-5
 US $1.00 / ASSAYS 100ASSAYS 98%min G/KG/T Career Henan Chemical Co

N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide Hcl Spectrum

N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide Hcl(902135-91-5)1HNMR

902135-91-5(N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide Hcl)Related Search:

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N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide Hcl AT 7519 N-(4-Piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide hydrochloride AT7519 (Hydrochloride) Light yellow solid 4-(2,6-Dichlorobenzoylamino)-1H-pyrazole-3-carboxylic Acid Piperidin-4-ylamide Monohydrochloride AT 7519 N-(4-Piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide hydrochloride AT 7519 HCl salt AT7519 HCl AT-7519(HCI) AT7519 HCl, >=99% AT 7519 hydrochloride salt 4-(2,6-Dichlorobenzamido)-N-(piperidin-4-yl)-1H-pyrazole-3-carboxamide hydrochloride AT7519;AT-7519;AT 7519 HYDROCHLORIDE;AT-7519 HYDROCHLORIDE 4-(2,6-Dichlorobenzamido)-N-(piperidin-4-yl)-1H-pyrazole-3-carboxamide HCl CS-266 AT7519; AT-7519 AT-7519 diHCl 902135-91-5 C16H17Cl2N5O2HCl C16H18Cl3N5O2 C16H17Cl2N5O2ClH Inhibitors