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Thiamet G Discontinued

CAS No.
1009816-48-1
Chemical Name:
Thiamet G Discontinued
Synonyms
CS-1700;Thiamet G;Thiamet H;Thiamet G0nDiscontinued;Thiamet G Discontinued ;Thiamet G_x000b_Discontinued;1,2-Dideoxy-2'-ethylamino-a-D-glucopyranoso-[2,1-d]-2'-thiazoline;2-(ethylaMino)-5-(hydroxyMethyl)-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d]thiazole-6,7-dio;2-(ethylamino)-3aR,6S,7R,7aR-tetrahydro-5R-(hydroxymethyl)-5H-pyrano[3,2-d]thiazole-6,7-diol;(3aR,5R,6S,7R,7aR)-2-(Ethylamino)-5-(hydroxymethyl)-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d]thiazole-6,7-diol
CBNumber:
CB52485666
Molecular Formula:
C9H16N2O4S
Molecular Weight:
248.3
MDL Number:
MFCD15144964
MOL File:
1009816-48-1.mol
MSDS File:
SDS
Last updated:2024-11-19 23:02:33

Thiamet G Discontinued Properties

Boiling point 483.2±55.0 °C(Predicted)
Density 1.74±0.1 g/cm3(Predicted)
storage temp. -20°C
solubility H2O: ≥5mg/mL at warmed to 60°C
form powder
pka 13.17±0.70(Predicted)
color white to beige
optical activity [α]/D -21 to -26°, c = 0.3 in methanol
Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
InChIKey PPAIMZHKIXDJRN-UKPHHSARSA-N

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H317
Precautionary statements  P261-P280
WGK Germany  3

Thiamet G Discontinued price More Price(26)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML0244 Thiamet G ≥98% (HPLC) 1009816-48-1 5mg $127 2024-03-01 Buy
Sigma-Aldrich SML0244 Thiamet G ≥98% (HPLC) 1009816-48-1 25mg $505 2024-03-01 Buy
Cayman Chemical 13237 Thiamet G ≥97% 1009816-48-1 1mg $40 2024-03-01 Buy
Cayman Chemical 13237 Thiamet G ≥97% 1009816-48-1 5mg $89 2024-03-01 Buy
Cayman Chemical 13237 Thiamet G ≥97% 1009816-48-1 10mg $133 2024-03-01 Buy
Product number Packaging Price Buy
SML0244 5mg $127 Buy
SML0244 25mg $505 Buy
13237 1mg $40 Buy
13237 5mg $89 Buy
13237 10mg $133 Buy

Thiamet G Discontinued Chemical Properties,Uses,Production

Description

Thiamet G (1009816-48-1) is a potent, selective inhibitor of O-GlcNAcase (Ki?= 21 nM for human O-GlcNAcase). Increases levels of O-GlcNAc-modified proteins in cellular assays and?in vivo. Suppresses phosphorylation of tau protein in rat cortex and hippocampus.1?Stabilizes tau against aggregation and slows neurodegeneration.2?Thiamet G prevents cognitive decline and amyloid plaque formation in bigenic tau/APP mutant mice.3?Elevates soluble tau species and reduces tauopathy in mouse models.4?Active?in vivo?and blood brain barrier permeable.

Uses

A potent O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo. The authors anticipate that Thiamet-G will find wide use in probing the functional role of O-GlcNAc in vertebrate brain, and it may also offer a route to blocking pathological hyperphosphorylation of tau in AD. Anti-Alzheimer''s agent.

Uses

As a potent O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo, The authors anticipate that Thiamet-G will find wide use in probing the functional role of O-GlcNAc in vertebrate brain, and it may also offer a route to blocking pathological

Biochem/physiol Actions

Thiamet G is a potent inhibitor of the enzyme O-GlcNAcase (Ki = 21 nM). The compound is orally bioavailable and crosses the blood brain barrier. Thiamet G leads to an increase in O-GlcNAc-modified proteins in cell-based and in vivo assay systems, and reduces levels of phosphorylated Tau protein in rat cortex and hippocampus.

storage

Store at -20°C

References

1) Yuzwa?et al. (2008),?A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo; Nat. Chem. Biol.,?4?483 2) Yuzwa?et al. (2012),?Increasing O-GlcNAc slows neurodegeneration and stabilizes tau against aggregation; Nat. Chem. Biol.?8?393 3) Yuzwa?et al. (2014),?Pharmacological inhibition of O-GlcNAcase (OGA) prevents cognitive decline and amyloid plaque formation in bigenic tau/APP mutant mice; Mol. Neurodegener.,?9?42 4) Hastings?et al.?(2017)?Inhibition of O-GlcNAcase leads to elevation of O-GlcNAc tau and reduction of tauopathy and cerebrospinal fluid tau in rTg4510 mice;?Mol. Neurodegener.,?12?39

Thiamet G Discontinued Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 118)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795 ivan@atkchemical.com China 32957 60
BOC Sciences
+1-631-485-4226 inquiry@bocsci.com United States 19553 58
career henan chemical co
+86-0371-86658258 +8613203830695 factory@coreychem.com China 29811 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32161 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD
86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6312 58
ANHUI WITOP BIOTECH CO., LTD
+8615255079626 eric@witopchemical.com China 23541 58
Shenzhen Shengda Pharma Limited
755-85269922 +8613424394241 sales@shengdapharm.com CHINA 310 58
Zhejiang J&C Biological Technology Co.,Limited
+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10473 58
InvivoChem
+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
Nantong HI-FUTURE Biology Co., Ltd.
+undefined18051384581 sales@chemhifuture.com China 3135 58

View Lastest Price from Thiamet G Discontinued manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Thiamet G pictures 2024-11-19 Thiamet G
1009816-48-1
US $37.00-94.00 / mg 99.76% 10g TargetMol Chemicals Inc.
Thiamet GDiscontinued pictures 2020-03-05 Thiamet G Discontinued
1009816-48-1
US $1.00 / KG 1KG 99% 200kg Career Henan Chemical Co
Thiamet G pictures 2020-02-07 Thiamet G
1009816-48-1
US $9.80 / KG 1KG >98%HPLC 20 tons Career Henan Chemical Co
  • Thiamet G pictures
  • Thiamet G
    1009816-48-1
  • US $37.00-94.00 / mg
  • 99.76%
  • TargetMol Chemicals Inc.
  • Thiamet G pictures
  • Thiamet G
    1009816-48-1
  • US $9.80 / KG
  • >98%HPLC
  • Career Henan Chemical Co

Thiamet G Discontinued Spectrum

Thiamet G Discontinued Thiamet G 1,2-Dideoxy-2'-ethylamino-a-D-glucopyranoso-[2,1-d]-2'-thiazoline 2-(ethylaMino)-5-(hydroxyMethyl)-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d]thiazole-6,7-dio 5H-Pyrano[3,2-d]thiazole-6,7-diol, 2-(ethylamino)-3a,6,7,7a-tetrahydro-5-(hydroxymethyl)-, (3aR,5R,6S,7R,7aR)- (3aR,5R,6S,7R,7aR)-2-(ethylamino)-3a,6,7,7a-tetrahydro-5-(hydroxymethyl)-5H-Pyrano[3,2-d]thiazole-6,7-diol (3aR,5R,6S,7R,7aR)-2-(Ethylamino)-5-(hydroxymethyl)-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d]thiazole-6,7-diol Thiamet G0nDiscontinued CS-1700 (3aR,5R,6S,7R,7aR)-2-(ethylamino)-5-(hydroxymethyl)-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d][1,3]thiazole-6,7-diol Thiamet G_x000b_Discontinued Thiamet H 2-(ethylamino)-3aR,6S,7R,7aR-tetrahydro-5R-(hydroxymethyl)-5H-pyrano[3,2-d]thiazole-6,7-diol 1009816-48-1 Carbohydrates & Derivatives Inhibitors Intermediates & Fine Chemicals Pharmaceuticals Sulfur & Selenium Compounds API Intermediates