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Calindol Hydrochloride

Calindol Hydrochloride Structure
Calindol Hydrochloride structure
CAS No.
729610-18-8
Chemical Name:
Calindol Hydrochloride
Synonyms
Calindol Hydrochloride;(R)-2-[[[1-(1-Naphthyl)ethyl]aMino]Methyl]-1H-indole Hydrochloride;N-[(1R)-1-(1-Naphthalenyl)ethyl]-1H-indole-2-MethanaMine Hydrochloride;(R)-N-((1H-Indol-2-yl)methyl)-1-(naphthalen-1-yl)ethan-1-amine hydrochloride
CBNumber:
CB52486991
Molecular Formula:
C21H20ClN2
Molecular Weight:
335.8499
MDL Number:
MFCD18382212
MOL File:
729610-18-8.mol
Last updated:2024-11-07 21:39:59
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Calindol Hydrochloride Properties

Melting point 208-210?C (dec.)
storage temp. Refrigerator
solubility Chloroform (Slightly), Methanol (Slightly)
form Solid
color Off-White to Light Pink

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
NFPA 704
0
2 0

Calindol Hydrochloride price More Price(18)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 17575 Calindol (hydrochloride) ≥98% 729610-18-8 1mg $44 2024-03-01 Buy
Cayman Chemical 17575 Calindol (hydrochloride) ≥98% 729610-18-8 5mg $193 2024-03-01 Buy
Cayman Chemical 17575 Calindol (hydrochloride) ≥98% 729610-18-8 10mg $341 2024-03-01 Buy
Cayman Chemical 17575 Calindol (hydrochloride) ≥98% 729610-18-8 25mg $745 2024-03-01 Buy
TRC C148700 CalindolHydrochloride 729610-18-8 100mg $1135 2021-12-16 Buy
Product number Packaging Price Buy
17575 1mg $44 Buy
17575 5mg $193 Buy
17575 10mg $341 Buy
17575 25mg $745 Buy
C148700 100mg $1135 Buy

Calindol Hydrochloride Chemical Properties,Uses,Production

Description

Calindol is a phenylalkylamine calcimimetic that facilitates the activation of the calcium-sensing receptor (CaSR), a G protein-coupled receptor that triggers phosphatidylinositol (PI)-intracellular calcium signaling and, in some cell types, cell proliferation. It potently stimulates PI hydrolysis and proliferation through human CaSR (pEC50 values are 6.9 and 7.4, respectively) in the presence of calcium. Calindol directly interacts with CaSR in transmembrane domains and triggers PI hydrolysis less effectively in the absence of calcium, indicating that it is an allosteric modulator that cooperates with calcium to activate the CaSR. Calindol is used to study the properties and distribution of CaSR in different types of cells and tissues.

Chemical Properties

Off-White Solid

Uses

A new calcimimetic acting at the calcium sensing receptor; a positive allosteric modulator of the human Ca2+ receptor, activates an extracellular ligand-binding domain-deleted Rhodopsin-like seven-transmembrane structure in the absence of Ca2+.

in vitro

previous study found that calindol could display improved calcimimetic activity compared to its n2-(2-chloro-(or 4-fluoro-)benzyl)-n1-(1-(1-naphthyl)ethyl)-3-phenylpropane-1,2-diamine analogs as well as stereoselectivity. in the presence of 2 mm ca(2+), calindol was able to stimulate [(3)h]inositol phosphates accumulation with an ec(50) of 1.0+/-0.1 or 0.31+/-0.05 μm in cells expressing the rat or the human casr, respectively. therefore, such calcimimetic activities of this novel compound were shown to be because of a specific interaction with the casr [1].

References

[1] kessler, a. ,faure, h.,petrel, c., et al. n2-benzyl-n1-(1-(1-naphthyl)ethyl)-3-phenylpropane-1,2-diamines and conformationally restrained indole analogues: development of calindol as a new calcimimetic acting at the calcium sensing receptor. bioorganic & medicinal chemistry letters 14(12), 3345-3349 (2004).

Calindol Hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

Calindol Hydrochloride Suppliers

Global( 21)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32076 58
Aladdin Scientific 		+1-+1(833)-552-7181 sales@aladdinsci.com United States 52925 58
J & K SCIENTIFIC LTD. 010-82848833 400-666-7788 jkinfo@jkchemical.com China 96815 76
Chemsky（shanghai）International Co.,Ltd. 021-50135380 shchemsky@sina.com China 32321 50
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9806 58
BioPharmaMatrix,Inc. 0510-86010668 sales@biopharmamatrix.com China 4084 55
Shenzhen Polymeri Biochemical Technology Co., Ltd. +86-400-002-6226 +86-13028896684; sales@rrkchem.com China 57202 58
BOC Sciences -- info@bocsci.com USA 0 65
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11217 58
Bide Pharmatech Ltd. 400-1647117 13681763483 product02@bidepharm.com China 62163 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
Aladdin Scientific 		58
J & K SCIENTIFIC LTD. 76
Chemsky（shanghai）International Co.,Ltd. 50
Shanghai EFE Biological Technology Co., Ltd. 58
BioPharmaMatrix,Inc. 55
Shenzhen Polymeri Biochemical Technology Co., Ltd. 58
BOC Sciences 65
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
Bide Pharmatech Ltd. 58

View Lastest Price from Calindol Hydrochloride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Calindol hydrochloride pictures 2024-11-07 Calindol hydrochloride
729610-18-8
 US $44.00-259.00 / mg 99.47% 10g TargetMol Chemicals Inc.
(R)-2-[[[1-(1-Naphthyl)ethyl]aMino]Methyl]-1H-indole Hydrochloride N-[(1R)-1-(1-Naphthalenyl)ethyl]-1H-indole-2-MethanaMine Hydrochloride Calindol Hydrochloride (R)-N-((1H-Indol-2-yl)methyl)-1-(naphthalen-1-yl)ethan-1-amine hydrochloride 729610-18-8 C21H20N2HCl C21H20N2ClH Aromatics Chiral Reagents Indole Derivatives Intermediates & Fine Chemicals Pharmaceuticals