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ENMD 547
- CAS No.
- 644961-61-5
- Chemical Name:
- ENMD 547
- Synonyms
- ENMD 547;ENMD1068 HBr;ENMD-1068 HBr;ENMD 1068 HBr;ENMD-1068 Hydrobromide;6-AMino-1-[4-(3-Methyl-1-oxobutyl)-1-piperazinyl]-1-hexanone HydrobroMide;1-(6-AMino-1-oxohexyl)-4-(3-Methyl-1-oxobutyl)piperazine MonohydrobroMide
- CBNumber:
- CB52508228
- Molecular Formula:
- C15H30BrN3O2
- Molecular Weight:
- 364.3216
- MDL Number:
- MFCD18379409
- MOL File:
- 644961-61-5.mol
ENMD 547 Chemical Properties,Uses,Production
Uses
A selective PAR-2 antagonist. Dose dependently inhibits calcium signaling in Lewis lung carcinoma cells stimulated with a soluble peptide PAR-2 agonist or trypsin, but not with a soluble PAR-1 agonist. Does not inhibit platelet aggregation stimulated by thrombin suggesting that it does not inhibit PAR-3 or PAR-4 signaling. Reduces TNF-a and IL-1β production from rheumatoid arthritis synovial primary cell culture and reduces joint swelling in a carageenan/kaloin-injected mouse model.
Uses
ENMD 547 can be used as a selective PAR-2 antagonist. Dose dependently inhibits calcium signaling in Lewis lung carcinoma cells stimulated with a soluble peptide PAR-2 agonist or trypsin, but not with a soluble PAR-1 agonist.
ENMD 547 Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 19)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd | +86-18341751992 +86-15382112998 | 757984502@qq.com | China | 892 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15421 | 60 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9707 | 58 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 13028896684 | sales@rrkchem.com | China | 56068 | 58 |
| ShangHai ChuanQian Chemcial Technique Centre | 15869524721 | 3525679403@qq.com | China | 3670 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44941 | 58 |
| Changzhou Furuisi Biotechnology Co., Ltd | 0519-85524369 | 3477467573@qq.com | China | 8618 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24017 | 58 |
ENMD 547
1-(6-AMino-1-oxohexyl)-4-(3-Methyl-1-oxobutyl)piperazine MonohydrobroMide
6-AMino-1-[4-(3-Methyl-1-oxobutyl)-1-piperazinyl]-1-hexanone HydrobroMide
ENMD-1068 Hydrobromide
ENMD 1068 HBr
ENMD1068 HBr
ENMD-1068 HBr
644961-61-5
C15H30BrN3O2
Amines
Heterocycles
Intermediates & Fine Chemicals
Pharmaceuticals