ENMD 547
- CAS No.
- 644961-61-5
- Chemical Name:
- ENMD 547
- Synonyms
- ENMD 547;ENMD1068 HBr;ENMD-1068 HBr;ENMD 1068 HBr;ENMD-1068 Hydrobromide;6-AMino-1-[4-(3-Methyl-1-oxobutyl)-1-piperazinyl]-1-hexanone HydrobroMide;1-(6-AMino-1-oxohexyl)-4-(3-Methyl-1-oxobutyl)piperazine MonohydrobroMide
- CBNumber:
- CB52508228
- Molecular Formula:
- C15H30BrN3O2
- Molecular Weight:
- 364.3216
- MDL Number:
- MFCD18379409
- MOL File:
- 644961-61-5.mol
ENMD 547 Chemical Properties,Uses,Production
Uses
A selective PAR-2 antagonist. Dose dependently inhibits calcium signaling in Lewis lung carcinoma cells stimulated with a soluble peptide PAR-2 agonist or trypsin, but not with a soluble PAR-1 agonist. Does not inhibit platelet aggregation stimulated by thrombin suggesting that it does not inhibit PAR-3 or PAR-4 signaling. Reduces TNF-a and IL-1β production from rheumatoid arthritis synovial primary cell culture and reduces joint swelling in a carageenan/kaloin-injected mouse model.
Uses
ENMD 547 can be used as a selective PAR-2 antagonist. Dose dependently inhibits calcium signaling in Lewis lung carcinoma cells stimulated with a soluble peptide PAR-2 agonist or trypsin, but not with a soluble PAR-1 agonist.
ENMD 547 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32159 | 58 |
| Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd | +86-18341751992 +86-15382112998 | 757984502@qq.com | China | 892 | 58 |
| TargetMol Chemicals Inc. | +8613564774135 | zijue.cai@tsbiochem.com | United States | 19881 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15402 | 60 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9804 | 58 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 +86-13028896684; | sales@rrkchem.com | China | 57422 | 58 |
| ShangHai ChuanQian Chemcial Technique Centre | 15869524721 | 3525679403@qq.com | China | 4350 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44918 | 58 |
| Changzhou Furuisi Biotechnology Co., Ltd | 0519-85524369 | 3477467573@qq.com | China | 8617 | 58 |
View Lastest Price from ENMD 547 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-10-28 | ENMD-1068 HBr
644961-61-5
|
US $1980.00-1520.00 / mg | 10g | TargetMol Chemicals Inc. |
-
- ENMD-1068 HBr
644961-61-5
- US $1980.00-1520.00 / mg
- TargetMol Chemicals Inc.