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ON-01910

ON-01910 Structure
ON-01910 structure
CAS No.
1225497-78-8
Chemical Name:
ON-01910
Synonyms
CS-551;Estybon;ON-01910;Rigosertio;ON-01910;ESTYBON;ON-01910 USP/EP/BP;on 1910 sodium salt;ON 01910 sodium salt;brand name: Estybon.;Rigosertib (ON-01910)
CBNumber:
CB52514041
Molecular Formula:
C21H26NNaO8S
Molecular Weight:
475.49
MDL Number:
MFCD11655911
MOL File:
1225497-78-8.mol
MSDS File:
SDS
Last updated:2024-11-17 16:00:36
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ON-01910 Properties

Melting point >256oC (dec.)
storage temp. Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility Methanol (Slightly), Water (Slightly)
form Solid
color Pale Yellow to Pale Green
NCI Drug Dictionary Estybon

ON-01910 price More Price(15)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 15553 ON-01910 (sodium salt) ≥98% 1225497-78-8 1mg $34 2024-03-01 Buy
Cayman Chemical 15553 ON-01910 (sodium salt) ≥98% 1225497-78-8 5mg $85 2024-03-01 Buy
Cayman Chemical 15553 ON-01910 (sodium salt) ≥98% 1225497-78-8 10mg $150 2024-03-01 Buy
Cayman Chemical 15553 ON-01910 (sodium salt) ≥98% 1225497-78-8 25mg $330 2024-03-01 Buy
TRC O657000 ON-01910SodiumSalt 1225497-78-8 25mg $250 2021-12-16 Buy
Product number Packaging Price Buy
15553 1mg $34 Buy
15553 5mg $85 Buy
15553 10mg $150 Buy
15553 25mg $330 Buy
O657000 25mg $250 Buy

ON-01910 Chemical Properties,Uses,Production

Uses

Rigosertib (ON-01910) is a non-ATP-competitive inhibitor of Polo-like kinase 1 (PLK1).

Definition

ChEBI: Rigosertib sodium is the sodium salt of rigosertib. It is an anti-cancer agent which has been granted Orphan Drug Designation by the FDA for use in patients with myelodysplastic syndromes (MDS). It has a role as a microtubule-destabilising agent, an antineoplastic agent, an EC 2.7.11.21 (polo kinase) inhibitor and an apoptosis inducer. It contains a rigosertib(1-).

Biological Activity

rigosertib (on-01910,estybon) is a potent, specific plk1 inhibitor with ic50 value of 9nm. rigosertib strongly inhibited the proliferation of cancer cell lines, with observed ic50 values in the nanomolar range for both hela (115 nm) and c33a (45 nm) cells. in contrast, rigosertib had a minimal effect on normal cell lines, bj and ect1/e6e7 (ic50 > 0.1 mm) [1]hela and c33a cells demonstrated a complete (>95%) g2/m arrest at concentrations of rigosertib >0.5 μm, whereas atrigosertib has been reported to be a more potent radiosensitizer than cisplatin in vivo [1].

References

[1] agoni l1, basu i2, gupta s3, alfieri a2, gambino a4, goldberg gl5, reddy ep6, guha c7.rigosertib is a more effective radiosensitizer than cisplatin in concurrent chemoradiation treatment of cervical carcinoma, in vitro and in vivo. int j radiat oncol biol phys. 2014 apr 1;88(5):1180-7.

ON-01910 Preparation Products And Raw materials

Raw materials

Preparation Products

ON-01910 Suppliers

Global( 96)Suppliers
Supplier Tel Email Country ProdList Advantage
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19553 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49374 58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 		+8613580539051 joe@yuhengpharm.com CHINA 21142 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32165 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6312 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1026@dideu.com China 22883 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10473 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
LEAP CHEM CO., LTD. 		+86-852-30606658 market18@leapchem.com China 24727 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38632 58
Supplier Advantage
BOC Sciences 		58
CONIER CHEM AND PHARMA LIMITED 		58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 		58
TargetMol Chemicals Inc. 		58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		58
Dideu Industries Group Limited 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
InvivoChem 		58
LEAP CHEM CO., LTD. 		58
TargetMol Chemicals Inc. 		58

View Lastest Price from ON-01910 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
(E/Z)-Rigosertib sodium pictures 2024-11-17 (E/Z)-Rigosertib sodium
1225497-78-8
 US $34.00-97.00 / mg 99.82% 10g TargetMol Chemicals Inc.

ON-01910 Spectrum

ON-01910(1225497-78-8)1HNMR

1225497-78-8(ON-01910)Related Search:

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Volasertib (BI 6727)

1of3

ON-01910 Estybon N-[2-Methoxy-5-[[[2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonyl]methyl]phenyl]glycine sodium salt ON 01910 sodium salt ON-01910;ESTYBON Rigosertib (ON-01910) N-[2-methoxy-5-[[[2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonyl]methyl]phenyl]-glycine,sodium salt (1:1) N-[2-Methoxy-5-[[[2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonyl]methyl]phenyl]glycine sodium salt Rigosertib (ON-01910) sodium 2-((2-methoxy-5-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)phenyl)amino)acetate||| Sodium (E)-2-((2-methoxy-5-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)phenyl)amino)acetate Rigosertib Sodium(Random Configuration) Rigosertib, ON 01910 sodium salt brand name: Estybon. ON01910; ON 01910; ON-01910; RIGOSERTIB SODIUM; BRAND NAME: ESTYBON. Rigosertio Rigosertib sodium salt ON-01910; ON01910; ON 01910 ON-01910 (rigosertib) CS-551 on 1910 sodium salt 2-[2-methoxy-5-[2-(2,4,6-trimethoxyphenyl)vinylsulfonylmethyl]anilino]acetic acid ON-01910 USP/EP/BP Sodium (2-methoxy-5-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)phenyl)glycinate Rigosertib sodium (ON-01910) (E/Z)-Rigosertib sodium 1225497-78-8 C21H24NO8SNa Inhibitors API