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4-[4-(4-Fluorophenyl)-1-(3-phenylpropyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]-3-butyn-1-ol

4-[4-(4-Fluorophenyl)-1-(3-phenylpropyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]-3-butyn-1-ol structure

CAS No.: 215303-72-3

Chemical Name:: 4-[4-(4-Fluorophenyl)-1-(3-phenylpropyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]-3-butyn-1-ol

Synonyms: CS-1470;RWJ 67657;JNJ 3026582;RWJ-67657;JNJ-3026582;RWJ-67657; RWJ-67657; RWJ-67657;4-[4-(4-fluorophenyl)-1-(3-phenylpropyl)-5-pyridin-4-ylimidazol-2-yl]but-3-yn-1-ol;4-(4-Fluorophenyl)-2-(4-hydroxy-1-butynyl)-1-(3-phenylpropyl)-5-(4-Pyridyl)iMidazole;4-[4-(4-Fluorophenyl)-1-(3-phenylpropyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]-3-butyn-1-ol;4-(4-(4-fluorophenyl)-1-(3-phenylpropyl)-5-(pyridin-4-yl)-1H-imidazol-2-yl)but-3-yn-1-ol;3-Butyn-1-ol, 4-[4-(4-fluorophenyl)-1-(3-phenylpropyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]-

CBNumber:: CB52518847

Molecular Formula:: C27H24FN3O

Molecular Weight:: 425.5

MDL Number:: MFCD11840606

MOL File:: 215303-72-3.mol

MSDS File:: SDS

Last updated:2024-11-19 20:33:22

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4-[4-(4-Fluorophenyl)-1-(3-phenylpropyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]-3-butyn-1-ol Properties

Melting point	124℃
Boiling point	611.8±65.0 °C(Predicted)
Density	1.14±0.1 g/cm3(Predicted)
storage temp.	Store at RT
solubility	≤10mg/ml in ethanol;5mg/ml in DMSO;2mg/ml in dimethyl formamide
pka	14.37±0.10(Predicted)
form	Yellow powder.
color	Light yellow to yellow
FDA UNII	MXN26D3ZUN

4-[4-(4-Fluorophenyl)-1-(3-phenylpropyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]-3-butyn-1-ol price More Price(24)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	SML2212	RWJ 67657 ≥98% (HPLC)	215303-72-3	5MG	$56.52	2024-03-01	Buy
Sigma-Aldrich	SML2212	RWJ 67657 ≥98% (HPLC)	215303-72-3	25MG	$319	2024-03-01	Buy
Cayman Chemical	18718	RWJ 67657 ≥95%	215303-72-3	1mg	$44	2024-03-01	Buy
Cayman Chemical	18718	RWJ 67657 ≥95%	215303-72-3	5mg	$87	2024-03-01	Buy
Cayman Chemical	18718	RWJ 67657 ≥95%	215303-72-3	10mg	$117	2024-03-01	Buy

Product number	Packaging	Price	Buy
SML2212	5MG	$56.52	Buy
SML2212	25MG	$319	Buy
18718	1mg	$44	Buy
18718	5mg	$87	Buy
18718	10mg	$117	Buy

4-[4-(4-Fluorophenyl)-1-(3-phenylpropyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]-3-butyn-1-ol Chemical Properties,Uses,Production

Uses

RWJ-67657 is a p38 mitogen-activated protein-kinase (p38MAPK) inhibitor. Studies show that RWJ-67657 might provide a useful tool to intervene in the deranged immune response in sepsis and other inflammatory diseases. RWJ 67657 has been shown to inhibit chemokine production and E-selectin expression in activated endothelial cells,

Biological Activity

rwj 67657 is an orally active inhibitor of the map kinases p38α and p38β.tumor necrosis factor-alpha (tnf-alpha), a cytokine secreted by activated monocytes/macrophages and t lymphocytes, is implicated in several disease states, such as inflammatory bowel disease, rheumatoid arthritis, septic shock, as well as osteoporosis. the monocyte/macrophage production of tnf-alpha is dependent on the mitogen-activated protein kinase p38.

in vitro

rwj 67657 could inhibit the release of tnf-alpha by lipopolysaccharide-treated human peripheral blood mononuclear cells, as well as the release of tnf-alpha from peripheral blood mononuclear cells treated with the superantigen staphylococcal enterotoxin b. rwj 67657 was about 10-fold more potent than the literature standard p38 kinase inhibitor sb 203580 in all tested p38 dependent in-vitro systems tested. moreover, rwj 67657 was able to inhibit the enzymatic activity of recombinant p38alpha and beta, but not gamma or delta, and showed no significant activity against various other enzymes. in contrast, sb 203580 could significantly inhibit the tyrosine kinases p56 lck and c-src. in addition, rwj 67657 did not inhibit t cell production of interleukin-2 or interferon-gamma and did not inhibit t cell proliferation in response to mitogens [1].

in vivo

animal study found that rwj 67657 could inhibit tnf-alpha production in lipopolysaccharide-injected mice (87% inhibition at 50 mg/kg) and in rats (91% inhibition at 25 mg/kg) after oral administration [1].

IC 50

1 and 11 μm for p38α and p38β, respectively

storage

Room temperature

References

[1] wadsworth, s. a.,cavender, d.e.,beers, s.a., et al. rwj 67657, a potent, orally active inhibitor of p38 mitogen-activated protein kinase. journal of pharmacology and experimental therapeutics 291(2), 680-687 (1999).

4-[4-(4-Fluorophenyl)-1-(3-phenylpropyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]-3-butyn-1-ol Preparation Products And Raw materials

Raw materials

Preparation Products

4-[4-(4-Fluorophenyl)-1-(3-phenylpropyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]-3-butyn-1-ol Suppliers

Global( 84)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32957	60
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28172	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32165	58
ANHUI WITOP BIOTECH CO., LTD	+8615255079626	eric@witopchemical.com	China	23541	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	22783	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	trendseenbio@gmail.com	China	11681	58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd	+86-18341751992 +86-15382112998	757984502@qq.com	China	892	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	57505	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131957	58
Shanghai Boyle Chemical Co., Ltd.		sales@boylechem.com	China	2922	55

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
Hubei Jusheng Technology Co.,Ltd.	58
TargetMol Chemicals Inc.	58
ANHUI WITOP BIOTECH CO., LTD	58
Dideu Industries Group Limited	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd	58
Aladdin Scientific	58
Amadis Chemical Company Limited	58
Shanghai Boyle Chemical Co., Ltd.	55

View Lastest Price from 4-[4-(4-Fluorophenyl)-1-(3-phenylpropyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]-3-butyn-1-ol manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2024-11-19	RWJ-67657 215303-72-3	US $39.00-97.00 / mg		99.66%	10g	TargetMol Chemicals Inc.
	2021-09-29	4-[4-(4-Fluorophenyl)-1-(3-phenylpropyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]-3-butyn-1-ol 215303-72-3	US $1.10 / g	1g	99.00%	100 Tons Min	Dideu Industries Group Limited

RWJ-67657
215303-72-3
US $39.00-97.00 / mg
99.66%
TargetMol Chemicals Inc.

4-[4-(4-Fluorophenyl)-1-(3-phenylpropyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]-3-butyn-1-ol
215303-72-3
US $1.10 / g
99.00%
Dideu Industries Group Limited

215303-72-3(4-[4-(4-Fluorophenyl)-1-(3-phenylpropyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]-3-butyn-1-ol)Related Search:

2'-Hydroxyacetophenone Dihydrocaffeic acid Dihydroxybenzoic acid

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