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ChemicalBook >> CAS DataBase List >>N-[1,1'-Biphenyl]-2-yl-1-[2-[(1-methyl-1H-benzimidazol-2-yl)thio]acetyl-2-pyrrolidinedicarboxamide

N-[1,1'-Biphenyl]-2-yl-1-[2-[(1-methyl-1H-benzimidazol-2-yl)thio]acetyl-2-pyrrolidinedicarboxamide

N-[1,1'-Biphenyl]-2-yl-1-[2-[(1-methyl-1H-benzimidazol-2-yl)thio]acetyl-2-pyrrolidinedicarboxamide Structure
N-[1,1'-Biphenyl]-2-yl-1-[2-[(1-methyl-1H-benzimidazol-2-yl)thio]acetyl-2-pyrrolidinedicarboxamide structure
CAS No.
916141-36-1
Chemical Name:
N-[1,1'-Biphenyl]-2-yl-1-[2-[(1-methyl-1H-benzimidazol-2-yl)thio]acetyl-2-pyrrolidinedicarboxamide
Synonyms
CS-916;TCS-102;TCS 1102;TCS1102; TCS-1102;TCS 1102 , CID11960895;N-2-Biphenylyl-1-{[(1-methyl-1H-benzimidazol-2-yl)sulfanyl]acetyl }-L-prolinamide;(2S)-1-[2-(1-METHYLBENZIMIDAZOL-2-YL)SULFANYLACETYL]-N-(2-PHENYLPHENYL)PYRROLIDINE-2-CARBOXAMIDE;N-[1,1'-Biphenyl]-2-yl-1-[2-[(1-methyl-1H-benzimidazol-2-yl)thio]acetyl-2-pyrrolidinedicarboxamide;N-[1,1'-Biphenyl]-2-yl-1-[2-[(1-methyl-1H-benzimidazol-2-yl)thio]acetyl-2-pyrrolidinedicarboxamide;(2S)-N-[1,1'-Biphenyl]-2-yl-1-[2-[(1-methyl-1H-benzimidazol-2-yl)thio]acetyl]-2-pyrrolidinecarboxamide
CBNumber:
CB52518973
Molecular Formula:
C27H26N4O2S
Molecular Weight:
470.59
MDL Number:
MFCD18086894
MOL File:
916141-36-1.mol
MSDS File:
SDS
Last updated:2024-11-19 23:02:33
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N-[1,1'-Biphenyl]-2-yl-1-[2-[(1-methyl-1H-benzimidazol-2-yl)thio]acetyl-2-pyrrolidinedicarboxamide Properties

storage temp. Sealed in dry,2-8°C
solubility DMF: 25 mg/ml; DMF:PBS (pH 7) (1:10): 0.09 mg/ml; DMSO: 14 mg/ml; Ethanol: 10 mg/ml
form Powder
color White to off-white

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H317
Precautionary statements  P280-P305+P351+P338

N-[1,1'-Biphenyl]-2-yl-1-[2-[(1-methyl-1H-benzimidazol-2-yl)thio]acetyl-2-pyrrolidinedicarboxamide price More Price(20)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 18495 TCS 1102 ≥98% 916141-36-1 1mg $32 2024-03-01 Buy
Cayman Chemical 18495 TCS 1102 ≥98% 916141-36-1 5mg $100 2024-03-01 Buy
Cayman Chemical 18495 TCS1102 ≥98% 916141-36-1 25mg $305 2024-03-01 Buy
Cayman Chemical 18495 TCS 1102 ≥98% 916141-36-1 10mg $169 2024-03-01 Buy
Tocris 3818 TCS1102 ≥98%(HPLC) 916141-36-1 10 $176 2021-12-16 Buy
Product number Packaging Price Buy
18495 1mg $32 Buy
18495 5mg $100 Buy
18495 25mg $305 Buy
18495 10mg $169 Buy
3818 10 $176 Buy

N-[1,1'-Biphenyl]-2-yl-1-[2-[(1-methyl-1H-benzimidazol-2-yl)thio]acetyl-2-pyrrolidinedicarboxamide Chemical Properties,Uses,Production

Description

Orexin receptors 1 (OX1R) and OX2R mediate the action of the neuropeptides orexin A and orexin B. TCS 1102 is a dual antagonist of both OX1R and OX2R (Kis = 0.2 and 3 nM, respectively). It is a poor substrate for P-glycoprotein and, as a result, demonstrates good brain penetration when administered intraperitoneally. Dual orexin receptor antagonists, including TCS 1102, promote sleep and prevent drug-induced plasticity and drug relapse. Systemic injection of TCS 1102 (10 mg/kg i.p.) in rats decreases fear and anxiety in response to acute episodes of stress.

Uses

TCS 1102 is a dual antagonist of both OX1R and OX2R. It is a poor substrate for P-glycoprotein and, as a result, demonstrates good brain penetration when administered intraperitoneally. Dual orexin receptor antagonists, including TCS 1102, promote sleep and prevent drug-induced plasticity and drug relapse.

storage

Store at RT

N-[1,1'-Biphenyl]-2-yl-1-[2-[(1-methyl-1H-benzimidazol-2-yl)thio]acetyl-2-pyrrolidinedicarboxamide Preparation Products And Raw materials

Raw materials

Preparation Products

N-[1,1'-Biphenyl]-2-yl-1-[2-[(1-methyl-1H-benzimidazol-2-yl)thio]acetyl-2-pyrrolidinedicarboxamide Suppliers

Global( 69)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32957 60
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29811 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32165 58
Hefei Hirisun Pharmatech Co., Ltd 		+8615056975894 shawn@hirisunpharm.com CHINA 9911 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10473 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
Aladdin Scientific 		+1-+1(833)-552-7181 sales@aladdinsci.com United States 57505 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131957 58
Shanghai Boyle Chemical Co., Ltd. sales@boylechem.com China 2922 55
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037 3bsc@sina.com China 15839 69
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
TargetMol Chemicals Inc. 		58
Hefei Hirisun Pharmatech Co., Ltd 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
InvivoChem 		58
Aladdin Scientific 		58
Amadis Chemical Company Limited 		58
Shanghai Boyle Chemical Co., Ltd. 55
3B Pharmachem (Wuhan) International Co.,Ltd. 69

View Lastest Price from N-[1,1'-Biphenyl]-2-yl-1-[2-[(1-methyl-1H-benzimidazol-2-yl)thio]acetyl-2-pyrrolidinedicarboxamide manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
TCS 1102 pictures 2024-11-19 TCS 1102
916141-36-1
 US $34.00-106.00 / mg 99.52% 10g TargetMol Chemicals Inc.
TCS 1102 pictures 2020-02-06 TCS 1102
916141-36-1
 US $1.00 / KG 1KG Min98% HPLC g/kg/ton Career Henan Chemical Co
  • TCS 1102 pictures
  • TCS 1102
    916141-36-1
  • US $34.00-106.00 / mg
  • 99.52%
  • TargetMol Chemicals Inc.
  • TCS 1102 pictures
  • TCS 1102
    916141-36-1
  • US $1.00 / KG
  • Min98% HPLC
  • Career Henan Chemical Co

N-[1,1'-Biphenyl]-2-yl-1-[2-[(1-methyl-1H-benzimidazol-2-yl)thio]acetyl-2-pyrrolidinedicarboxamide Spectrum

N-[1,1'-Biphenyl]-2-yl-1-[2-[(1-methyl-1H-benzimidazol-2-yl)thio]acetyl-2-pyrrolidinedicarboxamide(916141-36-1)1HNMR

916141-36-1(N-[1,1'-Biphenyl]-2-yl-1-[2-[(1-methyl-1H-benzimidazol-2-yl)thio]acetyl-2-pyrrolidinedicarboxamide)Related Search:

TC-O 9311 TC-2153
(2S)-N-[1,1'-Biphenyl]-2-yl-1-[2-[(1-methyl-1H-benzimidazol-2-yl)thio]acetyl]-2-pyrrolidinecarboxamide TCS-102 (2S)- 2-Pyrrolidinecarboxamide, N-[1,1'-biphenyl]-2-yl-1-[2-[(1-methyl-1H-benzimidazol-2-yl)thio]acetyl] 2-PyrrolidinecarboxaMide, N-[1,1'-biphenyl]-2-yl-1-[2-[(1-Methyl-1H-benziMidazol-2-yl)thio]acetyl]-, (2S)- (2S)-N-[1,1'-Biphenyl]-2-yl-1-[2-[(1-methyl-1H-benzimidazol-2-yl)thio]acetyl]-2-pyrrolidinecarboxamide TCS1102 TCS 1102 N-[1,1'-Biphenyl]-2-yl-1-[2-[(1-methyl-1H-benzimidazol-2-yl)thio]acetyl-2-pyrrolidinedicarboxamide N-[1,1'-Biphenyl]-2-yl-1-[2-[(1-methyl-1H-benzimidazol-2-yl)thio]acetyl-2-pyrrolidinedicarboxamide TCS 1102 (2S)-1-[2-(1-METHYLBENZIMIDAZOL-2-YL)SULFANYLACETYL]-N-(2-PHENYLPHENYL)PYRROLIDINE-2-CARBOXAMIDE TCS 1102 , CID11960895 CS-916 TCS1102; TCS-1102 N-2-Biphenylyl-1-{[(1-methyl-1H-benzimidazol-2-yl)sulfanyl]acetyl }-L-prolinamide TCS-1102,pharmacodynamic model,inhibit,TCS1102,orexin,central activity,Orexin Receptor (OX Receptor),post-traumatic stress disorder,TCS 1102,HCRT Receptor,Hypocretin Receptor,Inhibitor,T-maze,hypocretin,fear,anxiety (S)-N-([1,1'-Biphenyl]-2-yl)-1-(2-((1-methyl-1H-benzo[d]imidazol-2-yl)thio)acetyl)pyrrolidine-2-carboxamide N-[1,1'-Biphenyl]-2-yl-1-[2-[(1-methyl-1H-benzimidazol-2-yl)thio]acetyl-2-pyrrolidinedicarboxamide (S)-N-([1,1'-Biphenyl]-2-yl)-1-(2-((1-methyl-1H-benzo[d]imidazol-2-yl)thio)acetyl)pyrrolidine-2-carboxamide (2S)-N-{[1,1'-biphenyl]-2-yl}-1-{2-[(1-methyl-1H-1,3-benzodiazol-2-yl)sulfanyl]acetyl}pyrrolidine-2-carboxamide 916141-36-1 Inhibitors