PCI 34051
- CAS No.
- 950762-95-5
- Chemical Name:
- PCI 34051
- Synonyms
- PCI-34051;PCI 34051;PCI-34051;PCI 34051;PCI-34051, 10 mM in DMSO;N-hydroxy-1-(4-Methoxybenzyl)-1H-indole-6-carboxaMide;1-(4-methoxybenzyl)-N-hydroxy-1H-indole-6-carboxamide;N-hydroxy-1-[(4-methoxyphenyl)methyl]indole-6-carboxamide;N-Hydroxy-1-[(4-methoxyphenyl)methyl]-1H-indole-6-carboxamide;1H-Indole-6-carboxamide, N-hydroxy-1-[(4-methoxyphenyl)methyl]-
- CBNumber:
- CB52622953
- Molecular Formula:
- C17H16N2O3
- Molecular Weight:
- 296.32
- MDL Number:
- MFCD11114393
- MOL File:
- 950762-95-5.mol
- MSDS File:
- SDS
| Density | 1.25 |
|---|---|
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| solubility | insoluble in H2O; insoluble in EtOH; ≥14.8 mg/mL in DMSO |
| form | Powder |
| pka | 9.16±0.30(Predicted) |
| color | White to gray |
| FDA UNII | PUI52VXV61 |
PCI 34051 price More Price(27)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 10444 | PCI 34051 ≥95% | 950762-95-5 | 5mg | $77 | 2024-03-01 | Buy |
| Cayman Chemical | 10444 | PCI 34051 ≥95% | 950762-95-5 | 10mg | $144 | 2024-03-01 | Buy |
| Cayman Chemical | 10444 | PCI 34051 ≥95% | 950762-95-5 | 50mg | $602 | 2024-03-01 | Buy |
| Cayman Chemical | 10444 | PCI 34051 ≥95% | 950762-95-5 | 100mg | $829 | 2024-03-01 | Buy |
| Tocris | 4643 | PCI34051 ≥98%(HPLC) | 950762-95-5 | 50 | $471 | 2021-12-16 | Buy |
PCI 34051 Chemical Properties,Uses,Production
Uses
PCI-34051 is a potent, histone deacetylase 8 (HDAC8)-specific inhibitor. PCI-34051 induces caspase-dependent apoptosis in cell lines derived from T-cell lymphomas or leukemias. PCI-34051 did not affect other hematopoietic or solid tumor lines. PCI-34051 treatment has been shown to significantly reduce cholesterol accumulation in Niemann-Pick type C1 gene mutated human fibroblast.
Definition
ChEBI: N-hydroxy-1-[(4-methoxyphenyl)methyl]-6-indolecarboxamide is an indolecarboxamide.
Biological Activity
pci-34051 is a potent, specific inhibitor of histone deacetylase 8 (hdac8) with greater than 200-fold selectivity over the other hdac isoforms, such as 1, 2, 3, 6 and 10. it induces caspase dependent apoptosis in cell lines derived from t-cell lymphomas or leukemias, but not in other hematopoietic or solid tumor lines. pci-34051 does not cause detectable histone or tubulin acetylation and also does not inhibit growth or induce apoptosis in normal cells such as pbmcs or fibroblasts. although a phospholipase c-gamma1 (plcgamma1) defective line is resistant, cells defective in t-cell receptor signaling are still sensitive to pci-34051 induced apoptosis.
in vivo
Administration of PCI-34051 and Dexamethasone reduces the eosinophilic inflammation and airway hyperresponsiveness in asthma to reduce the airway remodeling[2].
IC 50
HDAC8: 10 nM (IC50); HDAC6: 2.9 μM (IC50); HDAC1: 4 μM (IC50); HDAC10: 13 μM (IC50)
storage
-20°C
PCI 34051 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 965 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22963 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29808 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32202 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24727 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38636 | 58 | |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
View Lastest Price from PCI 34051 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-19 | PCI-34051
950762-95-5
|
US $55.00-195.00 / mg | 99.14% | 10g | TargetMol Chemicals Inc. | ||
![N-hydroxy-1-[(4-methoxyphenyl)methyl]indole-6-carboxamide pictures](https://img.chemicalbook.com/ProductImageEN/2019-12/Small/6071f2ba-f93d-486f-9cdb-74f52151c90f.png) |
2019-12-24 | N-hydroxy-1-[(4-methoxyphenyl)methyl]indole-6-carboxamide
950762-95-5
|
US $1.00 / KG | 1KG | Min98% HPLC | g/kg/ton | Career Henan Chemical Co | |
![N-hydroxy-1-[(4-methoxyphenyl)methyl]indole-6-carboxamide pictures](https://img.chemicalbook.com/ProductImageEN/2019-12/Small/6fe7ce67-2ff7-463f-8bd4-313145366791.png) |
2019-12-23 | N-hydroxy-1-[(4-methoxyphenyl)methyl]indole-6-carboxamide
950762-95-5
|
US $1.00 / KG | 1KG | Min98% HPLC | g/kg/ton | Career Henan Chemical Co |
-
- PCI-34051
950762-95-5
- US $55.00-195.00 / mg
- 99.14%
- TargetMol Chemicals Inc.
-
- N-hydroxy-1-[(4-methoxyphenyl)methyl]indole-6-carboxamide
950762-95-5
- US $1.00 / KG
- Min98% HPLC
- Career Henan Chemical Co
-
- N-hydroxy-1-[(4-methoxyphenyl)methyl]indole-6-carboxamide
950762-95-5
- US $1.00 / KG
- Min98% HPLC
- Career Henan Chemical Co