5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde
- CAS No.
- 881674-56-2
- Chemical Name:
- 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde
- Synonyms
- 5-(2-fluorophenyl)-1H-pyrrole-3-carbaldehyde;5-(2-Fluorophenyl)-1H-pyrrole-3-carboxaldehyde;5-(2-Fluorophenyl)pyrrole-3-carboxaldehyde;Vonorazan;VONOPRAZAN IST-1;5-(2-FL;e-3-carbaL;)-1H-pyrroL;Vonoprazan-1;Vonoprazan-023
- CBNumber:
- CB52638918
- Molecular Formula:
- C11H8FNO
- Molecular Weight:
- 189.19
- MDL Number:
- MFCD11875867
- MOL File:
- 881674-56-2.mol
- MSDS File:
- SDS
| Melting point | 133 °C |
|---|---|
| Boiling point | 370.6±32.0 °C(Predicted) |
| Density | 1.270±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | Chloroform (Slightly, Sonicated), DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 14.77±0.50(Predicted) |
| color | Light Brown to Brown |
| Stability | Hygroscopic |
| InChI | InChI=1S/C11H8FNO/c12-10-4-2-1-3-9(10)11-5-8(7-14)6-13-11/h1-7,13H |
| InChIKey | MQULPEUCGKEHEG-UHFFFAOYSA-N |
| SMILES | N1C(C2=CC=CC=C2F)=CC(C=O)=C1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H319-H302+H312+H332-H315 |
| Precautionary statements | P280-P301+P312-P362+P364 |
| HS Code | 2933998090 |
5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde price More Price(20)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | F1074 | 5-(2-Fluorophenyl)pyrrole-3-carboxaldehyde >98.0%(GC) | 881674-56-2 | 1g | $98 | 2024-03-01 | Buy |
| TCI Chemical | F1074 | 5-(2-Fluorophenyl)pyrrole-3-carboxaldehyde >98.0%(GC) | 881674-56-2 | 5g | $295 | 2024-03-01 | Buy |
| TRC | F489655 | 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde | 881674-56-2 | 1g | $105 | 2021-12-16 | Buy |
| TRC | F489655 | 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde | 881674-56-2 | 250mg | $50 | 2021-12-16 | Buy |
| ChemScene | CS-W004473 | 5-(2-fluorophenyl)-1H-pyrrole-3-carbaldehyde 99.96% | 881674-56-2 | 10g | $67 | 2021-12-16 | Buy |
5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde Chemical Properties,Uses,Production
Description
5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde is an ether. It can be used to prepare vonoprazan fumarate, which is a potent orally active potassium-competitive acid blocker (P-CAB) with antisecretory activity. It is used in the study of acid-related diseases.
Chemical Properties
Light orange to Yellow to Green powder to crystal.
Uses
5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde acts as a reagent in the synthetic preparation of novel pyrrole derivatives as potassium-competitive acid blocker (P-CAB).
Application
5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde is a potassium ion-competitive acid blocker used in therapy Acid-related diseases, gastric ulcer, duodenal ulcer, reflux esophagitis, etc.
Preparation
Synthesis of 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde: Using pyrrole as raw material, after being protected by N-alkylation of triisopropylsilyl chloride, it is then reacted with Vilsmeier reagent to obtain 1H-Pyrrole-3-carbaldehyde, which is then purified by N-bromosuccinimide (NBS) bromination and 2-fluorophenylboronic acid for Suzuki coupling reaction to obtain crude 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde, which was purified with toluene. The total yield was 35.5%.
Definition
The 5-(2-fluorophenyl) -1H-pyrrole-3-formaldehyde is an important intermediate of Voranolan fumarate, a competitive potassium ion acid blocker. Voranolan fumarate treats gastric ulcers, duodenal ulcers, reflux esophagitis, etc. 5-(2-fluorophenyl) -1H-pyrrole-3-formaldehyde can be synthesized in one pot using 2-(2-fluorobenzoyl)malononitrile as raw material.
Hazard
5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde has acute toxin effects and is a skin and eye irritant.
5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Joiny Pharmaceutical Co.,LTD | +8613681955282 | gyd@joiny-pharma.com | China | 255 | 58 |
| AstaTech(Chengdu) Biopharmaceutical Corp. | +86-02882666559 +86-15884417729 | gjpu@astatech.com.cn | China | 308 | 58 |
| Zhuhai Hairuide Bioscience and Technology Co., Ltd | +8618928027945 | sales3@zhhairuide.com | China | 97 | 58 |
| TAIZHOU YUXIN BIOTECHNOLOGY CO,.LTD | +86-576-88902229;+86-0576-88902229 +8613968687450 | yuxin@yuxchem.com | China | 167 | 58 |
| JUYE XIANDAI fine chemistry Co.,Ltd | +86-18958038633; +8618958038633 | tony@sdhypharma.com | China | 64 | 58 |
| Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | sales@hbmojin.com | China | 12839 | 58 |
| Hangzhou ICH Biofarm Co., Ltd | +86-0571-28186870; +undefined8613073685410 | sales@ichemie.com | China | 998 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 | Mandy@hangyubiotech.com | China | 10986 | 58 |
| Shandong Huisheng Import & Export Co., Ltd. | +86-13176845580 +86-13176845580 | da@zhongda-biotech.com | China | 232 | 58 |
| Anhui Zhongda Biotechnology Co., Ltd | +8619956560829 | justine@zhongda-biotech.com | China | 286 | 58 |
View Lastest Price from 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-28 | 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde
881674-56-2
|
US $50.00 / KG | 1KG | 99.9% | 1000 | hebei hongtan Biotechnology Co., Ltd | |
 |
2024-11-27 | 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde
881674-56-2
|
US $0.00 / Kg/Bag | 10g | 99%min | 10kg | WUHAN FORTUNA CHEMICAL CO., LTD | |
 |
2024-11-18 | 5-(2-fluorophenyl)-1H-Pyrrole-3-carboxaldehyde
881674-56-2
|
US $0.00-0.00 / KG | 1KG | 98.0% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd |
-
- 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde
881674-56-2
- US $50.00 / KG
- 99.9%
- hebei hongtan Biotechnology Co., Ltd
-
- 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde
881674-56-2
- US $0.00 / Kg/Bag
- 99%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- 5-(2-fluorophenyl)-1H-Pyrrole-3-carboxaldehyde
881674-56-2
- US $0.00-0.00 / KG
- 98.0%
- Shaanxi Dideu New Materials Co. Ltd
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